DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and APL5

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_015129.1	Gene:	APL5 / 855906	SGDID:	S000006116	Length:	932	Species:	Saccharomyces cerevisiae

Alignment Length:	936	Identity:	199/936 - (21%)
Similarity:	379/936 - (40%)	Gaps:	212/936 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KRINKELANIRSKFKGDKTLDGY------------------QKKKYVCKLLFIFLLGHDIDFGHM 88
            |.:...:..|||..:..:.||.:                  .|...|.||.::.:.|.|:.:.:.
Yeast    25 KSLKDLIKGIRSHNETPEKLDQFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMYGFDMAWCNF 89

  Fly    89 EAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQ---SRNPVHVNLALQCIANIG 150
            ..:.::||||..:|::|||..|.....:||::.|....:|.||:   :.:.|.|.:||..::.|.
Yeast    90 HILEVMSSNKLQQKRVGYLAASQSFYKDSDILMLATNLLKKDLKYDGNNDVVKVGIALSGLSTII 154

  Fly   151 SRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVV 215
            :..:|...::::..:|.|  |...:::.|...|.::|...|:.:...  ..:.:..|:|..:.||
Yeast   155 TPSLARDIADDLFTMLNS--TRPYIRKKAITALFKVFLQYPEALRDN--FDKFVSKLDDDDISVV 215

  Fly   216 TAATSLIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYN 280
            :||.|:|..|.|:||..:   :.|:......:||             :...|:.::||:|..|.:
Yeast   216 SAAVSVICELSKKNPQPF---IQLSPLLYEILVT-------------IDNNWIIIRLLKLFTNLS 264

  Fly   281 PVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLL------ 339
            .|  |..:||:|             .||..::..|....:|::|::|.|:    :.|:|
Yeast   265 QV--EPKLRAKL-------------LPKILELMESTVATSVIYESVNCIV----KGNMLEEDDFE 310

  Fly   340 -VRAC-NQLGQFLSNRETNLRYLALESMCHL--ATSEFSHEEVKKHQEVVILSMKMEKDVSVRQM 400
             ..|| .:|..|..:::.||||::    |.|  ...:.:.:.:.:..:::| .:..:.|||:|..
Yeast   311 TAMACLERLHTFCDSQDPNLRYIS----CILFYKIGKINTDFISRFDQLII-RLLSDVDVSIRSK 370

  Fly   401 AVDLLYAMCDRGNAEEIVQEMLN--------YLETA----------------DYSIREEMVLKVA 441
            |::|:..:.|..|.:.|||.::.        .|:|.                :|.|:...|:...
Yeast   371 AIELVEGIVDEDNLKAIVQTLMKQFVDEDVVILQTGSIVYEKSKRIPIIIPENYKIKMVNVIISI 435

  Fly   442 ILAEKYAT--DYTWYVDVILNLIRIA--------GDYVSEEVWYRVIQIVINREEVQGYAAKTVF 496
            ..|:.|::  |:.||..||::|..:.        |..:.|:....:|::...||.......|.:.
Yeast   436 CSADNYSSVNDFEWYNAVIMDLAMLCQDISDKSLGSKIGEQFRNLMIKVPSMREVTIANIIKLIS 500

  Fly   497 E---ALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKY--HLCSPMTRALLLST 556
            .   ..|.|......:    :.||||..|:...:   .|::....:..|  |....:....|:..
Yeast   501 NDNINKQLPTVLRECI----WCLGEFSTLVENGN---DLIKIMTENISYYSHSVQEVLILALVKV 558

  Fly   557 YIKFINLFP-----EIRTNIQDVFRQHSNLR-SADAELQQRA---SEYLQLSIVA---STDVLAT 609
            :..:.|.|.     ||:..::::.....||. |:..|:|:|:   .|:|:||:.|   .|:.|..
Yeast   559 FSNWCNNFQEDKRFEIKMVLKELIEFFENLSYSSTFEVQERSVEVLEFLRLSLEALEEDTEGLPM 623

  Fly   610 VLEE-MPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNAN 673
            :|.| :|||  ..:..||.:.:....::..:|..:.::|. ||..|.:..|..      ..|:|.
Yeast   624 LLSEVLPSF--FNAYELAPIARGTQLKLAVDENLDLETPF-LTKEAADELLDE------QKSDAI 679

  Fly   674 TDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQI 738
            :||:       ::|..........:|            :|...|..|:.|..     |||. .:|
Yeast   680 SDLM-------SDISMDEQVELKFVD------------DSDTSYEEKEKLDD-----FENP-FEI 719

  Fly   739 GVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLN-----------VQMKVVEPTLE 792
            ..:.|...|...||.....:|:            :::|.|.||           :::...:.:|.
Yeast   720 EREKERMSNPYYLGEEDEERTK------------NSKDLLDLNEEESSDKKPETIRLNRTDNSLN 772

  Fly   793 AGAQIQQLLTAEC------------IEDYADAPTIEISFRYNGTQQK----FSIKLPLSVNKFFE 841
            :    ..|.|.|.            ::..:|.|.||.:.:.....||    .|.:.||..:|...
Yeast   773 S----LSLSTTEISRKKKKGKKKNRVQVLSDEPVIEAAPKRKDAFQKPHDNHSTQNPLKKDKINL 833

  Fly   842 PTEMNAESF-FARWKNLSGEQQRSQK 866
            ......|:| |:.:...|...:.||:
Yeast   834 RMHSQLENFDFSNFGQSSNAGRGSQE 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	138/634 (22%)
		Alpha_adaptinC2	730..839	CDD:197886	26/135 (19%)
		Alpha_adaptin_C	839..947	CDD:280460	6/29 (21%)
APL5	NP_015129.1	Adaptin_N	45..610	CDD:396262	133/615 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810