DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS8 and ttc8

DIOPT Version :9

Sequence 1:	NP_608524.1	Gene:	BBS8 / 33217	FlyBaseID:	FBgn0031255	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_002933244.1	Gene:	ttc8 / 733857	XenbaseID:	XB-GENE-1000122	Length:	505	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	166/540 - (30%)
Similarity:	245/540 - (45%)	Gaps:	96/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RAVSLYRRRSYERCAELCNALLQAGHDGHVQLFTTKEEEEEEQHQQQQAEHSRFGSNLQRIGPRP 79
            :|.|.:|||.:|.|::.|:.:|                 |:|.:.|.
Frog    10 QAWSYFRRRKFELCSQTCSRIL-----------------EQEPYDQV------------------ 39

  Fly    80 RGAAGGGAGAVDSGPSIMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNEATEEVEFERIATA 144
                                      .|.||.||||:.||||::|.|..| .|...::...||..
Frog    40 --------------------------AWSLKTRALTEMVYVDEIDVDQEG-IAEMMLDENAIAQV 77

  Fly   145 ARPGSSIKTAF-----QPRPLTSQRAQQARSRGAGVAHSSDGRLNSSRPGS--AAVARPGT-SLS 201
            ||||:|:|.|.     .|.|......|..|.....|..|:    .|.|||:  .|:..|.| |.:
Frog    78 ARPGTSLKQAVGKKFDGPSPAVRPVTQSGRPISGFVRPST----QSGRPGTMEQAIKTPRTASTA 138

  Fly   202 RPGSSLGS---RCGTASRIRATSAAAFNVGDATSKLYQASRLNPTIYAERETLVKALFQFLYYHE 263
            ||.:|...   |.||||.:........|:          ||||...|.:...|.|.||:::::||
Frog   139 RPITSTSGRYVRLGTASMLTNPDGPFINL----------SRLNLANYVQHPYLAKTLFEYIFHHE 193

  Fly   264 ADVQKAHSLCQAVLEVERQKPSGSTGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPD 328
            .|.:.|..|.....|....|         .|||:.|:|:|...|...|.||...:.:||.....|
Frog   194 NDAKNALELAALATEESNFK---------DWWWKVQLGKCYYRLGLYREAEKQFKSALTQQNMVD 249

  Fly   329 TYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPI 393
            .:|.|.:||.|:.||..||.|..:.:|..|.:|:.....||||:.|.....|.:.|:...|....
Frog   250 IFLYLGKVYIRMDQPLTALTVFKQGLDRFPKEVSILCAVARIHEEMNNMSSATEYYKEVLKQDNT 314

  Fly   394 NVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALAT 458
            |:|::|.|...:||.:.||:||.:|||:|.:|..:.:|:.|:.:||.|..|.|::|..|:|||:.
Frog   315 NIEAIACIGSNHFYTDQPEIALRFYRRLLQMGVYNCQLFNNLGMCCFYAQQYDMILTSFERALSL 379

  Fly   459 ATQPGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYL 523
            |...|..:::||||..|||..||.|||.:|.:|.|:::..:..|.||||||..:...:..|::.|
Frog   380 AENEGDVAEVWYNLGHVAVGIGDLNLAYQCFKLTLSNNNDHAEAYNNLAVLEMRKNHVEQARALL 444

  Fly   524 NAAKDVMPDAAEVTTNLQFM 543
            ..:..:.|...|...|..|:
Frog   445 QTSSSLAPHMYEPHVNFAFL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TPR repeat	299..322	CDD:276809	7/22 (32%)
		TPR repeat	327..355	CDD:276809	11/27 (41%)
		TPR_16	331..392	CDD:290168	21/60 (35%)
		TPR repeat	365..389	CDD:276809	7/23 (30%)
		Coatomer_WDAD	<378..519	CDD:281977	54/140 (39%)
		TPR_11	394..457	CDD:290150	26/62 (42%)
		TPR repeat	394..424	CDD:276809	14/29 (48%)
		TPR repeat	429..457	CDD:276809	11/27 (41%)
		TPR_11	465..526	CDD:290150	24/60 (40%)
		TPR repeat	466..493	CDD:276809	14/26 (54%)
		TPR repeat	500..526	CDD:276809	9/25 (36%)
ttc8	XP_002933244.1	PEP_TPR_lipo	<159..467	CDD:274350	108/325 (33%)
		TPR repeat	220..243	CDD:276809	7/22 (32%)
		TPR repeat	247..277	CDD:276809	11/29 (38%)
		TPR repeat	282..310	CDD:276809	8/27 (30%)
		TPR repeat	315..345	CDD:276809	14/29 (48%)
		TPR repeat	350..378	CDD:276809	11/27 (41%)
		TPR repeat	383..416	CDD:276809	16/32 (50%)
		TPR repeat	421..445	CDD:276809	8/23 (35%)
		TPR repeat	455..480	CDD:276809	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3232
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D315044at33208
OrthoFinder	1	1.000	-	-		FOG0006606
OrthoInspector	1	1.000	-	-		oto103567
Panther	1	1.100	-	-	LDO	PTHR44177
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160