DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and APL4

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_015354.1	Gene:	APL4 / 856141	SGDID:	S000006233	Length:	832	Species:	Saccharomyces cerevisiae

Alignment Length:	917	Identity:	201/917 - (21%)
Similarity:	388/917 - (42%)	Gaps:	182/917 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GCEVVSPIDQSRGGKESEASADESLLFYCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYV 70
            |..:.|.|...||.|   ..|||..:            |.|:.|.||:|.:.|. |...:::..:
Yeast     2 GSSLRSFIKDVRGAK---TLADERAI------------ITKQSAKIRTKLRDDH-LPHEKRRVNI 50

  Fly    71 CKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRN 135
            .|||::::||....||.:|::||::|:.:.:|::|||..::|::.:.||:.|:...:.|||...|
Yeast    51 QKLLYLYILGEKTHFGQVESINLIASDDFVDKRLGYLAATLLLDESEDLLTLLTNMLNNDLHHPN 115

  Fly   136 PVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVK---QSAA------LCLLRLFRSSP 191
            ...|:|||..:..:.|.::|.....::..::.:.....::|   |.||      :.||.:|.
Yeast   116 KYAVSLALTSLGFLSSPELARDLYPDVENIIKNSRDPFLLKKALQCAAKLIFKDVSLLEIFN--- 177

  Fly   192 DIIPGGEWTSRIIHLLNDQHM---GVVTAATSLIDALV------KRNPDEYKGCV---NLAVSRL 244
                    ...|..:|:...:   ||:...|.:|.:::      |::.||.:..:   |..:|.|
Yeast   178 --------IEDITKILSSHSICTHGVLLGVTKIIQSILLIGLNRKKDEDEDEDGIDYSNDILSPL 234

  Fly   245 SRIVTASYTDLQD---------YTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNETLE--- 297
            |.::...:..|::         |....:..|:|..:::..|:.|..|    |.....|..|:
Yeast   235 SLLLRDFFIRLENMNSKNIEPGYDVQGICDPFLQCEIIYTLKLYFQV----GELLNSNNVLDYKD 295

  Fly   298 ---TILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLRY 359
               .:|.:......|.|    |:..|:|:|.:..|...|....|.|...|.|.:||:.::.|.:|
Yeast   296 NFCDLLTRIATNTDSTK----NSGQAILYETVKTIFSLDLNQPLRVLGINILAKFLAGKDNNTKY 356

  Fly   360 LALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNY 424
            ::|.::..:...|  ...|::|::.:...:: :.|||:|..|::|.:|:.|..|..|:|.|::.:
Yeast   357 VSLNTLLKVVPQE--PTAVQRHRKFISHCLQ-DTDVSIRMRALELSFAILDDSNLVELVNELMKF 418

  Fly   425 LETADYSIREEMVLKVAILAEKYAT----DYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINRE 485
            |...|...::.::..:..|.:.:.|    |.:|.:||..|::::.|.:::.|....::.|:.|..
Yeast   419 LAKQDEDSKDLIIYTIDHLIDTFDTRVVKDESWKLDVFFNILKLVGSFINYEKINDILIIINNTS 483

  Fly   486 EVQG---YAAKTVFEALQAPACHENMVKVGG-----YILGEFGNLI--AGDSRSAPLVQFKLLHS 540
            ::..   :..|.:..:|...:...:...:|.     :.:||:|:|:  .|:...|.::....: :
Yeast   484 QLSDKSEFLRKMLTISLNGTSAEISEENIGWQLVLIWCIGEYGDLVLNEGNKNGADIINESSI-T 547

  Fly   541 KYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLR-----------SADAELQQRASE 594
            .|.|   ..:.|..:|.:|.||........:...|....|:.           |.|..||.::::
Yeast   548 DYLL---TLQELYTATNLKIINYILTAALKLSVRFHDAKNIEKLRQLILSYTDSTDLSLQMKSNQ 609

  Fly   595 YLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGR-VPENEIRESKSPAPLTSAAQNNA 658
            | ::....|..|...:||.||.|.:       :.:::..|: :.:|.|  |..|..|.|
Yeast   610 Y-EIFFNQSISVKKIILETMPKFEK-------ITEEQDNGKALSKNLI--SNEPVDLLS------ 658

  Fly   659 LVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYG---------SNSN---- 710
                            ||||..:...:...:|.|...  ||:|.:::|         .|:|
Yeast   659 ----------------DLLGEDSKAESKASTGDNVKP--IDILEEIFGEKNDIAQVPKNANKEES 705

  Fly   711 -NNSSAVYNTKKFLFKNNGV--------LFENEMLQIGVK-SEFRQNLGRLGLFYGNKTQV-PLT 764
             |:||||.       .|:||        ::::..|.:... ......|..|.|::..|:.: .|.
Yeast   706 INHSSAVE-------ANSGVTLPLDANKIYDSSSLNVYASLLSANSGLAHLDLYFQAKSLISDLK 763

  Fly   765 NFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAP-TIEISFRYNG----T 824
            .|..|     ..|.||.:.......|:.|....:|.|.   |....... .:::.|..||    |
Yeast   764 TFCAV-----PKAQKLTLGQLYPSSTINASQICKQSLK---ISGSGKLKLRVKLDFHLNGSSSIT 820

  Fly   825 QQKFSIK 831
            .::|..|
Yeast   821 NEQFDHK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	136/618 (22%)
		Alpha_adaptinC2	730..839	CDD:197886	22/109 (20%)
		Alpha_adaptin_C	839..947	CDD:280460
APL4	NP_015354.1	Adaptin_N	21..617	CDD:396262	137/635 (22%)
APL4	NP_015354.1	Alpha_adaptinC2	727..828	CDD:197886	22/109 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820