Protein Alignment BBS8 and CDC27

DIOPT Version :9

• Sequence 1: NP_608524.1
• Gene: BBS8 / 33217
• FlyBaseID: FBgn0031255
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_009469.2
• Gene: CDC27 / 852194
• SGDID: S000000180
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 457
• Identity: 80/457 - (17%)
• Similarity: 140/457 - (30%)
• Gaps: 135/457 - (29%)

  Fly   181 GRLNSSRPGSAAVARPGTSLS----RPGSSLGSRCGTASRIRATSAAAFNVGDATSKLYQASRLN 241
            |:.::|...:||.:.|.||||    |...||.|        :.......|:.:..:.|:|:|...
Yeast   212 GKKSNSHNNNAASSFPSTSLSHFEPRSQPSLYS--------KTNKNGNNNINNNVNTLFQSSNSP 268

  Fly   242 PTIYAERETLVKALFQFLYYHEADVQKAHSLCQAVLEVERQKP-----SGSTGCTLSWWWQQQMG 301
            |:      |...:.....::..:..|:|::..:.......|.|     :..|...|.       .
Yeast   269 PS------TSASSFSSIQHFSRSQQQQANTSIRTCQNKNTQTPKNPAINSKTSSALP-------N 320

  Fly   302 RCLLALHYPRRAEPFLQQ----------------------------------------------- 319
            ...:.|..|...:|.:..
Yeast   321 NISMNLVSPSSKQPTISSLAKVYNRNKLLTTPPSKLLNNDRNHQNNNNNNNNNNNNNNNNNNNNN 385

  Fly   320 -----SLTSFPHP-DTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAM---- 374
                 :.|:|..| :.|....|:....|.| |:|::...::.|   |.:..|.:...:.|:
Yeast   386 NNNIINKTTFKTPRNLYSSTGRLTTSKKNP-RSLIISNSILTS---DYSITLPEIMYNFALILRS 446

  Fly   375 EQQEDALQLYRLAAKLHPINVES-----LASIAVGYFYDNNPEMALMYYRRILSLG--------- 425
            ..|.::.:..||.....|.:::.     |..:...:|...|.:|:|.|:.|:..|.
Yeast   447 SSQYNSFKAIRLFESQIPSHIKDTMPWCLVQLGKLHFEIINYDMSLKYFNRLKDLQPARVKDMEI 511

  Fly   426 -------------------------AQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQK 465
                                     ...||.:|.|..........|..:..|::    |||....
Yeast   512 FSTLLWHLHDKVKSSNLANGLMDTMPNKPETWCCIGNLLSLQKDHDAAIKAFEK----ATQLDPN 572

  Fly   466 SDIWYNLSFVAVTSGD-FNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDV 529
            ....|.|.....:|.| .:.||.|.:..|..|.|:..|...|...|.:.|....|..|...|:.:
Yeast   573 FAYAYTLQGHEHSSNDSSDSAKTCYRKALACDPQHYNAYYGLGTSAMKLGQYEEALLYFEKARSI 637

  Fly   530 MP 531
            .|
Yeast   638 NP 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TPR repeat	299..322	CDD:276809	3/74 (4%)
		TPR repeat	327..355	CDD:276809	7/28 (25%)
		TPR_16	331..392	CDD:290168	12/64 (19%)
		TPR repeat	365..389	CDD:276809	5/27 (19%)
		Coatomer_WDAD	<378..519	CDD:281977	34/180 (19%)
		TPR_11	394..457	CDD:290150	14/101 (14%)
		TPR repeat	394..424	CDD:276809	7/34 (21%)
		TPR repeat	429..457	CDD:276809	6/27 (22%)
		TPR_11	465..526	CDD:290150	16/61 (26%)
		TPR repeat	466..493	CDD:276809	7/27 (26%)
		TPR repeat	500..526	CDD:276809	6/25 (24%)
CDC27	NP_009469.2	ANAPC3	39..126	CDD:403946
		TPR repeat	434..466	CDD:276809	5/31 (16%)
		TPR repeat	472..500	CDD:276809	7/27 (26%)
		PEP_TPR_lipo	<500..>741	CDD:274350	28/144 (19%)
		TPR repeat	540..568	CDD:276809	7/31 (23%)
		TPR repeat	573..603	CDD:276809	8/29 (28%)
		TPR repeat	608..634	CDD:276809	6/25 (24%)
		TPR repeat	642..668	CDD:276809
		TPR repeat	676..704	CDD:276809
		TPR repeat	710..737	CDD:276809

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3477
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950