DRSC/TRiP Functional Genomics Resources

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Protein Alignment cbt and Klf3

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_032479.1 Gene:Klf3 / 16599 MGIID:1342773 Length:344 Species:Mus musculus


Alignment Length:265 Identity:81/265 - (30%)
Similarity:113/265 - (42%) Gaps:81/265 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 NLKFKMNRKRAAEVALPPVQTPETPVAKLVTPPAPA--------------------ECIKEEEIK 202
            :|||..:|:.:..:::|    ..:|..|..:||:|.                    ..|:...|.
Mouse    81 SLKFPSHRRASPGLSMP----SSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGIL 141

  Fly   203 PILTPIYVSPV----ASSASQLILLS---TVAAQQSPTPVP-----------------------K 237
            |::.|:.|.||    .|...|.:::|   .:....|..|||                       :
Mouse   142 PVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMDNSNSGMPVPVIESYEKPLLQKKIKIEPGIEPQR 206

  Fly   238 TPTMSEE---KLTTRITAAQA------------------------AATRSRIYECSFPDCGKNYF 275
            |....||   .|...::..||                        ...:.||:.|.:..|.|.|.
Mouse   207 TDYYPEEMSPPLMNPVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYT 271

  Fly   276 KSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSK 340
            ||||||||:|.||||:|:.|.||.|..:|:|||||:||.|.|||.|.|||..|.:.|.|||||:.
Mouse   272 KSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLAL 336

  Fly   341 HVKRH 345
            |.|||
Mouse   337 HRKRH 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 13/23 (57%)
C2H2 Zn finger 265..287 CDD:275368 13/21 (62%)
COG5048 <270..362 CDD:227381 48/76 (63%)
zf-H2C2_2 279..306 CDD:290200 16/26 (62%)
C2H2 Zn finger 295..317 CDD:275368 13/21 (62%)
zf-H2C2_2 309..332 CDD:290200 13/22 (59%)
zf-C2H2 323..345 CDD:278523 12/21 (57%)
C2H2 Zn finger 325..345 CDD:275368 10/19 (53%)
Klf3NP_032479.1 Repressor domain 1..74
9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:P57682 60..68
CTBP-binding motif 61..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..111 9/33 (27%)
COG5048 <169..>331 CDD:227381 52/161 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..254 0/18 (0%)
C2H2 Zn finger 261..283 CDD:275368 13/21 (62%)
C2H2 Zn finger 291..313 CDD:275368 13/21 (62%)
zf-H2C2_2 305..330 CDD:372612 14/24 (58%)
C2H2 Zn finger 321..341 CDD:275368 10/19 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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