DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS8 and CG5038

DIOPT Version :9

Sequence 1:	NP_608524.1	Gene:	BBS8 / 33217	FlyBaseID:	FBgn0031255	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	56/283 - (19%)
Similarity:	99/283 - (34%)	Gaps:	94/283 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 IYAERETLVK-------ALFQFLYYHEADVQKAHSLCQAVLEVERQKPSGSTGCTLSWWWQQQMG 301
            :.|||...|.       :::.|||::::..:..|                         |:..:
  Fly   366 VIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTH-------------------------WRTAL- 404

  Fly   302 RCLLALHYP-------RRAEPFLQQSLTSFPHPDTYLLLSRVYQRIKQ--PERALLVIGEVVDSR 357
            |.||.|.:.       :||..:|.:              .::::...|  |:.|
  Fly   405 RILLMLLFSVMMVRTRQRATDWLNE--------------EQLFKSALQVCPDNA----------- 444

  Fly   358 PFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEM--ALMYYRR 420
              .|.|.:  ||:...|.....|.|.|..|.:|:| |.|| |.:.:|..|..:.::  |..|.|.
  Fly   445 --KVHYNI--ARLATDMGNNTKAFQHYHRAIELYP-NYES-ALMNLGNLYREHGQLSTAEEYIRL 503

  Fly   421 ILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSDIWYNLSFVAVTSGDFNLA 485
            .|......|..:.|:.:.....|:.|..|..:::||.            |..:|....   :|:.
  Fly   504 ALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALK------------YRANFAVCY---YNMG 553

  Fly   486 KRCLQLCLTSDA----QNGAALN 504
            ...|:....::|    |:..|||
  Fly   554 NLYLEQKRYAEALHHWQHAVALN 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TPR repeat	299..322	CDD:276809	7/29 (24%)
		TPR repeat	327..355	CDD:276809	3/29 (10%)
		TPR_16	331..392	CDD:290168	13/62 (21%)
		TPR repeat	365..389	CDD:276809	7/23 (30%)
		Coatomer_WDAD	<378..519	CDD:281977	32/133 (24%)
		TPR_11	394..457	CDD:290150	16/64 (25%)
		TPR repeat	394..424	CDD:276809	10/31 (32%)
		TPR repeat	429..457	CDD:276809	6/27 (22%)
		TPR_11	465..526	CDD:290150	9/44 (20%)
		TPR repeat	466..493	CDD:276809	4/26 (15%)
		TPR repeat	500..526	CDD:276809	3/5 (60%)
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	38/167 (23%)
		TPR_1	444..477	CDD:278916	12/48 (25%)
		TPR repeat	444..472	CDD:276809	10/42 (24%)
		TPR_17	466..499	CDD:290167	11/34 (32%)
		TPR repeat	480..506	CDD:276809	6/25 (24%)
		TPR repeat	511..541	CDD:276809	7/41 (17%)
		TPR_1	512..545	CDD:278916	8/44 (18%)
		TPR_1	546..577	CDD:278916	7/34 (21%)
		TPR repeat	546..574	CDD:276809	4/30 (13%)
		TPR repeat	580..608	CDD:276809
		TPR repeat	614..642	CDD:276809
		TPR repeat	647..677	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840