DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebi and Tbl1xr1

DIOPT Version :9

Sequence 1:	NP_477329.1	Gene:	ebi / 33212	FlyBaseID:	FBgn0263933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_109657.2	Gene:	Tbl1xr1 / 81004	MGIID:	2441730	Length:	514	Species:	Mus musculus

Alignment Length:	702	Identity:	386/702 - (54%)
Similarity:	435/702 - (61%)	Gaps:	191/702 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWS 65
            ||.||||||||||||||||||.|||:.||||||||||||||||||||||::|:||||.|.|.|.|
Mouse     1 MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVS 65

  Fly    66 VGEDGEV--ARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEP 128
            :.|||.:  .||||.|||||||||:|      |:|..
Mouse    66 INEDGTLFDGRPIESLSLIDAVMPDV------VQTRQ---------------------------- 96

  Fly   129 GTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTS 193
                  .|..:|:|          .|.|:...::..|.|..|....|.|.|.|.:
Mouse    97 ------QAYRDKLA----------QQHAAAAAAAAAATNQQGSAKNGENTANGEE---------- 135

  Fly   194 TPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGL 258
                                                            ||
Mouse   136 ------------------------------------------------NG--------------- 137

  Fly   259 TPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTS 323
               ..|::.::.|.
Mouse   138 ---AHTIANNHTDM--------------------------------------------------- 148

  Fly   324 GGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDMSDAN 388
                       |::|.::|||.:||.||||||||||||||||..|||||||||||||||::|:.:
Mouse   149 -----------MEVDGDVEIPSNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENS 202

  Fly   389 TNS-NQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKG 452
            |:. .||||||||::||.:|||||||||||||.:|:|||||||||:||||..||.||||||||||
Mouse   203 TSGPTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKG 267

  Fly   453 PIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIH 517
            |||||||||.||:|||||||||||||||.||:..|||.||||||||||||:|..|||||||..||
Mouse   268 PIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIH 332

  Fly   518 VCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTI 582
            ||:||.:.|||||:|||||||||||.|.|.||||||||||||||||.:|.|.||||||:||||||
Mouse   333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTI 397

  Fly   583 KWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSF 647
            |||||||||||||.||:|||||||||||||||:||.||||||||.||||||||||||::||||||
Mouse   398 KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSF 462

  Fly   648 DKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRK 699
            |||||||:||||.|||||:|||||||||||:.|.|||||||||||.||||||
Mouse   463 DKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebi	NP_477329.1	LisH	6..32	CDD:285685	22/25 (88%)
		WD40	349..655	CDD:238121	251/306 (82%)
		WD40 repeat	358..402	CDD:293791	33/44 (75%)
		WD40 repeat	414..449	CDD:293791	27/34 (79%)
		WD40 repeat	454..490	CDD:293791	29/35 (83%)
		eIF2A	457..665	CDD:285825	173/207 (84%)
		WD40 repeat	497..531	CDD:293791	24/33 (73%)
		WD40 repeat	537..573	CDD:293791	28/35 (80%)
		WD40 repeat	579..624	CDD:293791	40/44 (91%)
		WD40 repeat	630..654	CDD:293791	21/23 (91%)
Tbl1xr1	NP_109657.2	LisH	7..31	CDD:369916	20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..139		9/100 (9%)
		WD40	164..470	CDD:238121	251/305 (82%)
		WD 1	167..206		30/38 (79%)
		WD40 repeat	172..215	CDD:293791	31/42 (74%)
		WD 2	223..262		31/38 (82%)
		WD40 repeat	228..264	CDD:293791	28/35 (80%)
		WD 3	264..303		32/38 (84%)
		WD40 repeat	270..306	CDD:293791	29/35 (83%)
		WD 4	306..344		28/37 (76%)
		WD40 repeat	311..346	CDD:293791	25/34 (74%)
		WD 5	347..386		31/38 (82%)
		WD40 repeat	353..388	CDD:293791	27/34 (79%)
		WD 6	389..437		42/47 (89%)
		WD40 repeat	394..439	CDD:293791	40/44 (91%)
		TolB	<436..>514	CDD:392172	67/77 (87%)
		WD 7	440..479		33/38 (87%)
		WD40 repeat	445..483	CDD:293791	32/37 (86%)
		WD 8	481..513		26/31 (84%)
		WD40 repeat	486..509	CDD:293791	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833495
Domainoid	1	1.000	81	1.000	Domainoid score	I8487
eggNOG	1	0.900	-	-		E2759_KOG0273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I786
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S2019
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002050
OrthoInspector	1	1.000	-	-		otm42983
orthoMCL	1	0.900	-	-		OOG6_102387
Panther	1	1.100	-	-	O	PTHR22846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R560
SonicParanoid	1	1.000	-	-		X1519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740