Protein Alignment ex and Frmd6

DIOPT Version :10

• Sequence 1: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_082403.2
• Gene: Frmd6 / 319710
• MGIID: 2442579
• Length: 622
• Species: Mus musculus
• Alignment Length: 694
• Identity: 151/694 - (21%)
• Similarity: 247/694 - (35%)
• Gaps: 230/694 - (33%)

  Fly    39 KTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSS 103
            |::..:::.|....::..|.|   ....:.|:.||||:|:.:.|:::.:...||.||.||.|:..
Mouse    26 KSVSIIINVKILCHQLLVQVC---DLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKE 87

  Fly   104 H--------THGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAE 160
            .        |.|:|..|.|:: :|||||:|:|:..::.|..:|:.||..||..:|.......  |
Mouse    88 ASKVRQYEVTWGIDQFGPPMI-IHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLR--E 149

  Fly   161 QALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPKISKRANERMLRLS 225
            :|...||..|||||||:
Mouse   150 EAYFLLAAFALQADLGN------------------------------------------------ 166

  Fly   226 TYVASTSKRETIPLPPSLPPNGADYYRIEDYLPSGL-----------HTPWARSAMRACHREHLG 279
                  .||:.         :..||:..|.|.|:.:           |.|       ..|::...
Mouse   167 ------FKRKL---------HHGDYFEPEAYFPAWVVSKRGKDYILKHIP-------NMHKDQFA 209

  Fly   280 MATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPET 344
            :..:||.|.||::|..| :.:..|.||:...|.| ..||....:..:||:|.    .|.....:.
Mouse   210 LTASEAYLKYIKEAVRL-DDVAIHYYRLYKDKRE-AEGSLTLGLTMRGIQIF----QNLEEEKQL 268

  Fly   345 T-TFLWPNITKLSFERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKE 404
            . .|.|.|:.||.|..|||||    .....::..|.....:::.||.|..::|:..|.|...|:.
Mouse   269 LYDFPWTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRH 333

  Fly   405 VSKREEEEAAESQRLHASY----------------ACSRSLLLPYKSKNEQRISVISSTSSNT-- 451
            :.|:||.|  |.::...||                ..|.|.....|.|...|.|..|.:||:|
Mouse   334 LRKQEENE--EKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSVKHKRLSRHSTASHSSSHTSG 396

  Fly   452 --------------------------------------TSGIVS---DRVH---SEDELEIMINT 472
                                                  |||:.|   ||:.   .::|:|::::.
Mouse   397 IEADTKPRDPGPEDSCSGSAMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQDEEIEMLVDD 461

  Fly   473 P----PAPLAAPSTESLALA-----HLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSN 528
            |    |.|     .|||.::     ::.:...:||:.:....:.:|::          ....||:
Mouse   462 PRDLEPMP-----EESLEVSPEMCIYITEDMLLSRKLNGHSGLIVKEI----------GSSTSSS 511

  Fly   529 GATIVTNSSVQRNSM-GTTANDSSTATDSPSSQHN-----------IGSQCSST----------- 570
            ..|:|.......:|: .|......|:||..|...:           |...|..|
Mouse   512 SETVVRLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHE 576

  Fly   571 -------CSTVVVTSPVNGAGASSSGAPIPVHSTSSSLELGFSH 607
                   |::.:....||...|      .||...|....|..:|
Mouse   577 LDESGLYCNSCLAQQCVNIQDA------FPVKRASKYFSLDLTH 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	29/96 (30%)
		B41	27..297	CDD:214604	64/276 (23%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	30/111 (27%)
		PHA03255	512..>681	CDD:165513	22/126 (17%)
Frmd6	NP_082403.2	Ubl1_cv_Nsp3_N-like	15..120	CDD:475130	30/97 (31%)
		FERM_M	118..234	CDD:459788	37/188 (20%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	30/112 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..452		16/94 (17%)