DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbt and egr1

DIOPT Version :9

Sequence 1:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001090830.1	Gene:	egr1 / 100038164	XenbaseID:	XB-GENE-853412	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	386	Identity:	112/386 - (29%)
Similarity:	163/386 - (42%)	Gaps:	95/386 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EIAVPNKKPRLEQPAM------SMTPPPDQK--LDDDQKAERVSVIM---RVNSSGAVSSSSQDE 120
            |.:..|:..||  |::      |:.|.|:..  |..:.....||.::   ..:.|.|.|||....
Frog    89 ESSYANQSARL--PSLTYTGRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANASPSSAPSSSPSSS 151

  Fly   121 NSSSSTS---CCSSSSNTNTSTSSVPPTVEDDYPEANVWRNLKFKMNRKRAAEVALPPVQTPE-- 180
            :||||.|   .||..||.::...|..||..:..||                    |.|.|:|:
Frog   152 SSSSSQSPPLSCSVQSNDSSPIYSAAPTFPNSSPE--------------------LFPDQSPQPF 196

  Fly   181 --TPVAKLVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILLSTVAAQQSPTPVPKTPTMSE 243
              ...|.:..|| ||..:.:...:..:.|.|:.|     .|...:|.|:|.|.|....::.|  :
Frog   197 QNASTASIPYPP-PAYPVSKTTFQVPMIPDYLFP-----QQQGDVSLVSADQKPFQAMESRT--Q 253

  Fly   244 EKLTTRITAAQAAATRS-----------------------------------RIYECSFPDCGKN 273
            :...|.::..:|.||::                                   |.|.|....|.:.
Frog   254 QPSLTPLSTIKAFATQTSQDLKTINSTYQSQIIKPSRMRKYPNRPSKTPPHERPYACPVESCDRR 318

  Fly   274 YFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHL 338
            :.:|..|..|.|:|||::||.|:  .|.:.|||||.|:.|.|||||||.|.|.:|.:||.|||..
Frog   319 FSRSDELTRHIRIHTGQKPFQCR--ICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDER 381

  Fly   339 SKHVKRH--NKDKANGVNRHVSLANNNTSASVAASLCDASLHLRAIAPAGSSASSSPISSA 397
            .:|.|.|  .|||.......||:|:..:|.|.:||....|       |..:| .|||:|||
Frog   382 KRHTKIHLRQKDKKADKATPVSVASPVSSYSPSASTSYPS-------PVPTS-YSSPVSSA 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	7/23 (30%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	43/93 (46%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
egr1	NP_001090830.1	DUF3446	106..180	CDD:288757	22/73 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..309		1/20 (5%)
		zf-C2H2	308..332	CDD:278523	7/23 (30%)
		C2H2 Zn finger	310..332	CDD:275368	6/21 (29%)
		zf-H2C2_2	324..349	CDD:290200	11/26 (42%)
		C2H2 Zn finger	340..360	CDD:275368	10/21 (48%)
		zf-H2C2_2	352..377	CDD:290200	14/24 (58%)
		C2H2 Zn finger	368..388	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..423		15/50 (30%)
		DUF3432	401..486	CDD:288743	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940