Protein Alignment AP-2alpha and APL3

DIOPT Version :10

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_009516.1
• Gene: APL3 / 852243
• SGDID: S000000133
• Length: 1025
• Species: Saccharomyces cerevisiae
• Alignment Length: 1036
• Identity: 266/1036 - (25%)
• Similarity: 461/1036 - (44%)
• Gaps: 191/1036 - (18%)

  Fly    35 KSKEAEVKRINKELANIRSKFKGDK-------TLDGYQKKKYVCKLLFIFLLG-----HDIDFGH 87
            :::|.| |||..|:..|:..|...|       .|.|||:||||.||.:|::..     ::|.||.
Yeast    34 QAQEQE-KRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGL 97

  Fly    88 MEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRL---IIQSIKNDLQSRNPVHVNLALQCIANI 149
            .:.|.||.|:.:|||.|||:.:.:|...:..:.::   :...:..||.|.:...|.|||..:..:
Yeast    98 EQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVMLALNFVGVV 162

  Fly   150 GSRDMAESFSNEIP----KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGG-----EWTSRIIH 205
            |......:::::|.    |:|.|..:...:|:.:||..|.|.:|:..|:...     .|..||:.
Yeast   163 GELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRILS 227

  Fly   206 LLNDQHMGVVTAAT-SLIDALVKRNPDEYKGCVNLAVSRLSRIV-------TASYTDLQ---DYT 259
            ||:|.....:|.|| .||:.:.|.....|  |..| :.:|:.|:       |:..:|.|   :||
Yeast   228 LLDDTENYRLTLATIPLIEFIAKYIDPSY--CTRL-LPQLTEILYNCVVVGTSRSSDNQFPLEYT 289

  Fly   260 YYFVPAPWLSVKLLRLLQNY--NPVTEEAGVRARLNETLETILNKAQ--------------EPPK 308
            :..:|.|||..|::.||...  :|...::|...:.|.....:|||.:              :.|.
Yeast   290 FANMPNPWLITKVVSLLSILIASPTERDSGSLLQTNNIDNELLNKLRKCVSVAIELGTRQAQDPM 354

  Fly   309 SKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATS-- 371
            .:.||     |.|||..||.....|.....:..:...|...|:::|.|:|||.|:|:..|.:|
Yeast   355 ERIVQ-----NTVLFSLINFASKLDPSDEAISNSVTALCSLLTSKEINIRYLTLDSLVKLCSSSG 414

  Fly   372 EFSHEEVK-KHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLNYL----ETADYS 431
            :.:.:.|: |:.:::...:..|:|.|:.:..|||||...|..|.:.||..:|.|:    ..|:..
Yeast   415 KPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKIIVDGLLQYILSPKNLAEPQ 479

  Fly   432 IREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYV--SEEVWYRVIQIVINREEVQGYAAKT 494
            |:.::.:|:|||.||||||..|:|.:.|.|:.:..:..  .:|:|.|:.|||:|...:.....:.
Yeast   480 IKSDIAVKIAILTEKYATDINWFVIISLQLLSLTSNTTINDDEIWQRLCQIVVNNPSLHRITCER 544

  Fly   495 VFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIK 559
            :.:.|......|.::|...::|||:.:||.....||.|  |.|...||.....:.:|::|:|.||
Yeast   545 LVDYLCKKQASEAIIKAAAFLLGEYSSLITDRISSANL--FTLFAEKYFSAPNVAKAMILTTMIK 607

  Fly   560 FINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQL----SIVASTDVLATVLEEMPSFPER 620
            .....|||.:|:...|:  ..|.|.|.|||.|:.|||.:    .:..:||:|..:.|.||.|..:
Yeast   608 LYKTSPEIGSNVIKFFQ--LELNSLDIELQTRSFEYLNIIQLAKVNGNTDILQILFEPMPPFNSK 670

  Fly   621 ESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNS---------NANTDL 676
            .:.:|     |:.|.:|              ::|.:..|: |:.|:.::|         |::..:
Yeast   671 SNPLL-----KRLGSLP--------------ASAGSTTLI-NTPSEASSSTPDLLSKRANSSRSI 715

  Fly   677 LGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTK-----------KFLFKNNGVL 730
            :....|||.        .:|:.||...:..|...:...:.|:.:           :.:....|||
Yeast   716 MVPMPPPSR--------RNTIDDVNSKISSSEDFSGKDSYYSRQILAPNWREGFTRMISHKQGVL 772

  Fly   731 FENEMLQIGVKSE---------FRQNLGRLGL----FYGNKTQV--PLTNFNPVLQWSAEDALKL 780
            |.:.::::..:..         |..:|..:.|    ..|..||:  ..|..||       :.|.:
Yeast   773 FTSSLMKVFYRITTPDAQQPYVFHISLAFINLTEWEITGLSTQIIPSKTQGNP-------EYLIM 830

  Fly   781 NVQM---------KVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLS- 835
            |:..         |..|.:.|  ..|::..      |..|:|.:.|.|:..|:....::|..:.
Yeast   831 NINTPSTATIGPHKRAEQSYE--VSIRKPF------DVEDSPILAIHFKCGGSTNTINLKTAIGM 887

  Fly   836 ----VNKFFEPT-EMNAESFFARWKNLS------GEQQRS----QKVFKAAQPLDLPGA----RN 881
                ::....|: .:|...|.:|||.||      ||.|:|    .|.|:..:.:.|...    ..
Yeast   888 TTTLISSDVNPSMHLNLAQFISRWKTLSDALGKEGEYQKSGIKLNKDFRKVETISLEDGLLLLTQ 952

  Fly   882 KLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQ-QVGCLMRLEPNKQAQMFRLTVRASKETVT 941
            .:...|..::||.... ..:..:|||||:|: ..||||:::.....     ||..:.:|.|
Yeast   953 TVKRLGFDIVDQTSVR-STLFVSGIIHTKSEGNFGCLMKIQYQVNG-----TVNVTCKTTT 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	182/626 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	24/137 (18%)
		Alpha_adaptin_C	839..947	CDD:426707	32/119 (27%)
APL3	NP_009516.1	Adaptin_N	38..649	CDD:396262	182/623 (29%)
		Alpha_adaptin_C	901..1018	CDD:426707	31/113 (27%)