Protein Alignment cbt and Klf4

DIOPT Version :10

• Sequence 1: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_034767.2
• Gene: Klf4 / 16600
• MGIID: 1342287
• Length: 483
• Species: Mus musculus
• Alignment Length: 480
• Identity: 124/480 - (25%)
• Similarity: 173/480 - (36%)
• Gaps: 149/480 - (31%)

  Fly     4 DTLLPS---PPATPPLRENKLEIVAKDEQQVNENLLKAKLKLVAQKSQKNGGIITPNPSDTEDEA 65
            |.||||   ..:.|..||..|........:..|.|  :.:|.:.....:...:.....:|.|...
Mouse    14 DALLPSFSTFASGPAGREKTLRPAGAPTNRWREEL--SHMKRLPPLPGRPYDLAATVATDLESGG 76

  Fly    66 PEIAVPNKKPRLEQPAMSMTPPPDQKLDDD-----QKAERVSVIMRVNSSGAVSSSSQDENS--S 123
            ...|..:..|.|  .|...|...:..||.|     ....:.||...|.:|.:.||||...:|  :
Mouse    77 AGAACSSNNPAL--LARRETEEFNDLLDLDFILSNSLTHQESVAATVTTSASASSSSSPASSGPA 139

  Fly   124 SSTSCCS-------------SSSNTN-----TSTSSVPPT-------VEDDYPEANVWRNLKFKM 163
            |:.|.||             ::|||.     :..|:.|||       :.|..|.......|.
Mouse   140 SAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTAPFNLADINDVSPSGGFVAELL--- 201

  Fly   164 NRKRAAEVALPPVQTPETP----------VAKLVTPPA--------------------------- 191
             |.....|.:|| |.|:.|          .|.|.||.:
Mouse   202 -RPELDPVYIPP-QQPQPPGGGLMGKFVLKASLTTPGSEYSSPSVISVSKGSPDGSHPVVVAPYS 264

  Fly   192 ---PAEC--IKEEEI------KPILTPIYVSPVASSASQLILLSTVAAQQSPTPVPKTPTMS-EE 244
               |..|  ||:|.:      :.:...:...|..|:..:.........:|.||..  |||:| ||
Mouse   265 GGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSNGHRPNTHDFPLGRQLPTRT--TPTLSPEE 327

  Fly   245 KLTTR--------------------------ITAAQAAA-------------------------- 257
            .|.:|                          ...:|..:
Mouse   328 LLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQMQSQVPSLHYQELMPPGSCLPEEPKPKRGRRSW 392

  Fly   258 --TRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGE 320
              .|:..:.|.:..|||.|.||||||||.|.||||:|:.|.|:.|..:|:|||||:||.|.|||.
Mouse   393 PRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGH 457

  Fly   321 KKFQCSVCQKKFMRSDHLSKHVKRH 345
            :.|||..|.:.|.|||||:.|:|||
Mouse   458 RPFQCQKCDRAFSRSDHLALHMKRH 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	47/76 (62%)
		C2H2 Zn finger	295..317	CDD:275368	12/21 (57%)
		zf-H2C2_2	309..332	CDD:463886	12/22 (55%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
Klf4	NP_034767.2	KLF4_N	7..400	CDD:409228	76/396 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..42		4/19 (21%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:O43474	99..107		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..395		14/102 (14%)
		Interaction with ZNF296. /evidence=ECO:0000269|PubMed:24161396	386..483		49/97 (51%)
		COG5048	<395..478	CDD:227381	45/82 (55%)
		C2H2 Zn finger	402..424	CDD:275368	14/21 (67%)
		C2H2 Zn finger	432..454	CDD:275368	12/21 (57%)
		Interaction with target DNA	443..474		18/30 (60%)
		zf-H2C2_2	446..471	CDD:463886	13/24 (54%)
		C2H2 Zn finger	462..482	CDD:275368	10/19 (53%)