DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebi and HOS15

DIOPT Version :9

Sequence 1:	NP_477329.1	Gene:	ebi / 33212	FlyBaseID:	FBgn0263933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_201533.1	Gene:	HOS15 / 836867	AraportID:	AT5G67320	Length:	613	Species:	Arabidopsis thaliana

Alignment Length:	736	Identity:	278/736 - (37%)
Similarity:	370/736 - (50%)	Gaps:	165/736 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWS- 65
            |.:|.|:||||:||||||||.|:|:..|.|:.|::|||:|.:|||.||:..:||||.|.|:|.:
plant     3 SLTSVELNFLVFRYLQESGFTHAAFTLGYEAGINKSNIDGNMVPPGALIKFVQKGLQYMEMEANL 67

  Fly    66 ------VGEDGEVARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEI 124
                  :.||....:|      :|.:..:||.|:.:::.:..|...::       .:.:.:|
plant    68 SNSEVDIDEDFSFFQP------LDLISKDVKELQDMLREKKRKERDME-------KERDRSK--- 116

  Fly   125 KIEPGTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGS 189
              |...||.....|::             ..|.|.|..
plant   117 --ENDKGVEREHEGDR-------------NRAKEKDRH--------------------------- 139

  Fly   190 NSTSTPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTN------------ 242
                           ..||:.:...|.................:.........
plant   140 ---------------EKQKEREREREKLEREKEREREKIEREKEREREKMEREIFEREKDRLKLE 189

  Fly   243 -----GNSSTSSSVEQPTS---GLTPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQG 299
                 ........:|:..|   .|..|...:.....|...:|..||               ||:
plant   190 KEREIEREREREKIEREKSHEKQLGDADREMVIDQTDKEIAGDGST---------------GAE- 238

  Fly   300 NNVQSGSSNAQSSAPSGTISSSTSGGAGTPAALVPMDI-----DENIEIPESKARVLRGHESEVF 359
                                              ||||     .:...||.|..|:|.||.|||.
plant   239 ----------------------------------PMDIVMTPTSQTSHIPNSDVRILEGHTSEVC 269

  Fly   360 ICAWNPSRDLLASGSGDSTARIWDMSDAN-------TNSNQLVLRHCIQKGGAEVPSNKDVTSLD 417
            .|||:||..||||||||:|||||.:.:.:       .|.|.|:|:|.  ||.:...| ||||:||
plant   270 ACAWSPSASLLASGSGDATARIWSIPEGSFKAVHTGRNINALILKHA--KGKSNEKS-KDVTTLD 331

  Fly   418 WNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKGPIFALKWNKCGNYILSAGVDKTTIIWDAST 482
            ||.:|:||||||.||.||||..:|.|.|||.:||||||:|||||.|:|:|:..||:|.::||...
plant   332 WNGEGTLLATGSCDGQARIWTLNGELISTLSKHKGPIFSLKWNKKGDYLLTGSVDRTAVVWDVKA 396

  Fly   483 GQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIHVCRLGVNEPIKTFKGHTNEVNAIKWCPQGQ 547
            .:..|||.|||.|.|||||:.|.:||:.|||..|::|::|...|.|||.||..|||.:||.|.|.
plant   397 EEWKQQFEFHSGPTLDVDWRNNVSFATSSTDSMIYLCKIGETRPAKTFTGHQGEVNCVKWDPTGS 461

  Fly   548 LLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTIKWSPTGPGTNNPNTNLILASASFDSTVRLW 612
            ||||||||.|.|||::.:....|||:.|:||||||:||||||||||||..|.||||||||||:||
plant   462 LLASCSDDSTAKIWNIKQSTFVHDLREHTKEIYTIRWSPTGPGTNNPNKQLTLASASFDSTVKLW 526

  Fly   613 DVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSFDKCVHIWSTQTGQLVHSYKGTGGIFEVCWN 677
            |.|.|..:.:...|.|||||:||||:|:::||||.||.:||||.:.|::|.:|.|.|||||||||
plant   527 DAELGKMLCSFNGHREPVYSLAFSPNGEYIASGSLDKSIHIWSIKEGKIVKTYTGNGGIFEVCWN 591

  Fly   678 SKGTKVGASASDGSVFVLDLR 698
            .:|.|:.|..:|.||.|||.|
plant   592 KEGNKIAACFADNSVCVLDFR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebi	NP_477329.1	LisH	6..32	CDD:285685	16/25 (64%)
		WD40	349..655	CDD:238121	181/312 (58%)
		WD40 repeat	358..402	CDD:293791	24/50 (48%)
		WD40 repeat	414..449	CDD:293791	23/34 (68%)
		WD40 repeat	454..490	CDD:293791	17/35 (49%)
		eIF2A	457..665	CDD:285825	120/207 (58%)
		WD40 repeat	497..531	CDD:293791	17/33 (52%)
		WD40 repeat	537..573	CDD:293791	20/35 (57%)
		WD40 repeat	579..624	CDD:293791	32/44 (73%)
		WD40 repeat	630..654	CDD:293791	15/23 (65%)
HOS15	NP_201533.1	LisH	8..32	CDD:369916	16/23 (70%)
		WD40	258..569	CDD:238121	181/313 (58%)
		WD40 repeat	269..313	CDD:293791	21/43 (49%)
		WD40 repeat	327..363	CDD:293791	24/35 (69%)
		WD40 repeat	369..405	CDD:293791	17/35 (49%)
		WD40 repeat	410..445	CDD:293791	17/34 (50%)
		WD40 repeat	452..487	CDD:293791	19/34 (56%)
		WD40 repeat	493..538	CDD:293791	32/44 (73%)
		WD40 repeat	544..580	CDD:293791	20/35 (57%)
		WD40 repeat	585..608	CDD:293791	13/22 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	54	1.000	Domainoid score	I4173
eggNOG	1	0.900	-	-		E2759_KOG0273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I282
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1463197at2759
OrthoFinder	1	1.000	-	-		FOG0002050
OrthoInspector	1	1.000	-	-		oto3804
orthoMCL	1	0.900	-	-		OOG6_102387
Panther	1	1.100	-	-	O	PTHR22846
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840