Protein Alignment ex and ex

DIOPT Version :10

• Sequence 1: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Sequence 2: XP_061518329.1
• Gene: ex / 1280082
• VectorBaseID: AGAMI1_005923
• Length: 1600
• Species: Anopheles gambiae
• Alignment Length: 1680
• Identity: 818/1680 - (48%)
• Similarity: 990/1680 - (58%)
• Gaps: 367/1680 - (21%)

  Fly     1 MRAFCTVSAPLEVCASSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQ 65
            |||||||||||||||..:..|.||:|||||:|||..||:||||||:|||||||||.|||.||:.|
Mosquito     1 MRAFCTVSAPLEVCAPPSRPLPPGTRFLALKLLGTPQPRTLYFLVEAKSRVREVYAQTCHHFSKQ 65

  Fly    66 GMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPF 130
            ||||||||||||||||||:||||||||||||||||||||||||||||:||||||||||||||||.
Mosquito    66 GMLDTELFGLAVLIDGEYLFADPESKLSKYGPKSWRSSHTHGLDANGKPLLELHFRVQFYIESPL 130

  Fly   131 MLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLAGLALQADLGDAPP---GT---------- 182
            ||:||.|||||||||::|.:.||||:|.:||:|:.|.||:|||||||:.|   ||
Mosquito   131 MLRDEVSRHNYYLQLKYNAVNRDLPKECSEQSLLLLGGLSLQADLGDSAPEDAGTTLPTTPSIKT 195

  Fly   183 ----------------------------------SNSKDDSGEETSASPSNGGRGLSATTTLPKI 213
                                              |||...:...||::.|:.....|:||:....
Mosquito   196 ATSSTATVPCSSTANLNSTTGGGVLSSGVSVSSSSNSSSSASSNTSSATSSSTSSNSSTTSACSP 260

  Fly   214 SKRANERMLRLSTYVASTSKRETIPLPPSLPPN-------GA---------------DYYRIEDY 256
            :..|.......||..|::|...|...|| :.||       ||               :|:|.::|
Mosquito   261 NPSAGGAPSVSSTSTAASSACTTTSGPP-VQPNTNIAANDGASSSTTTTTTTSSPSVEYFRPDEY 324

  Fly   257 LPSGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWF 321
            |...|.:.|..:|:..|||::.|::.|:||..:|::||:|:|.:|||.:||:.:|:|.|.|:...
Mosquito   325 LNPALRSAWGIAAVTTCHRDNRGLSRADAETHFIREACNLNEAVNAHVFRMKQSKNETGLGTVAL 389

  Fly   322 VVYAKGIKIL-GGESTNSSSNPETTTFLWPNITKLSFERKKFEIRSGESRITLYAASDEKNKLLL 385
            .:|||||:|. .|.||       .|||.||:|.||||:|||||||||:|:||||:.:|:|||::|
Mosquito   390 SIYAKGIRIAQDGSST-------ATTFQWPHIGKLSFDRKKFEIRSGDSKITLYSTNDDKNKMIL 447

  Fly   386 TLCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHA-SYACSRSLLLPYKSKNEQRISVISSTSS 449
            .||::|||:|||:|.||.|..|||||   ||..:|. .|.|||:|.||||||::|||||||||||
Mosquito   448 ALCRETHQFSMKIAPRLTEAIKREEE---ESSCIHGYPYLCSRALNLPYKSKSDQRISVISSTSS 509

  Fly   450 NTTSGIVSDRVHSEDELEIMINTPP-APLAAPSTESLALAHLLDRPSVSRQTSSVGQMSLKDLEE 513
            ||||||||||||||||||||||||| |.||||||||||||||||.||||||||||||:|||:||.
Mosquito   510 NTTSGIVSDRVHSEDELEIMINTPPTATLAAPSTESLALAHLLDCPSVSRQTSSVGQVSLKELEG 574

  Fly   514 QLAALSVRPQDASSNGA-TIVTNSSVQRNSMGTTANDSST-----------ATDSPSSQHNIGSQ 566
            ..|||||....:..|.| ::|..||...|:.....:||.:           ...|||||||||||
Mosquito   575 TFAALSVGRTGSVVNAAGSLVPCSSGSSNTNNCANSDSGSVEGKPDRPGKECESSPSSQHNIGSQ 639

  Fly   567 CSSTCSTVVV----------------TSPVNGAGASSSGAPIPVH------STSSSLELGFSHTA 609
            ||||||||||                |:..||.|::|:.....:.      ||.|||.|||||||
Mosquito   640 CSSTCSTVVVATDCLSLPQSSTATSTTTISNGGGSNSTMVQATISPDRRQTSTCSSLVLGFSHTA 704

  Fly   610 QNSALSETSPDDFLSTSAREETESVSGASGVYTLAHGAPPTETSGVYTMHSSELTGQSSEIAESE 674
            |||.|| .:....|.....||.|...  |||||:|| .|||||||||||:|||||||||||||||
Mosquito   705 QNSTLS-VATSTCLDHDINEEEEETH--SGVYTIAH-VPPTETSGVYTMNSSELTGQSSEIAESE 765

  Fly   675 --KSSHYGMFQPQKLEETH-VQHSDSVDGK---------KKEDFRPRSDSNVSTGSSFRGDGSDP 727
              :|||||.|||.:.|... ::..|||||.         ...:||.||||.||...|||||||||
Mosquito   766 SHESSHYGSFQPCQSEMADPLEPVDSVDGDYHRPRLDSGLNSEFRMRSDSTVSAAGSFRGDGSDP 830

  Fly   728 TDNKHSLLSAEELTNLIVGRGTYPSRKTVSSSLHSDCDYVTLPLGDQG-------------EEEV 779
            ||||||||||||||:|||||||||||||||.:|.||||||||||..:|             |:|.
Mosquito   831 TDNKHSLLSAEELTDLIVGRGTYPSRKTVSHTLDSDCDYVTLPLPLEGESYLQGSEDTAPTEDEY 895

  Fly   780 D--------------------------------------------QPPAPPPPYSARHEKTGLCG 800
            |                                            |||.|||||:|.||.|||.|
Mosquito   896 DDEVLPPAPPKRIDSNMAAAVAAAVVPCPTRPPQLPQPPVELAQQQPPPPPPPYNAHHETTGLRG 960

  Fly   801 PPIAKPIPKPIAVVAPKPDSPPCSPPVPPAPIPAPPPAIRRRDPPPYSISSKPRPTSLISVSSSA 865
            |.|..                    |.|||......|||..||||||       |...|::..|.
Mosquito   961 PDIRS--------------------PAPPAATDPEAPAIPLRDPPPY-------PQKPIAMRKSP 998

  Fly   866 HPAPSAAGSMSSLK----SEEVTARFITTRPQISILKAHTSLIPDGAKPSYAAPHHCSSVASSNG 926
            ...|:...:.|.|.    ||||.||||||||||:|||||.|::.:..|||:|||
Mosquito   999 ILPPALPVTPSVLTTAPVSEEVPARFITTRPQINILKAHASVVGETPKPSFAAP----------- 1052

  Fly   927 SVCSHQLSQQSLHNSNYAGGSQASLHHHHVPSHHRHSGSAAIGIVPYGLHKSTASL--------- 982
                      :::|......:........||:          ||..|.||.:..::
Mosquito  1053 ----------TVNNIGNLAQATPPPPPPPVPT----------GIPGYNLHPNHKAITSPPPPYPE 1097

  Fly   983 ------HHQQSCVLLPVIKPRQFLAPPPPSLPRQPPPPPPPNHPHLASHLYEREMARKQLELYQQ 1041
                  |...:|||||||||||:..||||::|||||||||   ||..:.:|..::||.|:|||||
Mosquito  1098 MPKPPPHRTTACVLLPVIKPRQYHPPPPPTMPRQPPPPPP---PHSLATVYTSQLARSQIELYQQ 1159

  Fly  1042 QLYSDVDYVIYPIQDPAVSQQEYLDAKQGSLLAAMAQAAPPPPHHPYLAMQV---------SPAI 1097
            ||||||||||||||||::||||||||||||:||||||:.||||:..|..::.         :.||
Mosquito  1160 QLYSDVDYVIYPIQDPSISQQEYLDAKQGSILAAMAQSPPPPPYLAYHTVRAHNRSWDACKNHAI 1224

  Fly  1098 YRSTPYLPLTLSTHSRYASTQNLSDTYVQLPGPGYSPLYSPSMASLCSSYEPPPPPPLHPAALAA 1162
            |||||||.:.||::|||||||||||||||||| .||||||||:|||||||||||||||.|..:.:
Mosquito  1225 YRSTPYLSMALSSNSRYASTQNLSDTYVQLPG-AYSPLYSPSVASLCSSYEPPPPPPLRPRPMVS 1288

  Fly  1163 AAAAGAGS---------------SSSSMFARSRSDDNILNSLDLLPKGKR-LPPPPPPPYVNRR- 1210
            :.|: |||               .|.::|||||||||||||::..||.:| .||||||||.:::
Mosquito  1289 SKAS-AGSMQPNGGAHLSMASAGPSPALFARSRSDDNILNSVESTPKIRRHPPPPPPPPYESKKA 1352

  Fly  1211 LKKPPMPAPS------EKPP---PIPSKPIPSRMSP-IPPRKPPTLNPHHANSPLTKTSSGAQWA 1265
            ::|||:|.|:      .|||   |.||:|:....:| .||..|....|...:.|..|..:..
Mosquito  1353 IRKPPLPLPTPMEKLIPKPPMAVPSPSQPVVPAFNPERPPEVPAKPTPPKPSGPSAKLQAQI--- 1414

  Fly  1266 GERPRPDLGLGLGLNRGNNSILAQLQASMVAQSHAQAQAQALDIALLREKSKHLDLPLISALCND 1330
             ::..||..|             ...||||.|..|.... ::||..||||||||||||||||.:|
Mosquito  1415 -KKQYPDFDL-------------STVASMVDQQPANDHT-SIDIKTLREKSKHLDLPLISALMHD 1464

  Fly  1331 RSLLKQTKVVINPKTGQ-----------------------------EMPTSS-AQPSGATTNGVA 1365
            |||||||:..:.||..:                             |:|||: ..|.|:|.:..:
Mosquito  1465 RSLLKQTRAFVMPKHPKANASNGLPKGSGGGSGVSGPAGGTAPHNGEVPTSNGGSPPGSTPSPKS 1529

  Fly  1366 N---SSAGAGTLSKARKGSTVSHRHPQDKLPPLPVQ-------QLAEANNYVIDP 1410
            .   |......|:|.|| ::.|||||.|||||||.|       ..||.||||:||
Mosquito  1530 KYPVSGLSTTQLAKPRK-TSASHRHPNDKLPPLPGQTGPGQTGPTAEGNNYVMDP 1583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	90/102 (88%)
		B41	27..297	CDD:214604	165/338 (49%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	59/107 (55%)
		PHA03255	512..>681	CDD:165513	98/204 (48%)
ex	XP_061518329.1	None