Protein Alignment ex and frm-7

DIOPT Version :10

• Sequence 1: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: NP_506085.2
• Gene: frm-7 / 179687
• WormBaseID: WBGene00001493
• Length: 947
• Species: Caenorhabditis elegans
• Alignment Length: 1128
• Identity: 257/1128 - (22%)
• Similarity: 391/1128 - (34%)
• Gaps: 350/1128 - (31%)

  Fly    16 SSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVL-- 78
            :|...:.||..|::::.|.::   :.:..:.:|::|.:|..:.....:   :.|.:|||||..
 Worm    34 TSTHNIRPGQTFVSVQTLTKE---SFHVAISSKTKVHDVLWKCGERLS---LSDDKLFGLAFRQP 92

  Fly    79 ---IDG-----EYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPFMLKDE 135
               |.|     ||.|.||.:|:.||..|..|.::.|...:..||:|.|:|||:.||:...:|...
 Worm    93 TEGIGGDQPRHEYYFLDPAAKIMKYAQKQPRFANWHSKSSENRPILVLYFRVRVYIDQVGLLSCP 157

  Fly   136 TSRHNYYLQLRHNILQRDLPREQ-AEQALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSN 199
            .:|.:|||||:.|.|.....|.. :|:...::|.|||..|.|:...|
 Worm   158 KAREHYYLQLKDNFLDHWAGRNSVSEERCWYMAALALITDKGNDYLG------------------ 204

  Fly   200 GGRGLSATTTLPKISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLP------ 258
                                                              |:|.|.|.|
 Worm   205 --------------------------------------------------YFRAEQYFPLWVINE 219

  Fly   259 SGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVV 323
            .||.  :.|:.:.|...:.:.....:|...::.:|......:|.|.|.:|..|.: .:.:|...:
 Worm   220 RGLE--YIRNNLPAACEDIINEGRYKAMEKFMIEAGRSPFALNCHLYGLRRHKMD-NTDNAVLGI 281

  Fly   324 YAKGIKILG-GESTNSSSNPETTTFLWPNITKLSFERKKFE-IRSGESRITLYAASDEKNKLLLT 386
            .||||::.. ||   ........:..|..:.||||.|||.. |.|..::::|||.::.|.|.||.
 Worm   282 NAKGIEMCDIGE---DGDRIPLRSLSWSRVAKLSFNRKKMTIIGSDGTKMSLYAQTEHKAKYLLE 343

  Fly   387 LCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHASYACSRSLLLPYKSKNEQRISVISSTS--- 448
            |||..||..:.::                  .|||:.|....   ||...:...||. ||||
 Worm   344 LCKAVHQTLLVMS------------------HLHATMAPPPK---PYLEMSVDGIST-SSTSGIG 386

  Fly   449 -------SNTTSGIVSDRVHSEDELEIMINTPPAPLAAPSTESLALAHLLDRPSVSRQTSSVGQM 506
                   |::.|....||.|.....::.:............|.:.|.|:       ||..:..|.
 Worm   387 SGDHDKDSDSLSSACGDRCHGSMSSKLRLRIKMDSNLDVKIEKMELDHI-------RQERAASQS 444

  Fly   507 SLKDLEEQLAALSVRPQD----ASSNGATIVTNSSVQRNSMGTTANDSSTATDSPSSQHNIGSQC 567
            |....|.:.:.|.||.|.    ...:|||..|.:.       |||.|::|   .|||..|.....
 Worm   445 SKASDESERSRLEVRHQTYHPAHELSGATSSTYTV-------TTAQDTAT---RPSSMDNASQTI 499

  Fly   568 SSTCSTVVVTSPVNG-------AGASSSGA-----------PIPVHSTSSSLELGF---SHTAQ- 610
            .|..|..:|....|.       :..|:||.           ||.....||::.:..   |.|.|
 Worm   500 ESGSSRSIVDVNFNNKNRERHESSTSTSGTHVLFSSKDATPPIETAVVSSTMSMSVPLDSDTNQS 564

  Fly   611 -NSALSETSPDDFLSTSAREETESVSGASGVYTLAHGAPPTETSGVYTMHSSELTGQSSEIAESE 674
             |..|...|..|..:.:.|..:......:.|.:....:||.      .|...:||...:.|
 Worm   565 INDRLLSMSASDLRAMAERSYSPPAQWTTNVPSTGSSSPPE------MMARDKLTRSETRI---- 619

  Fly   675 KSSHYGMFQPQKLEETHVQHSDSVDGKKKEDFRPRSDSNVSTGSSFRGDGSDPTD--------NK 731
             .|...|:..|.:|..:       .|.....|..::.|.....::.....|.|:.        |.
 Worm   620 -DSQNEMWLNQPVESFN-------GGGTAGRFVKKNSSGNRNANAINRVHSMPSHYHVNGYYRNS 676

  Fly   732 HSLLSAEELTNLIVGRGTYPSRKTVSSSLHSDCDYVTLPLGDQGEEEVDQPPAPPPPYSARHEKT 796
            :.:|:.|:..   :..|  |:..|.:.|||       :| |....      |..||||.:..:
 Worm   677 NQILTYEDAP---IHHG--PTLLTHAQSLH-------VP-GTVAR------PRNPPPYESTFQ-- 720

  Fly   797 GLCGPPIAKPIPKPIAVVAPKPDS--PPCSPP---VPPAPIPAPPPAIRRRDPPPYSISSKPRPT 856
                         ||..|.||..|  ||.|.|   ....|:||.....|:...||.|::    ||
 Worm   721 -------------PIFAVGPKTSSSPPPQSQPSLTASTGPLPAEIAGDRQASFPPASVT----PT 768

  Fly   857 SLISVSSSAHPAPSAAGSMSSLKSEEVTARFITTRPQI-SILKAHTS--------LIPDGAKPSY 912
            ..:          ..||:.|:.|.|..        |.| .:||.|..        .:.:|...|.
 Worm   769 QFL----------EEAGAFSTEKMENY--------PLILQLLKEHRQSQGQLNAITMTNGIYNSS 815

  Fly   913 AA--------PHHCSSVASSNGSVC-----------------SHQLSQQSLHNSNYAGGS----- 947
            .|        |..|:.::|.:|.|.                 |..|| |:||.|::...:
 Worm   816 QAGILSHNRRPSSCNDLSSLDGGVINGGAFVLPTHRGDYYFDSATLS-QNLHLSSFVPMTTSTTT 879

  Fly   948 -----------QASLHHHHV-PSHHRHSGSAAIGIVPYGLHKSTASLHHQQSCVLLPVIKPR--- 997
                       .||.|...: ||...|.                 .|.||||      |||.
 Worm   880 TSSATMTSSLITASSHQQPLQPSQQHHQ-----------------QLQHQQS------IKPTNNF 921

  Fly   998 --------QFLAPPPPSLPRQPP 1012
                    ..:.||||  |.|.|
 Worm   922 ARIEQHNGDLILPPPP--PYQQP 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	33/112 (29%)
		B41	27..297	CDD:214604	62/286 (22%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	34/108 (31%)
		PHA03255	512..>681	CDD:165513	45/195 (23%)
frm-7	NP_506085.2	B41	45..269	CDD:214604	66/299 (22%)
		FERM_C_FRMD1_FRMD6	257..362	CDD:270006	37/126 (29%)