DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and klf15

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_002938279.1	Gene:	klf15 / 100495857	XenbaseID:	XB-GENE-854149	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	110/422 - (26%)
Similarity:	169/422 - (40%)	Gaps:	126/422 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLPSPPATPPLRENKLEIVAKDEQQV-------------NENLLKAKLKLVAQKSQKNGGII--- 54
            :||||.:......:.....:..:.||             .:|:|.   .|::|.|..|..:.
Frog    33 MLPSPTSEDDSDSSSFRSCSSPDSQVLSSSYGSACSAESQDNILD---YLLSQTSLGNASLSWWD 94

  Fly    55 --TPNPSDTED--EAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAE---------------- 99
              ...|...|:  :.||..|..::.....|.:...   ::.|:::.|.:
Frog    95 KRRQQPVVKEEFLKVPEFGVDMEETTFFHPTLDEI---EEFLEENMKTDFKDEDRHDAKELRTCG 156

  Fly   100 -------RVSVIMRVNSSG-AVSSSSQDENSSSSTSC----------------CSSSSNTNTSTS 140
                   .|:..|:.:.:| .:.|..:|||:..|.:.                ....||||.|:
Frog   157 QLFSDPHAVNSSMKEDINGETILSVPEDENTKGSDAVSVEGGIPVILQIQPIEIKQESNTNQSS- 220

  Fly   141 SVPPTVEDDYPEANVWRNLK---FKMNRKRAAEVALPPVQTPETPVAKLVTPPAPAECIKEEEIK 202
                    .:||     |:|   ..:|.:......:|.:.......:|.|            .|.
Frog   221 --------QFPE-----NIKVAQLLVNIQGQTFALVPQLVQSSNLSSKFV------------RIA 260

  Fly   203 PILTPIYVSPVASSA---SQLILLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYE 264
            |:  ||...||....   .|..::.....|::|                       |....::::
Frog   261 PV--PIAAKPVGPGGGIQGQAGVMIGQKFQKNP-----------------------ATELIKMHK 300

  Fly   265 CSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQ 329
            |:||.|.|.|.||||||||.|.||||:||.|.|..|..|||||||||||:|:|:|.|.:||:||:
Frog   301 CTFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCAVCE 365

  Fly   330 KKFMRSDHLSKHVKRHNKDKANGVNRHVSLAN 361
            |||.||||||||:|.|...::   :|...|:|
Frog   366 KKFARSDHLSKHIKVHRFPRS---SRSTRLSN 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	56/92 (61%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	15/21 (71%)
		zf-H2C2_2	309..332	CDD:290200	14/22 (64%)
		zf-C2H2	323..345	CDD:278523	16/21 (76%)
		C2H2 Zn finger	325..345	CDD:275368	15/19 (79%)
klf15	XP_002938279.1	SFP1	<284..379	CDD:227516	57/117 (49%)
		C2H2 Zn finger	301..323	CDD:275368	15/21 (71%)
		C2H2 Zn finger	331..353	CDD:275368	15/21 (71%)
		zf-H2C2_2	345..370	CDD:372612	16/24 (67%)
		C2H2 Zn finger	361..381	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12009
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940