DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and AP3D1

DIOPT Version :10

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_001248755.1 Gene:AP3D1 / 8943 HGNCID:568 Length:1215 Species:Homo sapiens


Alignment Length:652 Identity:155/652 - (23%)
Similarity:296/652 - (45%) Gaps:111/652 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|::.:..|:.:.|.|...   .|...||||.::.:||:||.:.....:.::|::|::.
Human    29 KEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTF 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |:||||..|...:..:|:|.|....|:.||.|.:.....:||..::...:.|:|...:|:|..|:
Human    91 KRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
Human   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
Human   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
Human   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..||
Human   315 SDQNLKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEI 376

  Fly   418 VQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYVSEEVWYRV 477
            |::::.:::.|: .:.|:|::.|:..:..    :|.|::.||:.:::.|.|:.|......:..::
Human   377 VKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQM 441

  Fly   478 IQIVINREEVQGYAAKTVFEALQ-----APACHEN----MVKVGGYILGEFGNLIAGDSRSAPLV 533
            :.:.|..:.::.:|...:...|.     |.:...|    ::....:|.|||.             
Human   442 LDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFS------------- 493

  Fly   534 QFKLLHSKYHLCSPMTR-------ALLLSTYIK-FINLFPEIRTNIQD--------------VFR 576
              :.|...:|....|.|       ..:.:.|:: .:.|:..|....:.              |.|
Human   494 --EHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDR 556

  Fly   577 QHSNLRSADAELQQRASEYLQL----SIVASTDVLATVLEEMPS-FPERESSILAVLKKKKPGRV 636
            ....::|||.|:|:|||..|||    ..:.:.||  .|.||:.: |....:.:....:||.|  |
Human   557 LPQFVQSADLEVQERASCILQLVKHIQKLQAKDV--PVAEEVSALFAGELNPVAPKAQKKVP--V 617

  Fly   637 PE 638
            ||
Human   618 PE 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..603 CDD:396262 141/611 (23%)
Alpha_adaptinC2 730..839 CDD:197886
Alpha_adaptin_C 839..947 CDD:426707
AP3D1NP_001248755.1 Adaptin_N 32..581 CDD:396262 141/605 (23%)
HEAT repeat 151..172 CDD:293787 5/22 (23%)
HEAT repeat 184..212 CDD:293787 9/30 (30%)
HEAT repeat 220..262 CDD:293787 9/59 (15%)
HEAT repeat 271..292 CDD:293787 4/20 (20%)
HEAT repeat 301..330 CDD:293787 9/28 (32%)
HEAT repeat 335..364 CDD:293787 8/29 (28%)
AP3D1 661..807 CDD:461889
Blue background indicates that the domain is not in the aligned region.

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