DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and KLF8

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001311033.1	Gene:	KLF8 / 11279	HGNCID:	6351	Length:	364	Species:	Homo sapiens

Alignment Length:	397	Identity:	115/397 - (28%)
Similarity:	167/397 - (42%)	Gaps:	94/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DMDTLLPSPPATPPLRENKLEIVAKDE-------QQVNENLLKAKLKLVAQKSQKNG-GIITPNP 58
            |||.|:           |.||:....|       :||..::.......:..:|.... .::..||
Human     8 DMDKLI-----------NNLEVQLNSEGGSMQVFKQVTASVRNRDPPEIEYRSNMTSPTLLDANP 61

  Fly    59 -------SDTEDEAPE--IAVPNKKPRLEQPAMSMTPPPDQKLDDDQKA--ERVSVIMRVNSSGA 112
                   :|.:.|.||  :|.....|::|...:|...|         ||  :..|::........
Human    62 MENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKP---------KAPLQPASMLQAPIRPPK 117

  Fly   113 VSSSSQDENSSSSTSCCSSSSNTNT------------STSS--------VPPTVEDDYPEANVWR 157
            ..||.|....|:|||..|:|:|..|            ||.|        ..|:|
Human   118 PQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGSQQILHVIHTIPSV----------- 171

  Fly   158 NLKFKMNRKRAAEV---ALPPVQT---PETPVAKLVTPPAPAECIKEEEIKPILTPIYVSP--VA 214
            :|..||...:...|   :||.|.|   .:...|.:..|....:......:|  :.|..:||  :.
Human   172 SLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVK--VDPTSMSPLEIP 234

  Fly   215 SSASQLILLSTVAAQQS-----PTPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNY 274
            |.:.:..:.|..:|.||     ..|........||.|..:         |.||::|.|..|.|.|
Human   235 SDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLK---------RRRIHQCDFAGCSKVY 290

  Fly   275 FKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLS 339
            .||||||||:|:||||:|:.|.|:.|..:|:|||||:||.|.|||.|.|:|:.|.:.|.||||||
Human   291 TKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLS 355

  Fly   340 KHVKRHN 346
            .|.:||:
Human   356 LHRRRHD 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	14/23 (61%)
		C2H2 Zn finger	265..287	CDD:275368	14/21 (67%)
		COG5048	<270..362	CDD:227381	46/77 (60%)
		zf-H2C2_2	279..306	CDD:290200	15/26 (58%)
		C2H2 Zn finger	295..317	CDD:275368	12/21 (57%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	11/21 (52%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
KLF8	NP_001311033.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910