DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ex and frmd6

DIOPT Version :9

Sequence 1:	NP_001259823.1	Gene:	ex / 33218	FlyBaseID:	FBgn0004583	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_012824779.1	Gene:	frmd6 / 548781	XenbaseID:	XB-GENE-977939	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	719	Identity:	165/719 - (22%)
Similarity:	273/719 - (37%)	Gaps:	213/719 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TLYFLVDAKSRVREVYTQTC--LHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRS 102
            ||..:::.|:..:|:..|.|  ||     :.|..||||:|:.:.|:::.:...||.||.||.|:.
Frog    27 TLNIIINVKALCQELLEQVCDLLH-----LRDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKK 86

  Fly   103 SHTHGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLA 167
            ..:.|:|..|.|:: :|||||:|:|:..::.|.|:|:.||..||..:|....  .|.|:|...||
Frog    87 EASKGIDQFGPPMI-IHFRVQYYVENGRLISDRTARYYYYCHLRKQVLHSQC--MQREEAYFLLA 148

  Fly   168 GLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPK--ISKRANERMLRLSTYVAS 230
            ..|||||||       |.|.:         .:.|:........|.  |.||
Frog   149 AFALQADLG-------NFKRN---------KHYGKYFEPEAYFPSWVIKKR-------------- 183

  Fly   231 TSKRETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRACHREHLGMATAEAELLYIQQACS 295
                            |.||  |..::|:             .||:...:..:||.|:||::|..
Frog   184 ----------------GKDY--ILKHIPN-------------IHRDQFALTVSEAHLMYIKEAAR 217

  Fly   296 LHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETT---TFLWPNITKLSF 357
            | :.:..|.|::...|.|. ..|....:..:||:|.      .||:.|..   .|.|.|:.||.|
Frog   218 L-DDVAVHYYKLYKDKKEM-EASLMLGLTLRGIQIF------QSSDDEKQLLYDFPWTNVGKLVF 274

  Fly   358 ERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKREEEEAAESQR 418
            ..|||||    .....::..|.....:::.||.|..::|:..|.|...|::|.|.||.|
Frog   275 VGKKFEILPDGLPSARKLIYYTGCSVRSRHLLQLLSNSHRLYMNLQPVLRQVRKLEEHE------ 333

  Fly   419 LHASYACSRSLLLPYKSKNEQRISVISSTSSNTTSGIVSDRVHSEDELEIMINTPPAPLAAPSTE 483
                            .|.:.|.|.||.|
Frog   334 ----------------EKKQYRESYISDT------------------------------------ 346

  Fly   484 SLALAHLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRNSMGTTAN 548
                                       |::.:..|..|.: ||.:.|..|.:..:.|:|..:.::
Frog   347 ---------------------------LDQDMDQLEKRSR-ASGSSAGSVKHKRLSRHSTASHSS 383

  Fly   549 DSSTATDSPSSQHNIGSQCS----------STCSTVVVTSPVNGAGASSSGAP-IPVHSTSSSLE 602
            ..::..::.:...:||.:.|          .|||::...|..:.:||.|:|.. :...|....:|
Frog   384 SHTSGIEADTKHRDIGPEDSFSGTSLHRKLKTCSSMTSNSSSHTSGAESAGKDRLEDDSQEDEIE 448

  Fly   603 LGFSHTAQNSALSETSPDDFLSTSAREE---TESVSGASGVYTLAHGAPPTETSGVYTMHSSELT 664
            :............:.|||  |.....|:   ::.::|.||:......:..:.:|....    :|.
Frog   449 MLVDDPKDLDLPLDISPD--LCIYITEDMLVSQQLNGHSGLVVKEVNSSTSSSSETVV----KLR 507

  Fly   665 GQSSEIAESEKSSHYGMFQPQ----KLEETHVQHSDSVDGKK--KEDFRPRSDSNVSTGSSFR-G 722
            |||.:..            ||    |.:.:..:||.|:|..:  ::||...:..|..|..|:. |
Frog   508 GQSIDSI------------PQTACRKPKTSTDRHSLSLDDIRLYQKDFLQIAGLNQETAQSYTFG 560

  Fly   723 DGSD 726
            .|.|
Frog   561 CGHD 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_001259823.1	B41	27..297	CDD:214604	73/260 (28%)
		FERM_N	40..98	CDD:286467	19/59 (32%)
		FERM_M	132..305	CDD:278785	42/174 (24%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	30/113 (27%)
		PHA03255	512..>681	CDD:165513	34/182 (19%)
frmd6	XP_012824779.1	FERM_F1_FRMD6	15..112	CDD:340718	33/90 (37%)
		B41	20..226	CDD:214604	75/268 (28%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	30/114 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171513at33208
OrthoFinder	1	1.000	-	-		FOG0004598
OrthoInspector	1	1.000	-	-		oto104070
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4456
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950