DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and EGR4

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001956.4	Gene:	EGR4 / 1961	HGNCID:	3241	Length:	486	Species:	Homo sapiens

Alignment Length:	419	Identity:	106/419 - (25%)
Similarity:	154/419 - (36%)	Gaps:	120/419 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTLLPSPPATPPLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNGGIITPNPSDTEDEAPEI 68
            |.|||.||          ::.:.|       |..|.......::....|.    ||....| |::
Human   135 DALLPGPP----------DLYSPD-------LGAAPFPEAFWEASPCAGA----PSQCLYE-PQL 177

  Fly    69 AVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSS 133
            :.|:.||.|.      .||....||.....:.......:.|.||..:             |.|
Human   178 SPPDVKPGLR------APPASPALDAVSAFKGPYAPWELLSVGAPGN-------------CGS-- 221

  Fly   134 NTNTSTSSVPPTVEDDY---PEANVWRNLKFKMNRKRAAEV--ALPPVQTPETPVAKL------- 186
                         :.||   |||      :|.:...:..::  ...|.:.|..|..:|
Human   222 -------------QGDYQAAPEA------RFPVIGTKIEDLLSISCPAELPAVPANRLYPSGAYD 267

  Fly   187 VTPPAPAECIKEEEIKP-ILTPIYVSP-------------VASSASQL--ILLSTVAAQQSPTPV 235
            ..|.||.:..:..|..| :|||    |             :||:..||  :.|.:.||...|.|:
Human   268 AFPLAPGDLGEGAEGLPGLLTP----PSGEGGSSGDGGEFLASTQPQLSPLGLRSAAAADFPKPL 328

  Fly   236 ----------------PKTPT-MSEEKLTTRITAAQAAATR-------SRIYECSFPDCGKNYFK 276
                            |..|| ..:.|...:.......:||       ::.:.|....|.:::.:
Human   329 VADIPGSSGVAAPPVPPPPPTPFPQAKARRKGRRGGKCSTRCFCPRPHAKAFACPVESCVRSFAR 393

  Fly   277 SSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKH 341
            |..|..|.|:|||.:||.|:  .|.:.|||||.|:.|.|||||||.|.|.||.::|.|||...:|
Human   394 SDELNRHLRIHTGHKPFQCR--ICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRH 456

  Fly   342 VKRHNKDKANGVNRHVSLANNNTSASVAA 370
            .|.|.|.||....|...|...:...|.|:
Human   457 SKVHLKQKARAEERLKGLGFYSLGLSFAS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	6/23 (26%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	42/91 (46%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
EGR4	NP_001956.4	Atrophin-1	<74..339	CDD:331285	55/269 (20%)
		C2H2 Zn finger	382..404	CDD:275368	6/21 (29%)
		COG5048	408..>466	CDD:227381	31/59 (53%)
		C2H2 Zn finger	412..432	CDD:275368	10/21 (48%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940