DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cbt and egr2

DIOPT Version :9

Sequence 1:NP_722636.1 Gene:cbt / 33224 FlyBaseID:FBgn0043364 Length:428 Species:Drosophila melanogaster
Sequence 2:NP_001093725.1 Gene:egr2 / 100101746 XenbaseID:XB-GENE-853290 Length:429 Species:Xenopus tropicalis


Alignment Length:403 Identity:107/403 - (26%)
Similarity:158/403 - (39%) Gaps:78/403 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 GGIITPNPSDTEDEAPEIAVPNKKPRLEQPAMSMTP--PPDQKLD-------DDQ------KAER 100
            ||......|.|.|....:.:.|:|..|:....|..|  |..|.|.       |.|      ..|.
 Frog    45 GGPFDQMNSVTGDGMISVDMNNEKRSLDFSYSSNYPSAPRSQPLAYMGKFSFDPQYPGAGWNTEG 109

  Fly   101 VSVIMRVNSSGAVSSSSQDENSSSSTSCCSSSSNTNTSTSSVPPTVEDD-------YPEAN-VWR 157
            :..|:...|...|..||    |||:||..:||.:.|.|.|...|..:.|       |...| :::
 Frog   110 IFNIVSAASILGVPPSS----SSSTTSSNASSGSPNLSCSMAHPQSDMDHIYSPPPYSSCNEIYQ 170

  Fly   158 NLKFKMNRKRAAEVALPPVQTPETPVAKLVTP--------------------------PAPAECI 196
            :....:.....|....|...:|:......|.|                          |.|.:.|
 Frog   171 DPSAFIGTSTGAPYPPPSYPSPKGASDGSVFPMIPDYSALFPPQCQRDLHSMPDRKPFPCPLDSI 235

  Fly   197 KEEEIKPILTPIYV---SPVASSASQLILLSTVAAQQSPTPVPKTPTMSEEKLTTRITAAQAAAT 258
            :   :.|.|||:..   ..:..|:::   .|.:.:..||..:|..|.:...|...|   ......
 Frog   236 R---VPPPLTPLSTIRNFTLGGSSNE---GSRLPSAYSPHNLPLRPILRPRKYPNR---PSKTPV 291

  Fly   259 RSRIYECSFPDCGKNYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKF 323
            ..|.|.|....|.:.:.:|..|..|.|:|||.:||.|:  .|.:.|||||.|:.|.|||||||.|
 Frog   292 HERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCR--ICMRNFSRSDHLTTHIRTHTGEKPF 354

  Fly   324 QCSVCQKKFMRSDHLSKHVKRHNKDKANGVNRHVSLANNNTSASVAASLCDASLHLRAIAPAGSS 388
            .|..|.:||.|||...:|.|.|.:.|..        .|:.|:|...::..:..|   :::|||:.
 Frog   355 ACDYCGRKFARSDERKRHTKIHLRQKER--------KNSATAAPSGSATQERPL---SLSPAGTG 408

  Fly   389 ASSSPISSASLQV 401
            .|.....|:|.|:
 Frog   409 NSMCSTGSSSGQL 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbtNP_722636.1 zf-C2H2 263..287 CDD:278523 7/23 (30%)
C2H2 Zn finger 265..287 CDD:275368 6/21 (29%)
COG5048 <270..362 CDD:227381 38/91 (42%)
zf-H2C2_2 279..306 CDD:290200 11/26 (42%)
C2H2 Zn finger 295..317 CDD:275368 10/21 (48%)
zf-H2C2_2 309..332 CDD:290200 12/22 (55%)
zf-C2H2 323..345 CDD:278523 10/21 (48%)
C2H2 Zn finger 325..345 CDD:275368 9/19 (47%)
egr2NP_001093725.1 DUF3446 92..161 CDD:371803 20/72 (28%)
zf-C2H2 296..320 CDD:333835 7/23 (30%)
C2H2 Zn finger 298..320 CDD:275368 6/21 (29%)
COG5048 324..>391 CDD:227381 33/76 (43%)
C2H2 Zn finger 328..348 CDD:275368 10/21 (48%)
C2H2 Zn finger 356..376 CDD:275368 9/19 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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