Protein Alignment cbt and EGR2

DIOPT Version :9

• Sequence 1: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: XP_011537729.1
• Gene: EGR2 / 1959
• HGNCID: 3239
• Length: 489
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 119/494 - (24%)
• Similarity: 179/494 - (36%)
• Gaps: 143/494 - (28%)

  Fly    11 PATPP-LRENKLEIVAKDEQQVNENLLKAKL------KLVAQKSQKNG----GIITPNPSDTEDE 64
            |..|| .|.:.|..|..|.....|:|....:      :|.....|.||    |:|
Human    19 PRDPPERRRSGLAHVLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMI---------- 73

  Fly    65 APEIAVPNKKPRLEQPAMS----MTPPPDQ------KLDDDQKAERVSV----IMRVNSSGAVSS 115
              .|.:..:|..|:.|..|    ::.|.:|      |...|.:....|.    |:.:.|:|.:..
Human    74 --NIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQG 136

  Fly   116 SSQDENSSSSTSCCSSSSN----------TNTSTS-------SVPP-------TVEDDYPEANVW 156
            .:...::::|:|..|:|.|          |.:.|.       |.||       ...|.|.:.:.:
Human   137 VTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAF 201

  Fly   157 RNLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPA------------PAECIKE----------- 198
            .:   ......::.:|.||  .|..|..|..|.|.            |::|.::
Human   202 LS---AATTSTSSSLAYPP--PPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKP 261

  Fly   199 -------EEIKPILTPI--------------YVSPVASSASQ---------LILLSTVAAQQSPT 233
                   ..:.|.|||:              ...|.||..|:         ....:..||..:|.
Human   262 FPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPH 326

  Fly   234 PVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWE 298
            .:|..|.:...|...|   ........|.|.|....|.:.:.:|..|..|.|:|||.:||.|:
Human   327 HLPLRPILRPRKYPNR---PSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCR-- 386

  Fly   299 NCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNKDKANGVNRHVSLANNN 363
            .|.:.|||||.|:.|.|||||||.|.|..|.:||.|||...:|.|.|.:.|..        .::.
Human   387 ICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKER--------KSSA 443

  Fly   364 TSASVAA---SLCDASLHLRAIAPAGSSASSSPISSASL 399
            .||||.|   :.|..     .:.|.|:..||   :|:||
Human   444 PSASVPAPSTASCSG-----GVQPGGTLCSS---NSSSL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	7/23 (30%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	38/91 (42%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
EGR2	XP_011537729.1	DUF3446	107..179	CDD:403215	13/71 (18%)
		zf-C2H2	353..377	CDD:395048	7/23 (30%)
		C2H2 Zn finger	355..377	CDD:275368	6/21 (29%)
		COG5048	381..>449	CDD:227381	33/77 (43%)
		C2H2 Zn finger	385..405	CDD:275368	10/21 (48%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940