DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ebi and tbl1x

DIOPT Version :9

Sequence 1:	NP_477329.1	Gene:	ebi / 33212	FlyBaseID:	FBgn0263933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001120367.1	Gene:	tbl1x / 100145441	XenbaseID:	XB-GENE-982285	Length:	520	Species:	Xenopus tropicalis

Alignment Length:	702	Identity:	395/702 - (56%)
Similarity:	441/702 - (62%)	Gaps:	185/702 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFSSDEVNFLVYRYLQESGFLHSAYVFGIESHISQSNINGALVPPAALLTILQKGLLYTEVEWS 65
            ||.:|||||||||||||||||.|||:.||||||||||||||.|||||||::||||||.|.|.|.|
Frog     1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEIS 65

  Fly    66 VGEDGEV--ARPIEGLSLIDAVMPEVKPLKPIVKTEPGKPGAVDSSAPAGGNQNNNAKPEIKIEP 128
            :.|||.|  .||||.|||||||||:|      |:|..
Frog    66 INEDGTVFDGRPIESLSLIDAVMPDV------VQTRQ---------------------------- 96

  Fly   129 GTGVAGSAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQASTGGSNSTS 193
                  .|...|:|         ..|:||.|
Frog    97 ------QAFREKLA---------QQQAASTV---------------------------------- 112

  Fly   194 TPAGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQPTSGL 258
                   .||.|                       |.:|...||...|..|
Frog   113 -------TAPCA-----------------------APTTPVPASQQGTPKN-------------- 133

  Fly   259 TPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTISSSTS 323
                              ||:|..|.:              |...:.:::|::
Frog   134 ------------------GAATVNGEE--------------NGAHAINNHAEA------------ 154

  Fly   324 GGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARIWDM-SDA 387
                       |:||.::|||.:||.||||||||||||||||..|||||||||||||||:: .::
Frog   155 -----------MEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLIENS 208

  Fly   388 NTNSNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKG 452
            |:||.||||||||::||.:|||||||||||||.||:|||||||||:||||..||.||||||||||
Frog   209 NSNSTQLVLRHCIREGGQDVPSNKDVTSLDWNTDGTLLATGSYDGFARIWTQDGNLASTLGQHKG 273

  Fly   453 PIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCSTDQRIH 517
            |||||||||.||||||||||||||||||.||:..|||.||||||||||||.|..|||||||..||
Frog   274 PIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIH 338

  Fly   518 VCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAHSKEIYTI 582
            |||||.:.|:|||:|||||||||||.|.|..|||||||||||||||..|.|.|||||||||||||
Frog   339 VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMHLASCSDDMTLKIWSMKEDVCVHDLQAHSKEIYTI 403

  Fly   583 KWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSF 647
            |||||||||:|||:|::||||||||||||||||||.||||||||.|||||||||||||:||||||
Frog   404 KWSPTGPGTSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSF 468

  Fly   648 DKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASASDGSVFVLDLRK 699
            |||||||:||:|.|||||:|||||||||||::|.|||||||||||.||||||
Frog   469 DKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ebi	NP_477329.1	LisH	6..32	CDD:285685	22/25 (88%)
		WD40	349..655	CDD:238121	254/306 (83%)
		WD40 repeat	358..402	CDD:293791	34/44 (77%)
		WD40 repeat	414..449	CDD:293791	28/34 (82%)
		WD40 repeat	454..490	CDD:293791	30/35 (86%)
		eIF2A	457..665	CDD:285825	173/207 (84%)
		WD40 repeat	497..531	CDD:293791	24/33 (73%)
		WD40 repeat	537..573	CDD:293791	27/35 (77%)
		WD40 repeat	579..624	CDD:293791	39/44 (89%)
		WD40 repeat	630..654	CDD:293791	22/23 (96%)
tbl1x	NP_001120367.1	LisH	7..31	CDD:369916	20/23 (87%)
		WD40	170..476	CDD:238121	254/305 (83%)
		WD40 repeat	178..221	CDD:293791	32/42 (76%)
		WD40 repeat	235..270	CDD:293791	28/34 (82%)
		WD40 repeat	275..311	CDD:293791	30/35 (86%)
		WD40 repeat	318..352	CDD:293791	24/33 (73%)
		WD40 repeat	358..394	CDD:293791	27/35 (77%)
		WD40 repeat	400..445	CDD:293791	39/44 (89%)
		WD40 repeat	451..475	CDD:293791	22/23 (96%)
		WD40 repeat	492..515	CDD:293791	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8987
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4128
Inparanoid	1	1.050	639	1.000	Inparanoid score	I811
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1463197at2759
OrthoFinder	1	1.000	-	-		FOG0002050
OrthoInspector	1	1.000	-	-		otm48108
Panther	1	1.100	-	-	LDO	PTHR22846
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1519
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160