Protein Alignment cbt and EGR3

DIOPT Version :9

• Sequence 1: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: XP_005273482.1
• Gene: EGR3 / 1960
• HGNCID: 3240
• Length: 442
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 110/443 - (24%)
• Similarity: 155/443 - (34%)
• Gaps: 146/443 - (32%)

  Fly     7 LPSPPATPPLRENKLEIVAKDEQQ--------VNENLLKAKLKLVAQKSQKNGGIITPNPSDTED 63
            ||:||              ::|||        |.||::
Human    87 LPAPP--------------REEQQCFSRARACVCENVM--------------------------- 110

  Fly    64 EAPEIAVPNKKPRLE-QPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSG--AVSSSSQ--DENSS 123
               :|.:.|:||..| ..:.|..|.|..|              .|...|  |..|.|.  .:|..
Human   111 ---DIGLTNEKPNPELSYSGSFQPAPGNK--------------TVTYLGKFAFDSPSNWCQDNII 158

  Fly   124 SSTSC-------CSSSSNTNTSTSSV--PP--TVEDDYPEANVWRN------------------- 158
            |..|.       .|.:.:|.|||:|:  ||  .||..||....:.|
Human   159 SLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPG 223

  Fly   159 LKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIKPI--LTPIYVSPVASSASQLI 221
            |.:.....::|:.||.....|..|...|...|.....|.|.  ||.  :.||.|:|     ..:.
Human   224 LAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEH--KPFQGMDPIRVNP-----PPIT 281

  Fly   222 LLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAATR-------SRIYECSFPDCGKNYFKSSH 279
            .|.|:.|.:.....|...::.:..||.:....:....|       .|.:.|....|.:.:.:|..
Human   282 PLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDE 346

  Fly   280 LKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKR 344
            |..|.|:|||.:||.|:  .|.:.|||||.|:.|.|||||||.|.|..|.:||.|||...:|.|.
Human   347 LTRHLRIHTGHKPFQCR--ICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKI 409

  Fly   345 HNKDKANGVNRHVSLANNNTSASVAASLCDASLHLRAIAPAGSSASSSPISSA 397
            |.|.|.....:                           ..|.|::|:.|:|.|
Human   410 HLKQKEKKAEK---------------------------GGAPSASSAPPVSLA 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	6/23 (26%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	39/91 (43%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
EGR3	XP_005273482.1	DUF3446	142..202	CDD:288757	19/59 (32%)
		COG5048	324..>388	CDD:227381	28/65 (43%)
		zf-C2H2	330..354	CDD:278523	6/23 (26%)
		C2H2 Zn finger	332..354	CDD:275368	6/21 (29%)
		zf-H2C2_2	346..371	CDD:290200	11/26 (42%)
		COG5048	358..>431	CDD:227381	34/101 (34%)
		C2H2 Zn finger	362..382	CDD:275368	10/21 (48%)
		zf-H2C2_2	374..399	CDD:290200	14/24 (58%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940