DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crq and CD36

DIOPT Version :9

Sequence 1:	NP_001245823.1	Gene:	crq / 33219	FlyBaseID:	FBgn0015924	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	493	Identity:	119/493 - (24%)
Similarity:	234/493 - (47%)	Gaps:	58/493 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CCKCCGETQRKVWVFGLGSVFLLLGILIVVFWPGIADNLVEDGLTLKPGTDAYESWLEAPIPIYL 66
            |.:.||.....|    :|:|..:.|.:::.....:....::..:.|:.||.|:::|::....:|.
Human     3 CDRNCGLIAGAV----IGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYR 63

  Fly    67 SFYMFNWTNPEDIRNPDIKPNFVEMGPYTFLEKH-KKENYT--FYDNATVAYYERRTWFFDPERS 128
            .|::|:..||:::..........:.||||:..:. .|||.|  ..|| ||::.:.....|:|..|
Human    64 QFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDN-TVSFLQPNGAIFEPSLS 127

  Fly   129 NGTLDDMVTAAHAITATVADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEGYQDNITDF 193
            .||..|..|..:...|..:...::|  .|:.|:|.::|.....::..:.:.|.:: ||:|   .|
Human   128 VGTEADNFTVLNLAVAAASHIYQNQ--FVQMILNSLINKSKSSMFQVRTLRELLW-GYRD---PF 186

  Fly   194 LNLFN---TTKIDI--PYKRFGWLADRNESLTYDGLFTIHTGTDDISNLGRLTHWNGKSETGFYE 253
            |:|..   ||.:.:  ||..           |.||::.:..|.|:||.:..:..:.||....::|
Human   187 LSLVPYPVTTTVGLFYPYNN-----------TADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWE 240

  Fly   254 MPCGIVNGTTGDMFPPKMNVNDEITIFATDACRF--------MNLRPRGTYENHGLTATKWVGTE 310
            ..|.::|||....|||.:..:..:..|::|.||.        :||:        |:...::|...
Human   241 SHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLK--------GIPVYRFVLPS 297

  Fly   311 ETLDSGENYPNQACFCDEARFDE-CPKTGVVECKACRDKAPIYSSFPHFYLADQSYVDAVSGMKP 374
            :...|....|:..|||.|....: |...||::...|::..|:|.|.|||..|.....:.:.|:.|
Human   298 KAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNP 362

  Fly   375 EKEKHEFFLAVEPITGVPVQVHGRIQINMMIEPDDDFDIYRGVQK-VLMPMFWFDQYAELSSELA 438
            .:|:|..:|.:|||||..:|...|:|:|::::|.:...:.:.::: .::|:.|.::...:..|.|
Human   363 NEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKA 427

  Fly   439 S--KAKLAINLSSYGIIFGYSMIAFASVFLITGITLTV 474
            :  ::::...::..|:|        ..:.|..|:.:.|
Human   428 NMFRSQVTGKINLLGLI--------EMILLSVGVVMFV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crq	NP_001245823.1	CD36	19..470	CDD:307331	113/470 (24%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	116/482 (24%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		8/27 (30%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820