DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebi and tbl1xr1

DIOPT Version :9

Sequence 1:	NP_477329.1	Gene:	ebi / 33212	FlyBaseID:	FBgn0263933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001017274.1	Gene:	tbl1xr1 / 550028	XenbaseID:	XB-GENE-482046	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	702	Identity:	393/702 - (55%)
Similarity:	440/702 - (62%)	Gaps:	181/702 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWS 65
            ||.||||||||||||||||||.|||:.||||||||||||||||||||||::|:||||.|.|.|.|
Frog     1 MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVS 65

  Fly    66 VGEDGEV--ARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEP 128
            :.|||.:  .||||.|||||||||:|
Frog    66 INEDGTLFDGRPIESLSLIDAVMPDV--------------------------------------- 91

  Fly   129 GTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTS 193
                                 ..|.|.|..
Frog    92 ---------------------VQTRQQAYR----------------------------------- 100

  Fly   194 TPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGL 258
                         .|.:|....|.::::..|..|       ||::||.|         :||
Frog   101 -------------DKLAQQQAAAAAAAAAAAAAA-------AAAATSNN---------QQP---- 132

  Fly   259 TPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTS 323
                          .|..|.:||.|.:....|:       .||...
Frog   133 --------------PAKNGENTANGEENGGHAL-------ANNHTD------------------- 157

  Fly   324 GGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDMSDAN 388
                      .|::|.::|||.|||.||||||||||||||||..|||||||||||||||::|:.:
Frog   158 ----------MMEVDGDVEIPSSKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENS 212

  Fly   389 TN-SNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKG 452
            |: |.||||||||::||.:|||||||||||||.:|:|||||||||:||||..||.||||||||||
Frog   213 TSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKG 277

  Fly   453 PIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIH 517
            |||||||||.||:|||||||||||||||.||:..|||.||||||||||||:|..|||||||..||
Frog   278 PIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIH 342

  Fly   518 VCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTI 582
            ||:||.:.|||||:|||||||||||.|.|.||||||||||||||||..|.|.||||||:||||||
Frog   343 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKHDTCVHDLQAHNKEIYTI 407

  Fly   583 KWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSF 647
            |||||||||||||.||:|||||||||||||||:||.||||||||.||||||||||||::||||||
Frog   408 KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSF 472

  Fly   648 DKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRK 699
            |||||||:||||.|||||:|||||||||||:.|.|||||||||||.||||||
Frog   473 DKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebi	NP_477329.1	LisH	6..32	CDD:285685	22/25 (88%)
		WD40	349..655	CDD:238121	252/306 (82%)
		WD40 repeat	358..402	CDD:293791	34/44 (77%)
		WD40 repeat	414..449	CDD:293791	27/34 (79%)
		WD40 repeat	454..490	CDD:293791	29/35 (83%)
		eIF2A	457..665	CDD:285825	173/207 (84%)
		WD40 repeat	497..531	CDD:293791	24/33 (73%)
		WD40 repeat	537..573	CDD:293791	28/35 (80%)
		WD40 repeat	579..624	CDD:293791	40/44 (91%)
		WD40 repeat	630..654	CDD:293791	21/23 (91%)
tbl1xr1	NP_001017274.1	LisH	7..31	CDD:369916	20/23 (87%)
		WD40	174..480	CDD:238121	252/305 (83%)
		WD40 repeat	182..225	CDD:293791	32/42 (76%)
		WD40 repeat	239..274	CDD:293791	27/34 (79%)
		WD40 repeat	279..315	CDD:293791	29/35 (83%)
		WD40 repeat	322..356	CDD:293791	24/33 (73%)
		WD40 repeat	362..398	CDD:293791	28/35 (80%)
		WD40 repeat	404..449	CDD:293791	40/44 (91%)
		WD40 repeat	455..479	CDD:293791	21/23 (91%)
		WD40 repeat	496..522	CDD:293791	21/25 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8446
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I811
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1463197at2759
OrthoFinder	1	1.000	-	-		FOG0002050
OrthoInspector	1	1.000	-	-		otm48108
Panther	1	1.100	-	-	O	PTHR22846
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1519
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080