DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and Klf10

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_036015210.1	Gene:	Klf10 / 21847	MGIID:	1101353	Length:	547	Species:	Mus musculus

Alignment Length:	371	Identity:	126/371 - (33%)
Similarity:	163/371 - (43%)	Gaps:	93/371 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPPATPPLRENKLEIVAK---DEQQVNENLLKAKLKLVAQ------KSQKNGGIITPNPSDTEDE 64
            :|.|.|||.:.:...|.:   |.|..|......|...:..      :.:.:|     |...|...
Mouse   207 NPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHG-----NVEATRKN 266

  Fly    65 APEIAV-PNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSC 128
            .|..|| ||:.          .|.|....|.|:||........|.||..|...||...||.....
Mouse   267 IPCAAVSPNRS----------KPEPSTVSDGDEKAGAALYDFAVPSSETVICRSQPAPSSPVQKS 321

  Fly   129 CSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALP------PVQTPETPVAKLV 187
            ...||.| .||..|||                            ||      |:....:.|:.:|
Mouse   322 VLVSSPT-VSTGGVPP----------------------------LPVICQMVPLPANNSLVSTVV 357

  Fly   188 --TPPA--PAECIKEEEIKPIL---------TPIYVSPVASSASQLILLSTVAAQQSP-----TP 234
              |||:  ||.|      .|:|         |.::|.|      |.::.|......||     :|
Mouse   358 PSTPPSQPPAVC------SPVLFMGTQVPEGTVVFVVP------QPVVQSPRPPVVSPSGTRLSP 410

  Fly   235 VPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWEN 299
            :...|..|..  ..|:| .|..::|.|.:.||.|.|||.||||||||||.|.||||:||.|.|:.
Mouse   411 IAPAPGFSPS--AARVT-PQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKG 472

  Fly   300 CDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            |::||:||||||||:|||||||||.|.:|.::|||||||:||.:||
Mouse   473 CERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	17/23 (74%)
		C2H2 Zn finger	265..287	CDD:275368	17/21 (81%)
		COG5048	<270..362	CDD:227381	55/76 (72%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	14/21 (67%)
		zf-H2C2_2	309..332	CDD:290200	16/22 (73%)
		zf-C2H2	323..345	CDD:278523	12/21 (57%)
		C2H2 Zn finger	325..345	CDD:275368	11/19 (58%)
Klf10	XP_036015210.1	KLF10_N	101..436	CDD:409241	68/287 (24%)
		COG5048	441..>491	CDD:227381	36/49 (73%)
		C2H2 Zn finger	441..460	CDD:275368	15/18 (83%)
		C2H2 Zn finger	468..490	CDD:275368	14/21 (67%)
		zf-C2H2	496..518	CDD:395048	12/21 (57%)
		C2H2 Zn finger	498..518	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11590
eggNOG	1	0.900	-	-		E33208_3BHW9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4250
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012604
OrthoInspector	1	1.000	-	-		otm43603
orthoMCL	1	0.900	-	-		OOG6_110440
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760