Protein Alignment cbt and Klf12

DIOPT Version :10

• Sequence 1: NP_722636.1
• Gene: cbt / 33224
• FlyBaseID: FBgn0043364
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_034766.2
• Gene: Klf12 / 16597
• MGIID: 1333796
• Length: 402
• Species: Mus musculus
• Alignment Length: 387
• Identity: 110/387 - (28%)
• Similarity: 166/387 - (42%)
• Gaps: 93/387 - (24%)

  Fly    36 LKAKLKLVAQKSQKNGGIITPNPSDTED-EAPEIAVPNKK---PRLEQPA---MSMTPPPDQKLD 93
            ::.|.:||  :|::.    :||..:..| ||..:.:.|.|   |....|.   .:.|.|.|..::
Mouse    29 VRVKTELV--ESEQG----SPNVHNYPDMEAVPLLLNNVKGEPPEDSLPVDHFQTQTEPVDLSIN 87

  Fly    94 DDQKAERVSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSSNTNTSTSS----------------- 141
            ..:.:...:....|:.:.:.||.|....||||:|..:||....||.||
Mouse    88 KARTSPTAASSSPVSMTASASSPSSTSTSSSSSSRPASSPTVITSVSSASSSSTVLSPGPLVASA 152

  Fly   142 --------------VPPTVEDDYPEANVWRNLKFKMNR----KRAAEVALPPVQTPETPVAKLVT 188
                          |||:     ...|:..|....::|    .::..|....|::|......:|.
Mouse   153 SGVGGQQFLHIIHPVPPS-----SPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVV 212

  Fly   189 P-------------------PAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQS--P 232
            |                   |..::...:::..|.:|...|:...|:|     ||...|.|.  |
Mouse   213 PLLEDGRSHGKAQMEPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTA-----LSIARAVQEVHP 272

  Fly   233 TPVPKT--PTMSEEKLTTRITAAQAAATR------------SRIYECSFPDCGKNYFKSSHLKAH 283
            :||.:.  ..|:.:|....|:.....:||            .||:.|.|..|.|.|.||||||||
Mouse   273 SPVSRVRGNRMNNQKFACSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAH 337

  Fly   284 QRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            :|.||||:|:.|.||.|..:|:|||||:||.|.|||.|.|:|:.|.:.|.|||||:.|.:||
Mouse   338 RRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRH 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	46/76 (61%)
		C2H2 Zn finger	295..317	CDD:275368	13/21 (62%)
		zf-H2C2_2	309..332	CDD:463886	12/22 (55%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
Klf12	NP_034766.2	KLF12_N	27..224	CDD:410608	42/205 (20%)
		9aaTAD, inactive. /evidence=ECO:0000250|UniProtKB:Q9Y4X4	80..88		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..144		17/62 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..254		3/34 (9%)
		COG5048	<225..401	CDD:227381	68/180 (38%)
		C2H2 Zn finger	319..341	CDD:275368	14/21 (67%)
		C2H2 Zn finger	349..371	CDD:275368	13/21 (62%)
		zf-H2C2_2	363..388	CDD:463886	13/24 (54%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)