DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and alpha-ADR

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001330969.1	Gene:	alpha-ADR / 832340	AraportID:	AT5G22770	Length:	1012	Species:	Arabidopsis thaliana

Alignment Length:	985	Identity:	379/985 - (38%)
Similarity:	567/985 - (57%)	Gaps:	98/985 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98
            |::||||..|::|||.|||:.||.:|.|..|:|||||.|:|:|.:||:|:||||||||:|:|:.|
plant    17 CQNKEAERLRVDKELGNIRTCFKNEKVLTPYKKKKYVWKMLYIHMLGYDVDFGHMEAVSLISAPK 81

  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163
            |.|||:||:..|.|:|.|.|.::|.|.:::||:..||.....|||..:.|||.||.|||.:.::.
plant    82 YPEKQVGYIVTSCLLNENHDFLKLAINTVRNDIIGRNETFQCLALTLVGNIGGRDFAESLAPDVQ 146

  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228
            |||:|.....:|::.||||||||||.:||.:....|..|:..||:::.:||:|::|||:.|||..
plant   147 KLLISSSCRPLVRKKAALCLLRLFRKNPDAVNVDGWADRMAQLLDERDLGVLTSSTSLLVALVSN 211

  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDL-QDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARL 292
            |.:.|..|:...|..|.|:  |...|: |:||||.:|:|||.||.:|.|| |.|..|:...|..|
plant   212 NHEAYSSCLPKCVKILERL--ARNQDVPQEYTYYGIPSPWLQVKAMRALQ-YFPTIEDPSTRKAL 273

  Fly   293 NETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNL 357
            .|.|:.||   ......|.|..:||.:||||||::|::|.|:|..::.:....||:|:|.||.|:
plant   274 FEVLQRIL---MGTDVVKNVNKNNASHAVLFEALSLVMHLDAEKEMMSQCVALLGKFISVREPNI 335

  Fly   358 RYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEML 422
            |||.||:|..:.......:.:||||..:|.|:| :.|:|:|:.|:||||.|||..||::||:|:|
plant   336 RYLGLENMTRMLMVTDVQDIIKKHQSQIITSLK-DPDISIRRRALDLLYGMCDVSNAKDIVEELL 399

  Fly   423 NYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEV 487
            .||.||::|:|||:.||.||||||:|.|.:|||||||.||..|||:||:::|:||:|.|.|.|::
plant   400 QYLSTAEFSMREELSLKAAILAEKFAPDLSWYVDVILQLIDKAGDFVSDDIWFRVVQFVTNNEDL 464

  Fly   488 QGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRAL 552
            |.|||....|.|...|.||.||||..|||||:|:|:|.....:....|.:||.|....|..|..:
plant   465 QPYAASKAREYLDKIAIHETMVKVSAYILGEYGHLLARQPGCSASELFSILHEKLPTISTPTIPI 529

  Fly   553 LLSTYIKFINLF----PEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSI--VASTDVLATVL 611
            |||||.|.:...    ||::..:..||:::.:  ..|.|:||||.||.:||.  .|..||||
plant   530 LLSTYAKLLMHAQPPDPELQKKVWAVFKKYES--CIDVEIQQRAVEYFELSKKGPAFMDVLA--- 589

  Fly   612 EEMPSFPERESSILAVLKKKKPGRVPEN------EIRESKSPAPLTSAAQNNALVNNSHSKLNNS 670
             |||.||||:||::     ||...|.:.      ::|..:.|        :||:|......:|.:
plant   590 -EMPKFPERQSSLI-----KKAENVEDTADQSAIKLRAQQQP--------SNAMVLADQQPVNGA 640

  Fly   671 --NANTDLLGLSTPPSNNIGSGSNSNSTLI---------DVLGDMYG-----------SNSNN-- 711
              .....:|..||.|.:...|.|:.|.||.         |:|.|:.|           ||..:
plant   641 PPPLKVPILSGSTDPESVARSLSHPNGTLSNIDPQTPSPDLLSDLLGPLAIEAPPGAVSNEQHGP 705

  Fly   712 ----------NSSAVY------NTKKFL-----------FKNNGVLFENEMLQIGVKSEFRQNLG 749
                      :.||:.      ||.:.:           .|::|||:|:..:|||:|:|:|.:.|
plant   706 VGAEGVPDEVDGSAIVPVEEQTNTVELIGNIAERFHALCLKDSGVLYEDPHIQIGIKAEWRGHHG 770

  Fly   750 RLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPT 814
            ||.||.|||...|||:...::...|.    |.:.:..|..|:...||:|..|....|....|...
plant   771 RLVLFMGNKNTSPLTSVQALILPPAH----LRLDLSPVPDTIPPRAQVQSPLEVMNIRPSRDVAV 831

  Fly   815 IEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGA 879
            ::.|:::........:::|.::|||.:|.::.:|.||.:|:.:||...:.|:|.:..:||.||..
plant   832 LDFSYKFGANVVSAKLRIPATLNKFLQPLQLTSEEFFPQWRAISGPPLKLQEVVRGVRPLALPEM 896

  Fly   880 RNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQ-QVGCLMRLE--PNKQAQMFRLTVRASKETVT 941
            .|....|.:.:...:||||:|:|.:...:::|. .:.||.|:|  |..:.|: |:||.....|:|
plant   897 ANLFNSFHVTICPGLDPNPNNLVASTTFYSESTGAILCLARIETDPADRTQL-RMTVGTGDPTLT 960

  Fly   942 REICDLLTDQ 951
            .|:.:.:.:|
plant   961 FELKEFIKEQ 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	259/562 (46%)
		Alpha_adaptinC2	730..839	CDD:197886	32/108 (30%)
		Alpha_adaptin_C	839..947	CDD:280460	35/110 (32%)
alpha-ADR	NP_001330969.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	486	1.000	Domainoid score	I83
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5335
Inparanoid	1	1.050	646	1.000	Inparanoid score	I177
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		otm3231
orthoMCL	1	0.900	-	-		OOG6_101447
Panther	1	1.100	-	-	LDO	PTHR22780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840