DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ebi and TBL1X

DIOPT Version :9

Sequence 1:NP_477329.1 Gene:ebi / 33212 FlyBaseID:FBgn0263933 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_001132938.1 Gene:TBL1X / 6907 HGNCID:11585 Length:577 Species:Homo sapiens


Alignment Length:702 Identity:387/702 - (55%)
Similarity:440/702 - (62%) Gaps:179/702 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWS 65
            ||.:|||||||||||||||||.|||:.||||||||||||||.|||||||::||||||.|.|.|.|
Human    52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEIS 116

  Fly    66 VGEDGEV--ARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEP 128
            :.|||.|  .||||.|||||||||:|                                       
Human   117 INEDGTVFDGRPIESLSLIDAVMPDV--------------------------------------- 142

  Fly   129 GTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTS 193
                                                                             
Human   143 ----------------------------------------------------------------- 142

  Fly   194 TPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGL 258
                        .|.:.|...|..:....:|..|.|.:|..|.::|:|:                
Human   143 ------------VQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTS---------------- 179

  Fly   259 TPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTS 323
              ||  ||..||   :....:|..|.:              |...|.:::|:             
Human   180 --AG--VSHQNP---SKNREATVNGEE--------------NRAHSVNNHAK------------- 210

  Fly   324 GGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDMSD-A 387
                      ||:||..:|||.|||.||||||||||||||||..|||||||||||||||:::: :
Human   211 ----------PMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 265

  Fly   388 NTNSNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKG 452
            |..|.||||||||::||.:|||||||||||||.:|:|||||||||:||||..||.||||||||||
Human   266 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKG 330

  Fly   453 PIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIH 517
            ||||||||:.||||||||||||||||||.||:..|||.||||||||||||.|..|||||||..||
Human   331 PIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 395

  Fly   518 VCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTI 582
            |||||.:.|:|||:|||||||||||.|.|.||||||||||||||||.::.|.||||||:||||||
Human   396 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTI 460

  Fly   583 KWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSF 647
            |||||||.|:|||:|::||||||||||||||:|||.|.||||||.|||||||||||||:||||||
Human   461 KWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525

  Fly   648 DKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRK 699
            |||||||:||:|.|||||:|||||||||||::|.|||||||||||.||||||
Human   526 DKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ebiNP_477329.1 LisH 6..32 CDD:285685 22/25 (88%)
WD40 349..655 CDD:238121 247/306 (81%)
WD40 repeat 358..402 CDD:293791 33/44 (75%)
WD40 repeat 414..449 CDD:293791 27/34 (79%)
WD40 repeat 454..490 CDD:293791 29/35 (83%)
eIF2A 457..665 CDD:285825 168/207 (81%)
WD40 repeat 497..531 CDD:293791 24/33 (73%)
WD40 repeat 537..573 CDD:293791 27/35 (77%)
WD40 repeat 579..624 CDD:293791 36/44 (82%)
WD40 repeat 630..654 CDD:293791 22/23 (96%)
TBL1XNP_001132938.1 LisH 57..83 CDD:285685 22/25 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..202 10/61 (16%)
WD40 215..577 CDD:225201 290/361 (80%)
WD40 227..533 CDD:238121 247/305 (81%)
WD 1 230..269 29/38 (76%)
WD40 repeat 235..282 CDD:293791 33/46 (72%)
WD 2 286..325 31/38 (82%)
WD40 repeat 292..327 CDD:293791 27/34 (79%)
WD 3 327..366 32/38 (84%)
WD40 repeat 332..368 CDD:293791 29/35 (83%)
WD 4 369..409 30/39 (77%)
WD40 repeat 375..409 CDD:293791 24/33 (73%)
WD 5 410..449 30/38 (79%)
WD40 repeat 415..451 CDD:293791 27/35 (77%)
WD 6 452..500 38/47 (81%)
WD40 repeat 457..502 CDD:293791 36/44 (82%)
WD 7 503..542 33/38 (87%)
WD40 repeat 508..532 CDD:293791 22/23 (96%)
WD 8 544..576 26/31 (84%)
WD40 repeat 549..572 CDD:293791 19/22 (86%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143321
Domainoid 1 1.000 114 1.000 Domainoid score I6071
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4128
Inparanoid 1 1.050 635 1.000 Inparanoid score I832
Isobase 1 0.950 - 0.993157 Normalized mean entropy S2019
OMA 1 1.010 - - QHG53955
OrthoDB 1 1.010 - - D1463197at2759
OrthoFinder 1 1.000 - - FOG0002050
OrthoInspector 1 1.000 - - otm40910
orthoMCL 1 0.900 - - OOG6_102387
Panther 1 1.100 - - LDO PTHR22846
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R560
SonicParanoid 1 1.000 - - X1519
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.850

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