DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crq and Cd36

DIOPT Version :9

Sequence 1:	NP_001245823.1	Gene:	crq / 33219	FlyBaseID:	FBgn0015924	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	123/501 - (24%)
Similarity:	235/501 - (46%)	Gaps:	75/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CCKCCGETQRKVWVFGLGSVFLLLGILIVVFWPGIADNLVEDGLTLKPGTDAYESWLEAPIPIYL 66
            |.:.||.....|    :|:|..:.|.:::.....:.:..::..:.|:.||.|:::|::....:|.
  Rat     3 CDRNCGLITGAV----IGAVLAVFGGILMPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYR 63

  Fly    67 SFYMFNWTNPEDIRNPDIKPNFVEMGPYTFLEKH-KKENYTFYD--NATVAYYERRTWFFDPERS 128
            .|::|:..|||::.....|....:.||||:..:: .|||.| .|  ::||::.:.....|:|..|
  Rat    64 QFWIFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKENIT-QDPKDSTVSFVQPNGAIFEPSLS 127

  Fly   129 NGTLDDMVT--------AAHAITATVADEMRDQRKIVKKIINFMLNHEGGKLYVTKPVGEWIFEG 185
            .||.:|..|        |.|..|          ...|:.::|.::......::.|:.:.|.:: |
  Rat   128 VGTENDNFTVLNLAVAAAPHIYT----------NSFVQGVLNSLIKKSKSSMFQTRSLKELLW-G 181

  Fly   186 YQDNITDFLNLF-----NTTKIDIPYKRFGWLADRNESLTYDGLFTIHTGTDDISNLGRLTHWNG 245
            |:|   .||:|.     .|..:..||..           |.||::.:..|.|:||.:..:..:.|
  Rat   182 YKD---PFLSLVPYPISTTVGVFYPYNN-----------TVDGVYKVFNGKDNISKVAIIDTYKG 232

  Fly   246 KSETGFYEMPCGIVNGTTGDMFPPKMNVNDEITIFATDACRF--------MNLRPRGTYENHGLT 302
            |....::|..|.::|||....|||.:..:..:..|::|.||.        :||:        |:.
  Rat   233 KRNLSYWESYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEVNLK--------GIP 289

  Fly   303 ATKWVGTEETLDSGENYPNQACFCDEARF-DECPKTGVVECKACRDKAPIYSSFPHFYLADQSYV 366
            ..::|.......|....|:..|||.|... :.|...||::...|::..|:|.|.|||..|.....
  Rat   290 VYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVS 354

  Fly   367 DAVSGMKPEKEKHEFFLAVEPITGVPVQVHGRIQINMMIEPDDDFDIYRGVQK-VLMPMFWF--- 427
            :.:.|:.|.:::|..:|.||||||..:|...|:|:|::::|....:..:.::: .::|:.|.
  Rat   355 EPIEGLNPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNET 419

  Fly   428 ----DQYAEL-SSELASKAKLAINLSSYGIIFGYSMIAFASVFLIT 468
                |:.||: .:::..|.|| :.|... ::.|..::.|.: |:|:
  Rat   420 GTIGDEKAEMFRNQVTGKIKL-LGLVEM-VLLGVGVVMFVA-FMIS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crq	NP_001245823.1	CD36	19..470	CDD:307331	119/484 (25%)
Cd36	NP_113749.2	CD36	14..463	CDD:395898	120/490 (24%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		7/27 (26%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920