Protein Alignment ex and FRMD1

DIOPT Version :10

• Sequence 1: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 157/656 - (23%)
• Similarity: 247/656 - (37%)
• Gaps: 152/656 - (23%)

  Fly     2 RAFCTVSAP-LEVCASSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQ 65
            |..|:...| |.:.|.::|.     |.:.:.|..::|   |...|..|:..||::.|.|   ...
Human    76 RPACSQQEPTLGMDAMASEH-----RDVLVLLPSREQ---LRLAVGVKATGRELFQQVC---NVA 129

  Fly    66 GMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPF 130
            .:.|.:.|||.|:.:.||:|.|.|.|||||..|.|:.....|.:....|.:.. .|||.|:|:..
Human   130 SIRDAQFFGLCVVRNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRAPFVAF-LRVQHYVENGR 193

  Fly   131 MLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLAGLALQADLGDAPPGTSNSKDDSGEETSA 195
            ::.|..:||.||..|:..:|:......  |:|...||..|||||||:                ..
Human   194 VISDHRARHLYYCHLKERVLRSQCAHR--EEAYFLLAACALQADLGE----------------HR 240

  Fly   196 SPSNGGRGLSATTTLPK--ISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLP 258
            ..::.||.....:..|:  |:||..:.:||
Human   241 ESAHAGRYFEPHSYFPQWIITKRGIDYILR----------------------------------- 270

  Fly   259 SGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVV 323
               |.|       ..|||..|::..||.|.:||:||.| |.:..|.:|:...|.| |..:....:
Human   271 ---HMP-------TLHRERQGLSPKEAMLCFIQEACRL-EDVPVHFFRLHKDKKE-GRPTVILGL 323

  Fly   324 YAKGIKILGGESTNSSSNPETTTFL-WPNITKLSFERKKFEIR----SGESRITLYAASDEKNKL 383
            ..:|:.|.    ......|:....| ||::.||:|..||.||:    ....::..|.....:::.
Human   324 ALRGVHIY----QEVDRAPQLLYDLPWPHVGKLAFLGKKLEIQLDGLPAAQKLVYYTGCTWRSRH 384

  Fly   384 LLTLCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHASYACSRSLLLPYKSKNEQRISVIS--- 445
            ||.|.:.:||..:::...|:::  |:.|||.|.|....|| .|..|.|...|::.....|.|
Human   385 LLHLLRASHQLHLRVRPTLQQL--RQREEAEEKQHYRESY-ISDELELDLASRSFPGSGVSSQHC 446

  Fly   446 ----------STSSNTTSGIVSD---RVHSEDELEIMINTPPAPLAAPSTESLALAHLLDRPSVS 497
                      |..|:.||||.::   |...|..:::.:.........||:.          |..|
Human   447 PHCLSRHSADSHGSSYTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSSS----------PRTS 501

  Fly   498 RQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRNSMGTTANDSSTATDSPS---- 558
            |...|....|....:|....:..|.|.|.:       ...:|..:.|.:....|...|...
Human   502 RSHPSTRGDSQATRQEPCTQVRTRGQSAEA-------VHQIQEMTAGVSEEQHSHGLDDMQLHQL 559

  Fly   559 SQHNIGSQCSST------CSTVVVTSPVNGAGASSSGAPIPVHSTSSSLELGFSHTAQNSALSET 617
            :.|...:..|.|      |..         ||...:.|.:|...:|:.|.|        ....|.
Human   560 ALHPAPTSLSHTFHRALDCRL---------AGPCETRATLPSKRSSNCLAL--------DLFGEA 607

  Fly   618 SPDDFL 623
            .|.:|:
Human   608 PPQEFV 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	33/102 (32%)
		B41	27..297	CDD:214604	72/271 (27%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	26/111 (23%)
		PHA03255	512..>681	CDD:165513	22/122 (18%)
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	34/108 (31%)
		FERM_M	190..306	CDD:459788	43/179 (24%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	26/114 (23%)