Protein Alignment BBS8 and bbs-8

DIOPT Version :10

• Sequence 1: NP_608524.1
• Gene: BBS8 / 33217
• FlyBaseID: FBgn0031255
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_504711.2
• Gene: bbs-8 / 188904
• WormBaseID: WBGene00000244
• Length: 506
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 139/449 - (30%)
• Similarity: 216/449 - (48%)
• Gaps: 36/449 - (8%)

  Fly   102 LMEGVWQLKMRALTQRVYVDDLDEDDGGNEATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQ 166
            |.:..|.|||:.|:...|||:|:.:|.|...| .::...||..||||:|.     .||.||.:
 Worm    40 LDQATWALKMQCLSDSTYVDELENEDMGLAET-FLDQNVIAPNARPGTSF-----ARPKTSAK-- 96

  Fly   167 QARSRGAGVAHSSDGRLNSSRPGSAAVARPGTSLSRPGSSLGSRCG----TASRIRATSAAAFNV 227
                   ||........|:.||.| .|.||.:|..........|..    ||..:.:|||....:
 Worm    97 -------GVNPILRPTTNAGRPLS-GVVRPQSSFKSGSMDQAVRTARTAKTARAVSSTSARNMRL 153

  Fly   228 GDAT------SKLYQASRLNPTIYAERETLVKALFQFLYYHEADVQKAHSLCQAVLEVERQKPSG 286
            |.|:      .:....:|||...||....:.:.||::::|:..|::.||.:....     .|.:|
 Worm   154 GTASMAAGADGEFVNLARLNIDKYAADPQVNRQLFEYVFYYLNDIRVAHQIAGTA-----SKAAG 213

  Fly   287 STGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQRIKQPERALLVIG 351
            ..    .::|:.|:.:|.|.|...:.|...||.||......:|:.|||:.|.|:.||..||....
 Worm   214 FE----DYYWKNQLAKCYLRLGMLQDATKQLQSSLEQKKLIETFALLSKAYNRVDQPMAALKTYS 274

  Fly   352 EVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALM 416
            ..::..|.:||.....||:.:|:.:.:::::||:........|:|::|.:|..|:|...||:|:.
 Worm   275 AGLEVFPENVTMLTGMARVQEALGEYDESVKLYKRVLDAESNNIEAIACVATTYYYGGKPELAMR 339

  Fly   417 YYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSDIWYNLSFVAVTSGD 481
            ||||||.:|..||||:.||.|||:...|.|..|....||.:|.|. ...:|:|||:..:.|..||
 Worm   340 YYRRILQMGVSSPELFLNIGLCCMAAQQFDFALSSILRAQSTMTD-DVAADVWYNIGQILVDIGD 403

  Fly   482 FNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
            ...|.|..::.|:.|..:..:|.||.:|..:.|.|..|:|..::|....|...|...||
 Worm   404 LVSAARSFRIALSHDPDHSESLVNLGILKHREGKIDEARSLYSSATSKNPYMFEGNYNL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TTC8_N	96..215	CDD:411061	36/116 (31%)
		LapB	299..536	CDD:442196	80/236 (34%)
		TPR repeat	299..322	CDD:276809	8/22 (36%)
		TPR repeat	327..355	CDD:276809	10/27 (37%)
		TPR repeat	365..389	CDD:276809	5/23 (22%)
		TPR repeat	394..424	CDD:276809	15/29 (52%)
		TPR repeat	429..457	CDD:276809	13/27 (48%)
		TPR repeat	466..493	CDD:276809	9/26 (35%)
		TPR repeat	500..526	CDD:276809	8/25 (32%)
bbs-8	NP_504711.2	TTC8_N	34..171	CDD:411061	42/146 (29%)
		TadD	168..314	CDD:444034	41/154 (27%)
		TPR repeat	221..245	CDD:276809	8/23 (35%)
		TPR repeat	250..278	CDD:276809	10/27 (37%)
		LapB	264..490	CDD:442196	68/200 (34%)
		TPR repeat	287..312	CDD:276809	5/24 (21%)
		TPR repeat	317..347	CDD:276809	15/29 (52%)
		TPR repeat	352..380	CDD:276809	13/27 (48%)
		TPR repeat	388..416	CDD:276809	9/27 (33%)
		TPR repeat	421..451	CDD:276809	9/29 (31%)
		TPR repeat	456..484	CDD:276809	3/7 (43%)