Protein Alignment MED15 and med15

DIOPT Version :9

• Sequence 1: NP_608528.1
• Gene: MED15 / 33223
• FlyBaseID: FBgn0027592
• Length: 749
• Species: Drosophila melanogaster
• Sequence 2: NP_998238.2
• Gene: med15 / 406346
• ZFINID: ZDB-GENE-040426-2032
• Length: 802
• Species: Danio rerio
• Alignment Length: 887
• Identity: 262/887 - (29%)
• Similarity: 376/887 - (42%)
• Gaps: 255/887 - (28%)

  Fly     4 DWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKS 68
            ||:|..|||.|:::|.:.:.......||::..||:|:|.|::|::|||.:||:|.:|::|:.:|:
Zfish     9 DWRSPAFRQKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKA 73

  Fly    69 QQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQ-----GNRNP--QMMPM--------- 117
                     ||||              ||:||||||...     |.|.|  ||..|
Zfish    74 ---------QGGP--------------DPINALQNLPGGVPGVIGPRPPGAQMGGMGQMSMGPHA 115

  Fly   118 --GAGGGAPVPGGPGTASNLLQSLNQQRPGQQ-----------QMQPMSNIRGQMPMGAGGAGAQ 169
              |..||....|..|....::|...||:..||           |.|..:.::.|.|     :...
Zfish   116 MQGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQTFQPQQQQQATMQSQQP-----SAMF 175

  Fly   170 QMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAG 234
            |.:::||:||              ..|||.....|..||.
Zfish   176 QQIRLQQLQQ--------------HHQNQQMQHQNQQQQQ------------------------- 201

  Fly   235 GPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQ-----------------LGMGMNPMM 282
                       ..||.|...::...|||...:||:||.|                 .........
Zfish   202 -----------AQNQQQQNQLHQTRMQQQLQLQQLQQQQQQQQQLHQQQVHAQAQAQAQAQAQAQ 255

  Fly   283 RMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMG--VN 345
            ...|.......|.......|...|.....:.....|||:        .||..|...:.|.|  |.
Zfish   256 AQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQL--------QVQAQGQPQVQGQGGAVQ 312

  Fly   346 MPPNLQQK----PNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQ 406
            |||:.||:    |.|..||..||...:: ...:..||..|..|:........||.|||.|.||.|
Zfish   313 MPPHSQQQQVLVPQMVQGQHSQMSALSQ-QQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQ 376

  Fly   407 QQQQQ----------------------------------------------------LVVGN--- 416
            |||||                                                    :.:|.
Zfish   377 QQQQQQQQQQHQQQQVQQVQQASQLTAVPGQMMPRPGMQIPPRLPRATPNSAIPQNPVAIGGQQM 441

  Fly   417 ---------------QTPTQQP------PTPQMPT--PNMI-----PSP-ALVPQSSPQMMQMQN 452
                           |||...|      |:||.|:  ||.:     ||| ...|..|||..|...
Zfish   442 PQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSQSPA 506

  Fly   453 SQRNIRQQSPSASINTPGQVTGNSPFNP-----------QEEALYREKYKQLTKYIEPLKRMLAK 506
            |.|.  .||....:.:||.:  |:|.||           .|:.||.:|.:||:||||||:||:.|
Zfish   507 SSRT--PQSYPLQVPSPGPL--NTPGNPSSVMSPAGASQSEDQLYMDKLRQLSKYIEPLRRMINK 567

  Fly   507 ISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKM--DL---------ISYSGQQFG 560
            |..:....:.::||..||.||.:|..|.||:||.|||.||||:  |:         :..:.:|:
Zfish   568 IDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPCTKKQY- 631

  Fly   561 KSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAP-VPAKRPRVEEKSTSFEQEVPHV 624
             ...|:|:.:...::|||.||:|||||.|.:..:.|..||.| :|:::.::|:..   .|.:|::
Zfish   632 -LCQPILDAVLANIRSPVFNHSLYRTFAPAMTAIHGPQITGPSIPSRKRKLEDDE---RQTIPNI 692

  Fly   625 LQGEIARLDTKFKVKLDTTSQINNKAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQE 689
            ||||:|||::||.|.||.:...||..:.|||.||||.||||||:.:|:|.:||.|:|......|:
Zfish   693 LQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQ 757

  Fly   690 YSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQAC 731
            |.|.||||||.:.:.:::.:||..:|::.||:||..:|||||
Zfish   758 YEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQAC 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED15	NP_608528.1	Med15	12..749	CDD:255446	257/879 (29%)
med15	NP_998238.2	Med15	17..799	CDD:255446	255/877 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..137		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..210		12/77 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..542		29/139 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575187
Domainoid	1	1.000	250	1.000	Domainoid score	I2084
eggNOG	1	0.900	-	-		E1_KOG4274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2980
OMA	1	1.010	-	-		QHG47455
OrthoDB	1	1.010	-	-		D1424577at2759
OrthoFinder	1	1.000	-	-		FOG0007378
OrthoInspector	1	1.000	-	-		oto39573
orthoMCL	1	0.900	-	-		OOG6_108720
Panther	1	1.100	-	-	LDO	PTHR31804
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770