DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-2alpha and GAMMA-ADAPTIN 1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_173802.1	Gene:	GAMMA-ADAPTIN 1 / 839001	AraportID:	AT1G23900	Length:	876	Species:	Arabidopsis thaliana

Alignment Length:	939	Identity:	239/939 - (25%)
Similarity:	436/939 - (46%)	Gaps:	143/939 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98
            ||:...|...:.||.|:||:....|   |.:.:.:.:.||:||.:||:...||.||.:.|::|..
plant    20 CKTAAEERAVVRKECADIRALINED---DPHDRHRNLAKLMFIHMLGYPTHFGQMECLKLIASPG 81

  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163
            :.||:||||.:.:|::...:::.|:..|:|.||...|...|.|||..:.||.|.:||...:.|:.
plant    82 FPEKRIGYLGLMLLLDERQEVLMLVTNSLKQDLNHSNQYVVGLALCALGNICSAEMARDLAPEVE 146

  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228
            :|:...|..  :::.||||..|:.|..||:  ...:.:....||.::|.||:.....|...|...
plant   147 RLIQFRDPN--IRKKAALCSTRIIRKVPDL--AENFVNAAASLLKEKHHGVLITGVQLCYELCTI 207

  Fly   229 NPD--EY--KGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVR 289
            |.:  ||  ..|....:..|..|..::|.  .:|....:..|:|.::|||||:.......:|
plant   208 NDEALEYFRTKCTEGLIKTLRDITNSAYQ--PEYDVAGITDPFLHIRLLRLLRVLGQGDADA--- 267

  Fly   290 ARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRE 354
               ::.:..||.:.....:|.|    ||.||||:|.:..|:..:...:|.|.|.|.||:|||||:
plant   268 ---SDLMTDILAQVATKTESNK----NAGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRD 325

  Fly   355 TNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQ 419
            .|:||:||..:....|  |..:.|::|: |.||....:.|.|:|:.|::|:..:.:..|..::.:
plant   326 NNIRYVALNMLMKAIT--FDDQAVQRHR-VTILECVKDPDASIRKRALELVTLLVNENNVTQLTK 387

  Fly   420 EMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINR 484
            |:::|||.:|...:|::..|:..:.||::.:..||:|.:|.::..||.:|.::||:.:|.::.|.
plant   388 ELIDYLEISDEDFKEDLSAKICFIVEKFSPEKLWYIDQMLKVLCEAGKFVKDDVWHALIVVISNA 452

  Fly   485 EEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAG--------------DSRSAPLVQF 535
            .|:.||..:.:::::...:..|.:|:|..:.:||:|:|:..              :|.:..:::.
plant   453 SELHGYTVRALYKSVLTYSEQETLVRVAVWCIGEYGDLLVNNVGMLGIEDPITVTESDAVDVIED 517

  Fly   536 KLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVF-RQHSNLRSADAELQQRASEYLQLS 599
            .:..   |.....|:|:.|...:|..:.||.|...|:|:. :|..:|.   .|:||||.||..:
plant   518 AITR---HNSDSTTKAMALVALLKLSSRFPSISERIKDIIVKQKGSLL---LEMQQRAIEYNSI- 575

  Fly   600 IVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSH 664
            :....::.:::::.||...|...::.                |....||.:::.|:.:..:.|..
plant   576 VDRHKNIRSSLVDRMPVLDEATFNVR----------------RAGSFPASVSTMAKPSVSLQNGV 624

  Fly   665 SKLNNSNANTDLLGLSTPPSNNIGSGSNSNST--LIDVLGDMYGSNSNNNSSAVYNTKKFLFKNN 727
            .||..:.. .|||.|.   |::|.:..:.:.|  |.|:||...||     |||.|...:......
plant   625 EKLPVAPL-VDLLDLD---SDDIMAAPSPSGTDFLQDLLGVDLGS-----SSAQYGATQAPKAGT 680

  Fly   728 GVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLE 792
            .:|.  ::|.||..|..:.:...:||.     .:...|.||                .:...||.
plant   681 DLLL--DILSIGTPSPAQNSTSSIGLL-----SIADVNNNP----------------SIALDTLS 722

  Fly   793 AGAQIQQLLTA-----ECIEDYADAPTIEISFRYNG-------TQQKFSIKLPLSVNKFFEPTEM 845
            :.|......|:     :.::..:.:|:.|.:   ||       ..:..|:|:..:.:|  .|..:
plant   723 SPAPPHVATTSSTGMFDLLDGLSPSPSKEAT---NGPAYAPIVAYESSSLKIEFTFSK--TPGNL 782

  Fly   846 NAESFFARWKNLSGEQQRSQKVFKAAQP------LDLPGARNKLMGFGMQLLDQVDPNPDNMVCA 904
            ...:..|.:.||| ....:..:|:||.|      || |.:.|.|:..|...:.|
plant   783 QTTNVQATFTNLS-PNTFTDFIFQAAVPKFLQLHLD-PASSNTLLASGSGAITQ----------- 834

  Fly   905 GIIHTQSQQVGCLMRLEPNKQAQMFRLTV 933
            .:..|.|||         .|::.:.|:.:
plant   835 NLRVTNSQQ---------GKKSLVMRMRI 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	167/576 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	20/120 (17%)
		Alpha_adaptin_C	839..947	CDD:280460	22/101 (22%)
GAMMA-ADAPTIN 1	NP_173802.1	Adaptin_N	26..580	CDD:279882	167/582 (29%)
		HEAT repeat	314..338	CDD:293787	13/23 (57%)
		Cnd1	317..450	CDD:289487	44/135 (33%)
		HEAT repeat	350..378	CDD:293787	9/28 (32%)
		HEAT repeat	388..417	CDD:293787	9/28 (32%)
		HEAT repeat	425..447	CDD:293787	6/21 (29%)
		AP3B1_C	718..>801	CDD:291462	16/88 (18%)
		Alpha_adaptinC2	763..873	CDD:197886	25/116 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820