Protein Alignment cbt and EGR1

DIOPT Version :9

• Sequence 1: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_001955.1
• Gene: EGR1 / 1958
• HGNCID: 3238
• Length: 543
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 110/412 - (26%)
• Similarity: 172/412 - (41%)
• Gaps: 100/412 - (24%)

  Fly    61 TEDEAPEIAVPNKKPRLEQPAMSMT---------------PPPD--QKLDDDQKAERVSVIMRVN 108
            |.:..|:|::.|:|..:|....|.|               |.|:  ..|..:.....||.::.:.
Human   101 TAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMT 165

  Fly   109 SSGAVSSSSQDENSSSST-------SCCSSSSNTNTSTSSVP--PTVEDD-YPEANVWRNLKFKM 163
            :..|.|||:....:||::       ||...|::::...|:.|  ||...| :||.   ::..|..
Human   166 NPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEP---QSQAFPG 227

  Fly   164 NRKRAAEVALPPVQTPETPVAK---------------------LVTP-PAPAECIKEEEIKPILT 206
            :...|.:  .||   |..|.||                     |.|| ..|.:.::....:|.||
Human   228 SAGTALQ--YPP---PAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLT 287

  Fly   207 PIYVSPVASSASQ-----LILLSTVAAQQ--SPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYE 264
            |:  |.:.:.|:|     |..|:|....|  .|:.:.|.|....:           .....|.|.
Human   288 PL--STIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSK-----------TPPHERPYA 339

  Fly   265 CSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQ 329
            |....|.:.:.:|..|..|.|:|||::||.|:  .|.:.|||||.|:.|.|||||||.|.|.:|.
Human   340 CPVESCDRRFSRSDELTRHIRIHTGQKPFQCR--ICMRNFSRSDHLTTHIRTHTGEKPFACDICG 402

  Fly   330 KKFMRSDHLSKHVKRHNKDKANGVNRHVSLANNNTSA-----SVAASLCDASLHLRAIAPA---- 385
            :||.|||...:|.|.|.:.|....::.| :|::.||:     |..|:...:.:.....:||
Human   403 RKFARSDERKRHTKIHLRQKDKKADKSV-VASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSY 466

  Fly   386 -----------GSSASSSPISS 396
                       |||...||:.|
Human   467 PSPVPTSFSSPGSSTYPSPVHS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	7/23 (30%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	40/91 (44%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		1/3 (33%)
		DUF3446	135..209	CDD:314753	16/73 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..213		13/47 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..284		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..339		4/31 (13%)
		zf-C2H2	338..362	CDD:306579	7/23 (30%)
		C2H2 Zn finger	340..362	CDD:275368	6/21 (29%)
		zf-H2C2_2	354..379	CDD:316026	11/26 (42%)
		C2H2 Zn finger	370..390	CDD:275368	10/21 (48%)
		zf-H2C2_2	382..407	CDD:316026	14/24 (58%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..487		18/78 (23%)
		DUF3432	447..530	CDD:288743	9/42 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940