DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and AT1G60070

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001185270.1	Gene:	AT1G60070 / 842301	AraportID:	AT1G60070	Length:	898	Species:	Arabidopsis thaliana

Alignment Length:	976	Identity:	248/976 - (25%)
Similarity:	442/976 - (45%)	Gaps:	182/976 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DQSRGGKESEASADESLLFYCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFL 78
            |..|..:.|:.:|:|..:            :.||.|.||:....:   |...:.:.:.||:||.:
plant    12 DMIRAIRASKTAAEERAV------------VRKECAAIRASINEN---DQDYRHRDLAKLMFIHM 61

  Fly    79 LGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLAL 143
            ||:...||.||.:.|::|..:.||:||||.:.:|::...:::.|:..|:|.||...|...|.|||
plant    62 LGYPTHFGQMECLKLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSLKQDLNHTNQYIVGLAL 126

  Fly   144 QCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPD-----IIPGGEWTSRI 203
            ..:.||.|.:||...:.|:.:||...|..  :::.||||.:|:.|..||     |.||..
plant   127 CALGNICSAEMARDLAPEVERLLQFRDPN--IRKKAALCAIRIIRKVPDLSENFINPGAA----- 184

  Fly   204 IHLLNDQHMGVVTAATSLIDALVKRNPD--EY--KGCVNLAVSRLSRIVTASYTDLQDYTYYFVP 264
              ||.::|.||:.....|...:.|.:.:  ||  |.|....|..|..|..:.|:  .:|....:.
plant   185 --LLKEKHHGVLITGVHLCTEICKVSSEALEYFRKKCTEGLVKTLRDIANSPYS--PEYDVAGIT 245

  Fly   265 APWLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLI 329
            .|:|.::||:||:...  ..:|.....:|:.|..:.:|.:        .:.||.||:|:|.:..|
plant   246 DPFLHIRLLKLLRVLG--QGDADASDCMNDILAQVASKTE--------SNKNAGNAILYECVQTI 300

  Fly   330 IHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKD 394
            :..:....|.|.|.|.||:|||||:.|:||:||..:....|.:  .:.|::|:..::..:| :.|
plant   301 MSIEENGGLRVLAINILGKFLSNRDNNIRYVALNMLMRSLTVD--SQAVQRHRATILECVK-DSD 362

  Fly   395 VSVRQMAVDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVIL 459
            .|:::.|::|:|.:.:..|.:.:.:|::.|||.::...:.::..|:..:.||:|.:..||:|.:|
plant   363 ASIQKRALELIYLLVNENNVKPLAKELIEYLEVSEQDFKGDLTAKICSIVEKFAPEKIWYIDQML 427

  Fly   460 NLIRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLI- 523
            .::..||.||.|:||:.:|.::.|..::.||..:.::.||......|.:|:|..:.:||:.:|:
plant   428 KVLSEAGTYVKEDVWHALIVVITNAPDLHGYTVRALYRALHTSFEQETLVRVAIWCIGEYADLLV 492

  Fly   524 --AG-----------DSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVF 575
              ||           :|.:..:|:..:   |:||....|:|:.|...:|..:.||.....::.:.
plant   493 NNAGMLDLEDPITVTESDAVDVVENAI---KHHLSDVTTKAMALIALLKISSRFPSCSERVKSII 554

  Fly   576 RQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENE 640
            .|  |..|...|||||:.|:..: |....::.::::|.||...|      |....::.|.:|.:.
plant   555 GQ--NKGSFVLELQQRSLEFSSV-IQKHQNIRSSLVERMPVLDE------ATFSGRRAGSLPASV 610

  Fly   641 IRESKSPAPLTSAAQNNA--LVNNSHSKLNNSNANTDLLGL---STPPSNNIGSGSNSNSTLIDV 700
            ....|||..:.:.....|  ||              |||.|   .||...     |:||:.|.|:
plant   611 STSGKSPLGIPNGVAKAAAPLV--------------DLLDLGSDDTPAPT-----SSSNNFLQDL 656

  Fly   701 LG-DMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLT 764
            || |:  |..:....|:..::.      |.....::|.||..:
plant   657 LGVDL--SQPSAQPGAMQPSQA------GADILMDLLSIGTPA---------------------- 691

  Fly   765 NFNPVLQWSAE-DALKLNVQMKVVEPTL---EAGAQIQQLL-----TAECIEDYADA-PTIEISF 819
               ||...||. |.|.:......:.|:|   .|.:.:..||     |....||.:.| |:| ::|
plant   692 ---PVQNGSANGDLLSIQDNNAPIAPSLTSPTAPSSMMDLLDGFGPTPPKSEDKSAAYPSI-VAF 752

  Fly   820 RYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQP---------LD 875
                  :..|:|:..:..|..|..:  .....|.:.||: ....::.:|:||.|         |:
plant   753 ------ESSSLKIEFNFTKQSENPQ--TTDIVANFINLT-PNVYTEFLFQAAVPKNNSAMCLVLN 808

  Fly   876 LP----GARNKLMGFGMQLLDQV---------DPNPDNMVCAG--------IIHTQSQQVGCLMR 919
            :|    ...::.|.|...||.::         ||...|.:.|.        :.::|..:...:||
plant   809 VPHFYGRDSDRFMFFAKFLLVEILGTFLQLHLDPASSNSLPANGNIKQTMRVTNSQKGKKPIVMR 873

  Fly   920 L 920
            :
plant   874 M 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	167/580 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	23/118 (19%)
		Alpha_adaptin_C	839..947	CDD:280460	21/112 (19%)
AT1G60070	NP_001185270.1	Adaptin_N	26..580	CDD:279882	169/598 (28%)
AT1G60070	NP_001185270.1	Alpha_adaptinC2	751..895	CDD:197886	25/133 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820