DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crq and SCARB1

DIOPT Version :9

Sequence 1:	NP_001245823.1	Gene:	crq / 33219	FlyBaseID:	FBgn0015924	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001354910.1	Gene:	SCARB1 / 949	HGNCID:	1664	Length:	552	Species:	Homo sapiens

Alignment Length:	477	Identity:	141/477 - (29%)
Similarity:	235/477 - (49%)	Gaps:	31/477 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CGETQRKVWVFG-LGSVFLL---LGILIVVFWPGIADNLVEDGLTLKPGTDAYESWLEAPIPIYL 66
            |....|  |..| ||...||   ||.:::|..|.:....|...:.:.|.:.::..|.|.|||.||
Human     3 CSAKAR--WAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYL 65

  Fly    67 SFYMFNWTNPEDIRNPDIKPNFVEMGPYTFLEKHKKENYTFYDNATVAYYERRTWFFDPERSNGT 131
            |.|.|:..||.:|...: ||...|.|||.:.|...|.|.||.:|.||::.|.||:.|.|.:|:|:
Human    66 SVYFFDVMNPSEILKGE-KPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGS 129

  Fly   132 LDDMVTAAHAITATVADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEGYQDNITDFLNL 196
            ..|.:...:.:....|..|.::...:|.|:.......|.:.::.:.||| |..||:|.:.:.:|.
Human   130 ESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGE-IMWGYKDPLVNLINK 193

  Fly   197 FNTTKIDIPYK-RFGWLADRNESLTYDGLFTIHTGTDDISNLGRLTHWNGKSETGFYEM-PCGIV 259
            :....  .|:| :||..|:.|.|  ..||||:.||..:||.:..:..|||.|:..|:.. .|.::
Human   194 YFPGM--FPFKDKFGLFAELNNS--DSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMI 254

  Fly   260 NGTTGDMFPPKMNVNDEITIFATDACRFMNL--RPRGTYENHGLTATKWVGTEETLDSGENYPNQ 322
            |||:|.|:||.|.....:..::.:|||.|.|  :..|.:|  |:...::|..:....:|..||..
Human   255 NGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFE--GIPTYRFVAPKTLFANGSIYPPN 317

  Fly   323 ACFCDEARFDECPKTGVVECKACRDKAPIYSSFPHFYLADQSYVDAVSGMKPEKEKHEFFLAVEP 387
            ..||      .|.::|:.....||..||::.|.|||..||....:||:|:.|.:|.|..||.:.|
Human   318 EGFC------PCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHP 376

  Fly   388 ITGVPVQVHGRIQINMMIEPDDDFDIYRGVQKVLMPMFWFDQYAELSSE----LASKAKLAINLS 448
            :||:|:....::|:::.::..........::.|::|:.||.:...:..|    ..::..|...:.
Human   377 VTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVM 441

  Fly   449 SYGIIFGYSMIAFASVFLITGI 470
            .|.   .|.::|...|.|:..:
Human   442 HYA---QYVLLALGCVLLLVPV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crq	NP_001245823.1	CD36	19..470	CDD:307331	136/461 (30%)
SCARB1	NP_001354910.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148206
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21132
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860