Protein Alignment ex and frmd6

DIOPT Version :10

• Sequence 1: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_012824779.1
• Gene: frmd6 / 548781
• XenbaseID: XB-GENE-977939
• Length: 610
• Species: Xenopus tropicalis
• Alignment Length: 719
• Identity: 165/719 - (22%)
• Similarity: 273/719 - (37%)
• Gaps: 213/719 - (29%)

  Fly    40 TLYFLVDAKSRVREVYTQTC--LHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRS 102
            ||..:::.|:..:|:..|.|  ||     :.|..||||:|:.:.|:::.:...||.||.||.|:.
 Frog    27 TLNIIINVKALCQELLEQVCDLLH-----LRDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKK 86

  Fly   103 SHTHGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLA 167
            ..:.|:|..|.|:: :|||||:|:|:..::.|.|:|:.||..||..:|....  .|.|:|...||
 Frog    87 EASKGIDQFGPPMI-IHFRVQYYVENGRLISDRTARYYYYCHLRKQVLHSQC--MQREEAYFLLA 148

  Fly   168 GLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPK--ISKRANERMLRLSTYVAS 230
            ..|||||||       |.|.:         .:.|:........|.  |.||
 Frog   149 AFALQADLG-------NFKRN---------KHYGKYFEPEAYFPSWVIKKR-------------- 183

  Fly   231 TSKRETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRACHREHLGMATAEAELLYIQQACS 295
                            |.||  |..::|:             .||:...:..:||.|:||::|..
 Frog   184 ----------------GKDY--ILKHIPN-------------IHRDQFALTVSEAHLMYIKEAAR 217

  Fly   296 LHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETT---TFLWPNITKLSF 357
            | :.:..|.|::...|.|. ..|....:..:||:|.      .||:.|..   .|.|.|:.||.|
 Frog   218 L-DDVAVHYYKLYKDKKEM-EASLMLGLTLRGIQIF------QSSDDEKQLLYDFPWTNVGKLVF 274

  Fly   358 ERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKREEEEAAESQR 418
            ..|||||    .....::..|.....:::.||.|..::|:..|.|...|::|.|.||.|
 Frog   275 VGKKFEILPDGLPSARKLIYYTGCSVRSRHLLQLLSNSHRLYMNLQPVLRQVRKLEEHE------ 333

  Fly   419 LHASYACSRSLLLPYKSKNEQRISVISSTSSNTTSGIVSDRVHSEDELEIMINTPPAPLAAPSTE 483
                            .|.:.|.|.||.|
 Frog   334 ----------------EKKQYRESYISDT------------------------------------ 346

  Fly   484 SLALAHLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRNSMGTTAN 548
                                       |::.:..|..|.: ||.:.|..|.:..:.|:|..:.::
 Frog   347 ---------------------------LDQDMDQLEKRSR-ASGSSAGSVKHKRLSRHSTASHSS 383

  Fly   549 DSSTATDSPSSQHNIGSQCS----------STCSTVVVTSPVNGAGASSSGAP-IPVHSTSSSLE 602
            ..::..::.:...:||.:.|          .|||::...|..:.:||.|:|.. :...|....:|
 Frog   384 SHTSGIEADTKHRDIGPEDSFSGTSLHRKLKTCSSMTSNSSSHTSGAESAGKDRLEDDSQEDEIE 448

  Fly   603 LGFSHTAQNSALSETSPDDFLSTSAREE---TESVSGASGVYTLAHGAPPTETSGVYTMHSSELT 664
            :............:.|||  |.....|:   ::.::|.||:......:..:.:|....    :|.
 Frog   449 MLVDDPKDLDLPLDISPD--LCIYITEDMLVSQQLNGHSGLVVKEVNSSTSSSSETVV----KLR 507

  Fly   665 GQSSEIAESEKSSHYGMFQPQ----KLEETHVQHSDSVDGKK--KEDFRPRSDSNVSTGSSFR-G 722
            |||.:..            ||    |.:.:..:||.|:|..:  ::||...:..|..|..|:. |
 Frog   508 GQSIDSI------------PQTACRKPKTSTDRHSLSLDDIRLYQKDFLQIAGLNQETAQSYTFG 560

  Fly   723 DGSD 726
            .|.|
 Frog   561 CGHD 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	32/89 (36%)
		B41	27..297	CDD:214604	73/260 (28%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	30/113 (27%)
		PHA03255	512..>681	CDD:165513	34/182 (19%)
frmd6	XP_012824779.1	FERM_F1_FRMD6	15..112	CDD:340718	33/90 (37%)
		B41	20..226	CDD:214604	75/268 (28%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	30/114 (26%)