Protein Alignment BBS8 and TTC8

DIOPT Version :10

• Sequence 1: NP_608524.1
• Gene: BBS8 / 33217
• FlyBaseID: FBgn0031255
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001275710.1
• Gene: TTC8 / 123016
• HGNCID: 20087
• Length: 531
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 168/559 - (30%)
• Similarity: 249/559 - (44%)
• Gaps: 126/559 - (22%)

  Fly    16 AVSLYRRRSYERCAELCNALLQAGHDGHVQLFTTKEEEEEEQHQQQQAEHSRFGSNLQRIGPRPR 80
            |.|.:|||.::.||:||..:|                 |:..:.|
Human    11 AWSYFRRRKFQLCADLCTQML-----------------EKSPYDQ-------------------- 38

  Fly    81 GAAGGGAGAVDSGPSIMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNEATEEVEFERIATAA 145
                                    ..|.||.||||:.||:|::|.|..| .|...::...||...
Human    39 ------------------------AAWILKARALTEMVYIDEIDVDQEG-IAEMMLDENAIAQVP 78

  Fly   146 RPGSSIK---------TAFQPRPLTSQRAQQARSRGAGVAHSSDGRLNSSRPGS--AAVARPGTS 199
            |||:|:|         .:...||:|     ||.....|....|   ..|.|||:  .|:..|.|:
Human    79 RPGTSLKLPGTNQTGGPSQAVRPIT-----QAGRPITGFLRPS---TQSGRPGTMEQAIRTPRTA 135

  Fly   200 -LSRP-GSSLGS--RCGTASRIRATSAAAFNVGDATSKLYQASRLNPTIYAERETLVKALFQFLY 260
             .:|| .||.|.  |.||||.:.:......|:          ||||.|.|:::..|.||||::::
Human   136 YTARPITSSSGRFVRLGTASMLTSPDGPFINL----------SRLNLTKYSQKPKLAKALFEYIF 190

  Fly   261 YHEADVQKAH------------------------SLCQAVLEVERQKPSGSTGCTLSWWWQQQMG 301
            :||.||:..|                        :|..|.|..|..:..       .|||:.|:|
Human   191 HHENDVKTIHLEDVVLHLGIYPFLLRNKNHIEKNALDLAALSTEHSQYK-------DWWWKVQIG 248

  Fly   302 RCLLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLE 366
            :|...|...|.||...:.:|......||:|.|::||..:.||..||.:..:.:|..|.:||....
Human   249 KCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCG 313

  Fly   367 QARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPEL 431
            .|||::.|.....|.:.|:...|....:||::|.|...:||.:.||:||.:|||:|.:|..:.:|
Human   314 IARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQL 378

  Fly   432 YCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSD 496
            :.|:.|||.|..|.|:.|..|:|||:.|....:.:|:||||..|||..||.|||.:|.:|.|.::
Human   379 FNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNN 443

  Fly   497 AQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAE 535
            ..:..|.||||||..:.|.:..|::.|..|..:.|...|
Human   444 NNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYE 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS8	NP_608524.1	TTC8_N	96..215	CDD:411061	43/133 (32%)
		LapB	299..536	CDD:442196	87/237 (37%)
		TPR repeat	299..322	CDD:276809	7/22 (32%)
		TPR repeat	327..355	CDD:276809	10/27 (37%)
		TPR repeat	365..389	CDD:276809	6/23 (26%)
		TPR repeat	394..424	CDD:276809	14/29 (48%)
		TPR repeat	429..457	CDD:276809	12/27 (44%)
		TPR repeat	466..493	CDD:276809	15/26 (58%)
		TPR repeat	500..526	CDD:276809	10/25 (40%)
TTC8	NP_001275710.1	TTC8_N	30..169	CDD:411061	49/218 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..127		6/21 (29%)
		TPR 2	241..274		11/32 (34%)
		TPR repeat	246..269	CDD:276809	7/22 (32%)
		LapB	248..527	CDD:442196	86/235 (37%)
		TPR repeat	273..303	CDD:276809	10/29 (34%)
		TPR 3	275..307		12/31 (39%)
		TPR 4	308..341		9/32 (28%)
		TPR repeat	308..336	CDD:276809	8/27 (30%)
		TPR 5	342..375		15/32 (47%)
		TPR repeat	342..370	CDD:276809	13/27 (48%)
		TPR 6	376..409		14/32 (44%)
		TPR repeat	377..404	CDD:276809	12/26 (46%)
		TPR repeat	409..442	CDD:276809	16/32 (50%)
		TPR 7	413..446		16/32 (50%)
		TPR 8	447..480		12/32 (38%)
		TPR repeat	447..473	CDD:276809	10/25 (40%)
		TPR repeat	481..506	CDD:276809	1/2 (50%)