DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and klf1

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_571011.1	Gene:	klf1 / 30104	ZFINID:	ZDB-GENE-980526-55	Length:	365	Species:	Danio rerio

Alignment Length:	379	Identity:	109/379 - (28%)
Similarity:	155/379 - (40%)	Gaps:	76/379 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDMDT--LLPSPPATPPLRENKLEIVAKDEQQVN-------ENLLKAKLKLVAQKSQKNGGIITP 56
            :|:|:  |..||.:..|.:      ...||.|.:       |.||.....:..::|  |....||
Zfish    28 LDLDSKDLHQSPASYKPSQ------FLTDEHQDDSEGCWDMEFLLSDWASMSPERS--NSQNYTP 84

  Fly    57 NPSDTEDE-----------AP-----EIAVPNKKPRLEQP--AMSMTPPPDQKLD----DDQKAE 99
            .....:|:           ||     ::.|.:....|..|  .:|.:.|||.:.:    |.|
Zfish    85 QRPTLQDQLHSPDLYQELNAPKPNRHQVCVASSLAELLPPEATLSSSLPPDLQFNCGFLDQQ--- 146

  Fly   100 RVSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMN 164
                        |..|.||.|| ....|....:||.|..:|.           ..:.::..|...
Zfish   147 ------------AAKSYSQAEN-PQQFSAFPVTSNVNRDSSM-----------GKMGKSWDFGHY 187

  Fly   165 RKRAAEVALPP---VQTPETPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTV 226
            .:.|..::.|.   |||....:..:|.||............|.|.....:.|.....|....||
Zfish   188 YQPAPLISFPDSKFVQTQGITMETVVFPPHHHYNFIPSYSHPRLYQQQANYVHRPPPQSHFPST- 251

  Fly   227 AAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGER 291
               ||..|....|....|....|....:..||   ::.|.:|.|.|.|.||||||||.|.||||:
Zfish   252 ---QSMVPDSTVPPAGLESKRIRRGLVKRKAT---VHSCEYPGCQKTYTKSSHLKAHLRTHTGEK 310

  Fly   292 PFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            |:.|.|:.|..:|:|||||:||.|.|||:|.::|.:|.:.|.|||||:.|:|||
Zfish   311 PYHCTWDGCGWKFARSDELTRHFRKHTGQKPYECLLCHRAFSRSDHLALHMKRH 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	14/23 (61%)
		C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	45/76 (59%)
		zf-H2C2_2	279..306	CDD:290200	15/26 (58%)
		C2H2 Zn finger	295..317	CDD:275368	12/21 (57%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
klf1	NP_571011.1	COG5048	287..>344	CDD:227381	34/56 (61%)
		C2H2 Zn finger	287..306	CDD:275368	13/18 (72%)
		zf-H2C2_2	298..>315	CDD:290200	11/16 (69%)
		C2H2 Zn finger	314..336	CDD:275368	12/21 (57%)
		zf-H2C2_2	328..353	CDD:290200	12/24 (50%)
		C2H2 Zn finger	344..364	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910