DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ex and Frmd6

DIOPT Version :9

Sequence 1:	NP_001259823.1	Gene:	ex / 33218	FlyBaseID:	FBgn0004583	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	XP_006240213.1	Gene:	Frmd6 / 257646	RGDID:	727810	Length:	622	Species:	Rattus norvegicus

Alignment Length:	690	Identity:	153/690 - (22%)
Similarity:	246/690 - (35%)	Gaps:	222/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSS 103
            |::..:::.|....::..|.|   ....:.|:.||||:|:.:.|:::.:...||.||.||.|:..
  Rat    26 KSVSIIINVKILCHQLLVQVC---DLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKE 87

  Fly   104 H--------THGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAE 160
            .        |.|:|..|.|:: :|||||:|:|:..::.|..:|:.||..||..:|.......  |
  Rat    88 ASKVRQYEVTWGIDQFGPPMI-IHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLR--E 149

  Fly   161 QALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPKISKRANERMLRLS 225
            :|...||..|||||||:
  Rat   150 EAYFLLAAFALQADLGN------------------------------------------------ 166

  Fly   226 TYVASTSKRETIPLPPSLPPNGADYYRIEDYLPSGL-----------HTPWARSAMRACHREHLG 279
                  .||:.         :..||:..|.|.|:.:           |.|       ..||:...
  Rat   167 ------FKRKV---------HHGDYFEPEAYFPAWVVSKRGKDYILKHIP-------NMHRDQFA 209

  Fly   280 MATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPET 344
            :..:||.|.||::|..| :.:..|.||:...|.|. .||....:..:||:|.    .|.....:.
  Rat   210 LTASEAYLKYIKEAVRL-DDVAIHYYRLYKDKREV-EGSLTLGLTMRGIQIF----QNLEEEKQL 268

  Fly   345 T-TFLWPNITKLSFERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKE 404
            . .|.|.|:.||.|..|||||    .....::..|.....:::.||.|..::|:..|.|...|:.
  Rat   269 LYDFPWTNVGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRH 333

  Fly   405 VSKREEEEAAESQRLHASY----------------ACSRSLLLPYKSKNEQRISVISSTSSNT-- 451
            :.|:||.|  |.::...||                ..|.|.....|.|...|.|..|.:||:|
  Rat   334 LRKQEENE--EKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSG 396

  Fly   452 --------------------------------------TSGIVS---DRVH---SEDELEIMINT 472
                                                  |||:.|   ||:.   .:||:|::::
  Rat   397 IETDTKPRDPGPEDGYSGSVMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQDDEIEMLVD- 460

  Fly   473 PPAPLAAPSTESLALA-----HLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATI 532
            .|..|...:.|||.::     ::.....:||:.:....:.:|::.          ...||:..|:
  Rat   461 DPRDLEPMTEESLEVSPEMCIYITQDMLLSRKLNGHSGLIVKEIS----------SSTSSSSETV 515

  Fly   533 VTNSSVQRNSM-GTTANDSSTATDSPSSQHN-----------IGSQCSST--------------- 570
            |.......:|: .|......|:||..|...:           |...|..|
  Rat   516 VKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDES 580

  Fly   571 ---CSTVVVTSPVNGAGASSSGAPIPVHSTSSSLELGFSH 607
               |.:.:....||...|      .||..||....|..:|
  Rat   581 GLYCDSCLAQQCVNMHDA------FPVKRTSKYFSLDLTH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_001259823.1	B41	27..297	CDD:214604	65/276 (24%)
		FERM_N	40..98	CDD:286467	14/57 (25%)
		FERM_M	132..305	CDD:278785	37/183 (20%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	30/111 (27%)
		PHA03255	512..>681	CDD:165513	23/126 (18%)
Frmd6	XP_006240213.1	B41	20..234	CDD:214604	67/284 (24%)
		FERM_N	20..82	CDD:286467	15/58 (26%)
		FERM_M	123..234	CDD:278785	37/183 (20%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	30/112 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4371
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171513at33208
OrthoFinder	1	1.000	-	-		FOG0004598
OrthoInspector	1	1.000	-	-		oto97386
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820