DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ex and frmd6

DIOPT Version :9

Sequence 1:	NP_001259823.1	Gene:	ex / 33218	FlyBaseID:	FBgn0004583	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_001018652.1	Gene:	frmd6 / 321937	ZFINID:	ZDB-GENE-050522-354	Length:	616	Species:	Danio rerio

Alignment Length:	687	Identity:	164/687 - (23%)
Similarity:	257/687 - (37%)	Gaps:	204/687 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSS 103
            :||..:|..|:..:|:..|.|   ....:.|..||||:|:.:.|:::.:...||||:.||.|:..
Zfish    26 ETLNVIVSVKTVCQELLVQVC---DLLRLKDCHLFGLSVIQNNEHIYMELGQKLSKHCPKEWKRE 87

  Fly   104 HTHGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLAG 168
            .:.|:|..|.|:: :|||.|:|:|:..::.|..:|:.||..||..:||...  .|.|:|...||.
Zfish    88 ASKGIDQFGPPMI-VHFRAQYYVENGRLISDRVARYYYYWHLRKQVLQSQC--IQREEAYFLLAA 149

  Fly   169 LALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPKISKRANERMLRLSTYVASTSK 233
            .|||||||:.                                     :.|:..
Zfish   150 FALQADLGNF-------------------------------------KRNKHF------------ 165

  Fly   234 RETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRAC----------HREHLGMATAEAELL 288
                         || |::.|.|.||     |. .|.|.|          |:|......:||:|.
Zfish   166 -------------GA-YFQPEAYFPS-----WV-IAKRGCDYILRHIPNMHKEQFACTASEAQLK 210

  Fly   289 YIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETT-----TFL 348
            ||::| :|.:.:..|.||:...|.|. ..|....:..:||:|.        .|..|.     .|.
Zfish   211 YIKEA-TLLDDVAVHYYRLYKDKKEL-DASLTLGLTLRGIQIF--------QNVGTVRQLLYDFP 265

  Fly   349 WPNITKLSFERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKRE 409
            |.|:.||.|..|:|||    .....::..|.....:::.||.|..::|:..|.|...||:|.:.|
Zfish   266 WTNVGKLVFVGKRFEILPDGLPSARKLIYYTGCPLRSRHLLQLLSNSHRLYMNLQPVLKQVRRLE 330

  Fly   410 EEE------------AAES------QRLHASYACSRSLLLP-------YKSKNEQRISVISS--- 446
            |.|            |.|:      ||..||.:.:.|...|       ..|....|.|.:.:
Zfish   331 ENEEKKQYRESYIGDALEADMDHLEQRSRASGSSAGSTSRPNPFSRHSTTSHGSSRTSGVDTDSF 395

  Fly   447 --------------TSSNT------TSGI-VSDRVH--SEDELEIMINTPPAPLAAPSTESLALA 488
                          :||||      |||| .|.:.|  .|||:|::::.|.   :....:.|.|:
Zfish   396 RTPTNTPHRPLRTHSSSNTSHASTHTSGIESSSKEHCLDEDEIEMLVDDPK---SCEDLDDLELS 457

  Fly   489 -----HLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIV--TNSSVQRNSMGTT 546
                 |:.: ..:|.|.:....:.:|::.          ...||:..|:|  ...|::.....|.
Zfish   458 QELCIHITE-DMLSAQNNGCSGLVVKEVS----------SSTSSSSETVVRMRGQSIECLPQTTM 511

  Fly   547 ANDSSTATDSPSSQ-----------HNIGSQCSSTC-STVVVTSPVNG--------------AGA 585
            |....::||..|..           ......|..|. |......|..|              ||.
Zfish   512 ARKGQSSTDRHSQSLDDVRLFQRDCQEWAELCQDTAHSYTFGCEPDLGGTVGCGYQGLADQCAGI 576

  Fly   586 SSSGAPIPVHSTSS--SLELGFSHTAQNSALSETSPD 620
            .::..|.|:..||.  ||:|...........:|..|:
Zfish   577 RNNQHPFPIKRTSKYFSLDLDREDLTTGHLTTEAEPE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_001259823.1	B41	27..297	CDD:214604	71/267 (27%)
		FERM_N	40..98	CDD:286467	18/57 (32%)
		FERM_M	132..305	CDD:278785	42/182 (23%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	30/115 (26%)
		PHA03255	512..>681	CDD:165513	26/139 (19%)
frmd6	NP_001018652.1	B41	20..215	CDD:214604	70/263 (27%)
		FERM_N	20..82	CDD:286467	18/58 (31%)
		FERM_M	115..226	CDD:278785	42/182 (23%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	30/116 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171513at33208
OrthoFinder	1	1.000	-	-		FOG0004598
OrthoInspector	1	1.000	-	-		oto39243
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4456
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950