Protein Alignment BBS8 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_608524.1
• Gene: BBS8 / 33217
• FlyBaseID: FBgn0031255
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 118/660 - (17%)
• Similarity: 205/660 - (31%)
• Gaps: 214/660 - (32%)

  Fly    15 RAVSLYRRR--------------SYERCAELCNALLQAGHDG--------HVQLFTTKEEEEEEQ 57
            |..||:.||              ::..|.:|.:...:..|.|        |:|...:::...:.:
  Fly   323 RVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRK 387

  Fly    58 HQQQQAEHSRFGSNLQRIGPRPRGAAGGGAGAVDSGPSIMMPTWLMEGVW-QLKMRALTQRVYVD 121
            ......::..|                                   |..: |.:..||..|
  Fly   388 RLANNTKYQAF-----------------------------------EAAYHQQQQEALPCR---- 413

  Fly   122 DLDEDDGGNEATEEVEFERIATAARPGSS---IKTAFQPRPLTSQRAQQARSRGAGVAHSSDGRL 183
                |...|.::..|.......|..|..:   :.:||:     ..|:..:.|.....:.||....
  Fly   414 ----DCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFR-----GSRSSSSCSNSTNSSSSSSSSS 469

  Fly   184 NSSRPGSAAV-----------ARPGTSLSR------------------PGSSLGSRCG--TASRI 217
            :||...|:::           |..|.|.:.                  |.|:|....|  .|.|:
  Fly   470 SSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERL 534

  Fly   218 RATSAAAF--NVGDATSKLYQAS-RLNPTIYAERETLVKALFQFLYYHEADVQKAHSLCQAVLEV 279
            ....:..|  .||...|||...: |....:......|:.|:........||.:...||.::.:.:
  Fly   535 LYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAI 599

  Fly   280 ERQKPSGSTGCTLSWWWQQQMGRCLL------------------ALH-----YPRRAEPFLQQSL 321
            ...|..|:.|..||...:.:..:.:|                  .||     ||...|.| |:::
  Fly   600 NPPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECF-QRAI 663

  Fly   322 TSFPH----------------------------------------------PDTYLLLSRVYQRI 340
            ...|:                                              ...||.|..:|...
  Fly   664 KFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQ 728

  Fly   341 KQPERALLVIGEVVDSRPFDVTYRLEQAR--IHQ-------AMEQQEDALQLYRLAAKLHPINVE 396
            .:.:|||.:..|.:.|.|     .|.|.|  ::|       .::|.::|.:.:|.|.:|.|..|
  Fly   729 GKLQRALAIYREALSSLP-----GLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQV- 787

  Fly   397 SLASIAVGYFYDNNPEMAL---MYYRRILSLGAQSPELYCNIA----------LCCLYGGQIDLV 448
             .|.::.|.....|...|.   |:::|.|.|..:...:|.:.|          ...:|..:...:
  Fly   788 -AAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAEL 851

  Fly   449 LP---CFQRALATATQPGQK---SDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLA 507
            .|   ....|.|||.:...:   :::||..: ||:..||.:.......:.......|.||.:..|
  Fly   852 APNDYTLVVAAATAMRLLDRKVDAEMWYRKA-VALRPGDAHAHTNLGAILHLLGRTNHAAASYKA 915

  Fly   508 VLAAQSGDIL 517
            .|..|.||.:
  Fly   916 ALRLQPGDAI 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TTC8_N	96..215	CDD:411061	26/153 (17%)
		LapB	299..536	CDD:442196	60/316 (19%)
		TPR repeat	299..322	CDD:276809	8/45 (18%)
		TPR repeat	327..355	CDD:276809	8/27 (30%)
		TPR repeat	365..389	CDD:276809	8/32 (25%)
		TPR repeat	394..424	CDD:276809	8/32 (25%)
		TPR repeat	429..457	CDD:276809	5/40 (13%)
		TPR repeat	466..493	CDD:276809	6/26 (23%)
		TPR repeat	500..526	CDD:276809	7/18 (39%)
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	5/19 (26%)
		TPR	597..852	CDD:440225	46/262 (18%)
		TPR repeat	602..630	CDD:276809	6/27 (22%)
		TPR repeat	635..665	CDD:276809	7/30 (23%)
		TPR repeat	670..694	CDD:276809	0/23 (0%)
		TPR repeat	715..743	CDD:276809	8/27 (30%)
		TPR repeat	748..782	CDD:276809	8/33 (24%)
		TPR	780..>933	CDD:440225	33/149 (22%)
		TPR repeat	787..816	CDD:276809	7/30 (23%)
		TPR repeat	822..850	CDD:276809	3/27 (11%)
		TPR repeat	855..885	CDD:276809	7/30 (23%)
		TPR repeat	890..918	CDD:276809	4/27 (15%)