DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and egr3

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_002932749.1	Gene:	egr3 / 100488713	XenbaseID:	XB-GENE-976448	Length:	380	Species:	Xenopus tropicalis

Alignment Length:	312	Identity:	84/312 - (26%)
Similarity:	119/312 - (38%)	Gaps:	85/312 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NGGIITPNPSDTEDEAPEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVS 114
            |||::..|.:|.|.....:                   |......|...|:|.    ....|...
Frog   126 NGGLMGQNQNDVESMFHGL-------------------PSYAGCGDLYHEQVG----FQGGGMAP 167

  Fly   115 SSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPV-QT 178
            .:|||.:|:.           .:..|.|.|.:    |:.|::.:           ...:||| |.
Frog   168 YTSQDYSSAK-----------QSLDSGVFPMI----PDYNLFHH-----------NTEMPPVDQK 206

  Fly   179 P-ETPVAKLVTPP--APAECI---KEEEIKPILTPIYVSPVASSASQLILLSTVAAQQSPTPVPK 237
            | :...|..|.||  .|.|.|   ||:::.|....:...|.       :.|..:..::.|....|
Frog   207 PFQNMEAIRVNPPPITPLETIKAFKEKQVLPSFGGMGHQPP-------LTLKPIRPRKYPNRPSK 264

  Fly   238 TPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDK 302
            ||                  ...|.:.|....|.:.:.:|..|..|.|:|||.:||.|:  .|.:
Frog   265 TP------------------LHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCR--ICMR 309

  Fly   303 RFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRH--NKDKANG 352
            .|||||.|:.|.|||||||.|.|..|.:||.|||...:|.|.|  .|||..|
Frog   310 SFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHAKIHLKQKDKKGG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	6/23 (26%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	41/85 (48%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
egr3	XP_002932749.1	SFP1	<238..350	CDD:227516	43/138 (31%)
		C2H2 Zn finger	274..296	CDD:275368	6/21 (29%)
		COG5048	300..>352	CDD:227381	28/53 (53%)
		C2H2 Zn finger	304..324	CDD:275368	10/21 (48%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940