DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and KLF2

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_057354.1	Gene:	KLF2 / 10365	HGNCID:	6347	Length:	355	Species:	Homo sapiens

Alignment Length:	160	Identity:	67/160 - (41%)
Similarity:	92/160 - (57%)	Gaps:	21/160 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PPAPAECIKEEEIKPILTPIY-VSPVASSASQLILLSTVAAQQSPTPVPKTPTMSEEKLTTRITA 252
            ||||              |.: :...|::|:..:.|:..||:...|| |.:|.   |.|..:...
Human   213 PPAP--------------PAFGLFDDAAAAAAALGLAPPAARGLLTP-PASPL---ELLEAKPKR 259

  Fly   253 AQAAATRSR--IYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKR 315
            .:.:..|.|  .:.||:..|||.|.||||||||.|.||||:|:.|.|:.|..:|:|||||:||.|
Human   260 GRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYR 324

  Fly   316 THTGEKKFQCSVCQKKFMRSDHLSKHVKRH 345
            .|||.:.|||.:|.:.|.|||||:.|:|||
Human   325 KHTGHRPFQCHLCDRAFSRSDHLALHMKRH 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	47/76 (62%)
		zf-H2C2_2	279..306	CDD:290200	15/26 (58%)
		C2H2 Zn finger	295..317	CDD:275368	12/21 (57%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	12/21 (57%)
		C2H2 Zn finger	325..345	CDD:275368	10/19 (53%)
KLF2	NP_057354.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	43..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..90
		Interaction with WWP1. /evidence=ECO:0000250	111..268		17/72 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..209
		COG5048	<267..350	CDD:227381	46/82 (56%)
		zf-C2H2	272..296	CDD:278523	15/23 (65%)
		C2H2 Zn finger	274..296	CDD:275368	15/21 (71%)
		zf-H2C2_2	288..>310	CDD:290200	13/21 (62%)
		C2H2 Zn finger	304..326	CDD:275368	12/21 (57%)
		zf-H2C2_2	318..343	CDD:290200	13/24 (54%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12138
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910