Protein Alignment MED15 and mdt-15

DIOPT Version :10

• Sequence 1: NP_608528.1
• Gene: MED15 / 33223
• FlyBaseID: FBgn0027592
• Length: 749
• Species: Drosophila melanogaster
• Sequence 2: NP_001380037.1
• Gene: mdt-15 / 175817
• WormBaseID: WBGene00007016
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 911
• Identity: 202/911 - (22%)
• Similarity: 293/911 - (32%)
• Gaps: 344/911 - (37%)

  Fly     3 EDWQSQKFRQNVISKIHDLLPPNAQDQTK-----NAGVMENHIFRKSRTKDEYLGLVAKLFMHYK 62
            |||.|.|||::||.::...|..|.|:...     :|..:|.::|.|..:||||:..:||:.....
 Worm     4 EDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAIN 68

  Fly    63 DMSRKSQQQQQQQQQQGGPPP--------NAEMGGGQN----MMQDPLNALQNLASQGNRNPQM- 114
            ..|:.:......|..|...||        |...||...    :..||    |..::|. |||.:
 Worm    69 CNSKSAAVPSVLQPSQFHSPPCTTAALLGNTPAGGTPGYRAPVPPDP----QPTSAQA-RNPPVT 128

  Fly   115 --------MPMGAG--GGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMSNIR--GQMPMGAGGAG 167
                    .|....  ||.|.|....||:  :.:.....|     .|.::||  ||:..|:...|
 Worm   129 VATTQASTTPSAPNPPGGLPAPSASATAA--VAAAVASFP-----SPDTSIRPGGQITPGSQAPG 186

  Fly   168 AQQMMQVQQMQQGGNAPGVMNVMGAGGGQ-NQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVG 231
                        ||..|........|..| |.|..:|.|..|||.    || |.|| ||   ..|
 Worm   187 ------------GGPTPAPNVPFPNGSSQMNGGPAMGQPPPQMGA----PN-MGGP-PN---GYG 230

  Fly   232 GAGGPNAAPGAGGPGPNQMQGGPMNVNAMQQM------PPMQQIQQNQLGMGMNPMMRMGQGNGM 290
            |.|..|..||:|.|    |.|.|.|....:.|      .|...:.|.|...|..|..:
 Worm   231 GYGMMNGPPGSGAP----MGGNPYNQQIKKDMDQARPWDPSAHMYQQQPQWGAMPPQQ------- 284

  Fly   291 GGPQGMPGQGMQGM---PQGP-----------------HNVVGGPAG------------------ 317
              |.|.||:.|.|.   |.||                 ||.:|.|..
 Worm   285 --PHGYPGRPMNGQGATPTGPSSVLESLINQPQQYPGHHNQMGPPGDRNVAAQRAAAQQQQQQQQ 347

  Fly   318 QQQVGGAGLPPNAVQQGGM-------------NPMGGMG-------------------------- 343
            |||....|:.||   ||.|             |..|...
 Worm   348 QQQQQRPGMVPN---QGMMSSEDQTVYSAKLRNMRGSCDSLRTRARQCRHEGNHEAAHKLEVMLS 409

  Fly   344 --------------------------VNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVG------G 376
                                      :|:.|..|.:.:  ||....|..|....:|.|      |
 Worm   410 VLEGKRVVSLEYLNHLEMWIARKQDFLNIAPMSQNQNH--MGMNDPMMNGEHAMLGNGQVPNPYG 472

  Fly   377 QQPG---QPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMI---- 434
            ..||   |.:|  .|.|...|..|.....||..||||::               ||..:|:
 Worm   473 GHPGYGHQQYM--GPPPPHMQMHQPPMWHQQQHQQQQRM---------------MPQDHMMMQGG 520

  Fly   435 --PSPALV-------PQSSPQMMQMQNSQRNIRQQSPSASINT------PGQV-------TGNSP 477
              |...:.       |.:||     .|:.|:....:|:|..|.      ||.:       :|:|.
 Worm   521 GGPVHGMYRGDMGHDPMTSP-----VNNHRHAPYPNPAAMRNNMRMPNGPGPIGRDRNSMSGSSM 580

  Fly   478 FNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEI-----LCNPTQRVPLE 537
            ..|...|          ..:.|:.....|:...|:    |..||.|.::     |.|||   |::
 Worm   581 SGPSSGA----------PSMNPMGTPNQKMGTPGS----MGGMSGLDDLNYDDFLPNPT---PID 628

  Fly   538 TLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQS--PVANHTLYRTFRPTLELLFGTDIT 600
            .|                        .|.|.|...::.:  ||....|..|.|..|::
 Worm   629 AL------------------------QPTLHVGQNSMNAGPPVQRSNLNETARKELQI------- 662

  Fly   601 APVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINN-KAIRLICCLDDKRLPS 664
                                           ||.:|::  |...|.:: ..|.::|.:.:::.
 Worm   663 -------------------------------LDARFEI--DPNHQRHDANHIIVVCKIRNQQF-- 692

  Fly   665 VPPVSVSVPEEYPWQAPDCSLAEQEYSATPFL-QTVQQALIARISKLPKNYSLSHLLDTWEMAVR 728
             ||:.:.||..||  |.:.::.........:| ..:|.::..|:|: |...|::..|:.||..|.
 Worm   693 -PPLRLVVPTTYP--AGNVTVDRAVIDLDAYLYDDLQNSVYERLSR-PGLSSITDYLNAWEEQVN 753

  Fly   729 Q 729
            |
 Worm   754 Q 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED15	NP_608528.1	Med15	12..749	CDD:312941	195/902 (22%)
mdt-15	NP_001380037.1	Med15	13..780	CDD:312941	195/902 (22%)