DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and AP3D1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001248755.1	Gene:	AP3D1 / 8943	HGNCID:	568	Length:	1215	Species:	Homo sapiens

Alignment Length:	652	Identity:	155/652 - (23%)
Similarity:	296/652 - (45%)	Gaps:	111/652 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|::.:..|:.:.|.|...   .|...||||.::.:||:||.:.....:.::|::|::.
Human    29 KEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTF 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |:||||..|...:..:|:|.|....|:.||.|.:.....:||..::...:.|:|...:|:|..|:
Human    91 KRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
Human   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
Human   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
Human   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..||
Human   315 SDQNLKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEI 376

  Fly   418 VQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYVSEEVWYRV 477
            |::::.:::.|: .:.|:|::.|:..:..    :|.|::.||:.:::.|.|:.|......:..::
Human   377 VKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441

  Fly   478 IQIVINREEVQGYAAKTVFEALQ-----APACHEN----MVKVGGYILGEFGNLIAGDSRSAPLV 533
            :.:.|..:.::.:|...:...|.     |.:...|    ::....:|.|||.
Human   442 LDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFS------------- 493

  Fly   534 QFKLLHSKYHLCSPMTR-------ALLLSTYIK-FINLFPEIRTNIQD--------------VFR 576
              :.|...:|....|.|       ..:.:.|:: .:.|:..|....:.              |.|
Human   494 --EHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDR 556

  Fly   577 QHSNLRSADAELQQRASEYLQL----SIVASTDVLATVLEEMPS-FPERESSILAVLKKKKPGRV 636
            ....::|||.|:|:|||..|||    ..:.:.||  .|.||:.: |....:.:....:||.|  |
Human   557 LPQFVQSADLEVQERASCILQLVKHIQKLQAKDV--PVAEEVSALFAGELNPVAPKAQKKVP--V 617

  Fly   637 PE 638
            ||
Human   618 PE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	139/602 (23%)
		Alpha_adaptinC2	730..839	CDD:197886
		Alpha_adaptin_C	839..947	CDD:280460
AP3D1	NP_001248755.1	Adaptin_N	32..581	CDD:279882	141/605 (23%)
		HEAT repeat	151..172	CDD:293787	5/22 (23%)
		Cnd1	155..265	CDD:289487	30/132 (23%)
		HEAT repeat	184..212	CDD:293787	9/30 (30%)
		HEAT repeat	220..262	CDD:293787	9/59 (15%)
		HEAT repeat	271..292	CDD:293787	4/20 (20%)
		HEAT repeat	301..330	CDD:293787	9/28 (32%)
		HEAT repeat	335..364	CDD:293787	8/29 (28%)
		BLVR	661..807	CDD:283923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910