DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED15 and Med15

DIOPT Version :9

Sequence 1:	NP_608528.1	Gene:	MED15 / 33223	FlyBaseID:	FBgn0027592	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	NP_001101795.1	Gene:	Med15 / 360743	RGDID:	1307560	Length:	790	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	263/856 - (30%)
Similarity:	372/856 - (43%)	Gaps:	206/856 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKS 68
            ||:|..|||.::|:|.|.:.......:|::..||:|:|.|::|:||||.|||:|.:|::|:..|.
  Rat     9 DWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKK 73

  Fly    69 QQ------QQQQQQQQGGPPPNA------EMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGG 121
            .|      ....|...|||.|.|      ..|.||:     |..:..|.:.|    |.:|:   .
  Rat    74 SQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQS-----LGGMGGLGAMG----QPLPL---S 126

  Fly   122 GAPVPGGPGTASNLLQSLNQQRP-----------GQQQMQPMSNIRGQMPMGAGGAGAQQMMQVQ 175
            |.|.||..|.|.:.:..::...|           .|||.|.....:.|.      |..||..|.|
  Rat   127 GQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQFQQQQ------AALQQQQQQQ 185

  Fly   176 QMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGPNAAP 240
            |.||               .|.|.|...|..||....|....|:
  Rat   186 QQQQ---------------QQQQFQAQQNAMQQQFQAVVQQQQL--------------------- 214

  Fly   241 GAGGPGPNQMQGGPMNV------NAMQQMPPMQQI--------------QQNQLGMGMNPMMRMG 285
                    |.|....::      :..|||...||:              ||.|..:...|.|
  Rat   215 --------QQQQQQQHLIKLHHQSQQQQMQQQQQLQRMAQLQLQQQQQQQQQQQALQAQPPM--- 268

  Fly   286 QGNGMGGPQGMPGQGM-------------QGMPQGPHNVVG-------GPAGQQQ--------VG 322
            |...|..||..|.|.:             |..||...:.|.       .|..|.|        :.
  Rat   269 QQPPMQQPQPPPSQALPQQLSQMHHPQHHQPPPQAQQSPVAQNQPPQLQPQSQNQPLVSQAQALS 333

  Fly   323 GAGL-----------PPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMF-PG-------- 367
            |..|           ||..|||..:.|   ....:.|.:|.:..:...|:.||. ||
  Rat   334 GPMLYAAQQPLKFVRPPMVVQQPQVQP---QVQQVQPQVQPQAAVQTAQSAQMVAPGVQMIAEAL 395

  Fly   368 NRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQ-------QQQQQLVVGNQTPTQQPPT 425
            .:||:.|..:.|....|.:.||.:.:...|..||:.|..       ...||:    |||...||.
  Rat   396 AQGGMHVRARFPPTSTMSAGPSSSISLGGQPTAQVSQSSLTMLSSPSPGQQV----QTPQSMPPP 456

  Fly   426 PQ-------MPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSP-SASINTPGQVTGNSPFNPQ- 481
            ||       .|..|:...||..|.|.......|.||..:..::| :.|:.:||.:  |:|.||.
  Rat   457 PQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPL--NTPVNPSS 519

  Fly   482 ----------EEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPL 536
                      ||..|.:|.|||:||||||:||:.||..:....:.::||..||:||.:|::|.||
  Rat   520 VMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPL 584

  Fly   537 ETLLKCEKALEKM--DL---------ISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPT 590
            :||.|||.||||:  |:         :..:.||  ....|||:.:...::|||.||:|||||.|.
  Rat   585 KTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQ--DLCQPLLDAVLANIRSPVFNHSLYRTFVPA 647

  Fly   591 LELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKAIRLIC 655
            :..:.|..|.:||...|.|..|:..  .|.:|:|||||:||||.||.|.||.:...||..:.|||
  Rat   648 MMAIHGPPIVSPVVCSRKRRFEEDE--RQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLIC 710

  Fly   656 CLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLL 720
            .||||.||||||:.:|||.:||.|:|.....:.:|.|.||||:|.:.:.:|:.:||..:|::.||
  Rat   711 KLDDKDLPSVPPLELSVPADYPAQSPMWVDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALL 775

  Fly   721 DTWEMAVRQAC 731
            :||..::.|||
  Rat   776 NTWAQSIHQAC 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED15	NP_608528.1	Med15	12..749	CDD:255446	258/848 (30%)
Med15	NP_001101795.1	Med15	17..786	CDD:312941	256/846 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335993
Domainoid	1	1.000	246	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG4274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2852
OMA	1	1.010	-	-		QHG47455
OrthoDB	1	1.010	-	-		D1424577at2759
OrthoFinder	1	1.000	-	-		FOG0007378
OrthoInspector	1	1.000	-	-		oto98177
orthoMCL	1	0.900	-	-		OOG6_108720
Panther	1	1.100	-	-	LDO	PTHR31804
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770