DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ex and frm-7

DIOPT Version :9

Sequence 1:	NP_001259823.1	Gene:	ex / 33218	FlyBaseID:	FBgn0004583	Length:	1427	Species:	Drosophila melanogaster
Sequence 2:	NP_506085.2	Gene:	frm-7 / 179687	WormBaseID:	WBGene00001493	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	1128	Identity:	257/1128 - (22%)
Similarity:	391/1128 - (34%)	Gaps:	350/1128 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVL-- 78
            :|...:.||..|::::.|.::   :.:..:.:|::|.:|..:.....:   :.|.:|||||..
Worm    34 TSTHNIRPGQTFVSVQTLTKE---SFHVAISSKTKVHDVLWKCGERLS---LSDDKLFGLAFRQP 92

  Fly    79 ---IDG-----EYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPFMLKDE 135
               |.|     ||.|.||.:|:.||..|..|.::.|...:..||:|.|:|||:.||:...:|...
Worm    93 TEGIGGDQPRHEYYFLDPAAKIMKYAQKQPRFANWHSKSSENRPILVLYFRVRVYIDQVGLLSCP 157

  Fly   136 TSRHNYYLQLRHNILQRDLPREQ-AEQALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSN 199
            .:|.:|||||:.|.|.....|.. :|:...::|.|||..|.|:...|
Worm   158 KAREHYYLQLKDNFLDHWAGRNSVSEERCWYMAALALITDKGNDYLG------------------ 204

  Fly   200 GGRGLSATTTLPKISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLP------ 258
                                                              |:|.|.|.|
Worm   205 --------------------------------------------------YFRAEQYFPLWVINE 219

  Fly   259 SGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVV 323
            .||.  :.|:.:.|...:.:.....:|...::.:|......:|.|.|.:|..|.: .:.:|...:
Worm   220 RGLE--YIRNNLPAACEDIINEGRYKAMEKFMIEAGRSPFALNCHLYGLRRHKMD-NTDNAVLGI 281

  Fly   324 YAKGIKILG-GESTNSSSNPETTTFLWPNITKLSFERKKFE-IRSGESRITLYAASDEKNKLLLT 386
            .||||::.. ||   ........:..|..:.||||.|||.. |.|..::::|||.::.|.|.||.
Worm   282 NAKGIEMCDIGE---DGDRIPLRSLSWSRVAKLSFNRKKMTIIGSDGTKMSLYAQTEHKAKYLLE 343

  Fly   387 LCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHASYACSRSLLLPYKSKNEQRISVISSTS--- 448
            |||..||..:.::                  .|||:.|....   ||...:...||. ||||
Worm   344 LCKAVHQTLLVMS------------------HLHATMAPPPK---PYLEMSVDGIST-SSTSGIG 386

  Fly   449 -------SNTTSGIVSDRVHSEDELEIMINTPPAPLAAPSTESLALAHLLDRPSVSRQTSSVGQM 506
                   |::.|....||.|.....::.:............|.:.|.|:       ||..:..|.
Worm   387 SGDHDKDSDSLSSACGDRCHGSMSSKLRLRIKMDSNLDVKIEKMELDHI-------RQERAASQS 444

  Fly   507 SLKDLEEQLAALSVRPQD----ASSNGATIVTNSSVQRNSMGTTANDSSTATDSPSSQHNIGSQC 567
            |....|.:.:.|.||.|.    ...:|||..|.:.       |||.|::|   .|||..|.....
Worm   445 SKASDESERSRLEVRHQTYHPAHELSGATSSTYTV-------TTAQDTAT---RPSSMDNASQTI 499

  Fly   568 SSTCSTVVVTSPVNG-------AGASSSGA-----------PIPVHSTSSSLELGF---SHTAQ- 610
            .|..|..:|....|.       :..|:||.           ||.....||::.:..   |.|.|
Worm   500 ESGSSRSIVDVNFNNKNRERHESSTSTSGTHVLFSSKDATPPIETAVVSSTMSMSVPLDSDTNQS 564

  Fly   611 -NSALSETSPDDFLSTSAREETESVSGASGVYTLAHGAPPTETSGVYTMHSSELTGQSSEIAESE 674
             |..|...|..|..:.:.|..:......:.|.:....:||.      .|...:||...:.|
Worm   565 INDRLLSMSASDLRAMAERSYSPPAQWTTNVPSTGSSSPPE------MMARDKLTRSETRI---- 619

  Fly   675 KSSHYGMFQPQKLEETHVQHSDSVDGKKKEDFRPRSDSNVSTGSSFRGDGSDPTD--------NK 731
             .|...|:..|.:|..:       .|.....|..::.|.....::.....|.|:.        |.
Worm   620 -DSQNEMWLNQPVESFN-------GGGTAGRFVKKNSSGNRNANAINRVHSMPSHYHVNGYYRNS 676

  Fly   732 HSLLSAEELTNLIVGRGTYPSRKTVSSSLHSDCDYVTLPLGDQGEEEVDQPPAPPPPYSARHEKT 796
            :.:|:.|:..   :..|  |:..|.:.|||       :| |....      |..||||.:..:
Worm   677 NQILTYEDAP---IHHG--PTLLTHAQSLH-------VP-GTVAR------PRNPPPYESTFQ-- 720

  Fly   797 GLCGPPIAKPIPKPIAVVAPKPDS--PPCSPP---VPPAPIPAPPPAIRRRDPPPYSISSKPRPT 856
                         ||..|.||..|  ||.|.|   ....|:||.....|:...||.|::    ||
Worm   721 -------------PIFAVGPKTSSSPPPQSQPSLTASTGPLPAEIAGDRQASFPPASVT----PT 768

  Fly   857 SLISVSSSAHPAPSAAGSMSSLKSEEVTARFITTRPQI-SILKAHTS--------LIPDGAKPSY 912
            ..:          ..||:.|:.|.|..        |.| .:||.|..        .:.:|...|.
Worm   769 QFL----------EEAGAFSTEKMENY--------PLILQLLKEHRQSQGQLNAITMTNGIYNSS 815

  Fly   913 AA--------PHHCSSVASSNGSVC-----------------SHQLSQQSLHNSNYAGGS----- 947
            .|        |..|:.::|.:|.|.                 |..|| |:||.|::...:
Worm   816 QAGILSHNRRPSSCNDLSSLDGGVINGGAFVLPTHRGDYYFDSATLS-QNLHLSSFVPMTTSTTT 879

  Fly   948 -----------QASLHHHHV-PSHHRHSGSAAIGIVPYGLHKSTASLHHQQSCVLLPVIKPR--- 997
                       .||.|...: ||...|.                 .|.||||      |||.
Worm   880 TSSATMTSSLITASSHQQPLQPSQQHHQ-----------------QLQHQQS------IKPTNNF 921

  Fly   998 --------QFLAPPPPSLPRQPP 1012
                    ..:.||||  |.|.|
Worm   922 ARIEQHNGDLILPPPP--PYQQP 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_001259823.1	B41	27..297	CDD:214604	62/286 (22%)
		FERM_N	40..98	CDD:286467	19/67 (28%)
		FERM_M	132..305	CDD:278785	31/179 (17%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	34/108 (31%)
		PHA03255	512..>681	CDD:165513	45/195 (23%)
frm-7	NP_506085.2	B41	45..269	CDD:214604	66/299 (22%)
frm-7	NP_506085.2	FERM_C_FRMD1_FRMD6	257..362	CDD:270006	37/126 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164101
Domainoid	1	1.000	55	1.000	Domainoid score	I7473
eggNOG	1	0.900	-	-		E1_KOG4371
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I3009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004598
OrthoInspector	1	1.000	-	-		oto20000
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4456
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.920