DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ex and FRMD6

DIOPT Version :9

Sequence 1:NP_001259823.1 Gene:ex / 33218 FlyBaseID:FBgn0004583 Length:1427 Species:Drosophila melanogaster
Sequence 2:NP_001253975.1 Gene:FRMD6 / 122786 HGNCID:19839 Length:622 Species:Homo sapiens


Alignment Length:681 Identity:153/681 - (22%)
Similarity:249/681 - (36%) Gaps:204/681 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 KTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSS 103
            ::|..:::.|....::..|.|   ....:.|..||||:|:.:.|:::.:...||.||.||.|:..
Human    26 ESLNIIINVKILCHQLLVQVC---DLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKE 87

  Fly   104 H--------THGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAE 160
            .        |.|:|..|.|:: :|||||:|:|:..::.|..:|:.||..||..:|.......  |
Human    88 ASKVRQYEVTWGIDQFGPPMI-IHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLR--E 149

  Fly   161 QALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPK--ISKRANERMLR 223
            :|...||..|||||||       |.|.:         .:.|:........|.  :|||       
Human   150 EAYFLLAAFALQADLG-------NFKRN---------KHYGKYFEPEAYFPSWVVSKR------- 191

  Fly   224 LSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRACHREHLGMATAEAELL 288
                                   |.||  |..::|:             .|::...:..:||.|.
Human   192 -----------------------GKDY--ILKHIPN-------------MHKDQFALTASEAHLK 218

  Fly   289 YIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETT-TFLWPNI 352
            ||::|..| :.:..|.||:...|.|. ..|....:..:||:|.    .|.....:.. .|.|.|:
Human   219 YIKEAVRL-DDVAVHYYRLYKDKREI-EASLTLGLTMRGIQIF----QNLDEEKQLLYDFPWTNV 277

  Fly   353 TKLSFERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKREEEEA 413
            .||.|..|||||    .....::..|.....:::.||.|..::|:..|.|...|:.:.|.||.| 
Human   278 GKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENE- 341

  Fly   414 AESQRLHASY----------------ACSRSLLLPYKSKNEQRISVISSTSSNT----------- 451
             |.::...||                ..|.|.....|.|...|.|..|.:||:|           
Human   342 -EKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRD 405

  Fly   452 -----------------------------TSGIVS---DRVH---SEDELEIMINTPPAPLAAPS 481
                                         |||:.|   ||:.   .:||:|:::: .|..|...:
Human   406 TGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVD-DPRDLEQMN 469

  Fly   482 TESLALA-----HLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRN 541
            .|||.::     ::.:...:||:.:....:.:|::          ....||:..|:|.......:
Human   470 EESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEI----------GSSTSSSSETVVKLRGQSTD 524

  Fly   542 SM-GTTANDSSTATDSPSSQHN-----------IGSQCSST------------------CSTVVV 576
            |: .|......|:||..|...:           |...|..|                  |::.:.
Human   525 SLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLA 589

  Fly   577 TSPVNGAGASSSGAPIPVHSTSSSLELGFSH 607
            ...:|...|      .||..||....|..:|
Human   590 QQCINIQDA------FPVKRTSKYFSLDLTH 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
exNP_001259823.1 B41 27..297 CDD:214604 67/267 (25%)
FERM_N 40..98 CDD:286467 15/57 (26%)
FERM_M 132..305 CDD:278785 39/174 (22%)
FERM_C_FRMD1_FRMD6 298..405 CDD:270006 29/111 (26%)
PHA03255 512..>681 CDD:165513 22/126 (17%)
FRMD6NP_001253975.1 FERM_F1_FRMD6 15..120 CDD:340718 30/97 (31%)
FERM_B-lobe 128..226 CDD:271216 36/160 (23%)
FERM_C_FRMD1_FRMD6 227..335 CDD:270006 29/112 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..445 14/80 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4371
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171513at33208
OrthoFinder 1 1.000 - - FOG0004598
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4456
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

Return to query results.
Submit another query.