Protein Alignment AP-2alpha and ap4e1

DIOPT Version :9

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: XP_699042.2
• Gene: ap4e1 / 570467
• ZFINID: ZDB-GENE-061221-3
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1059
• Identity: 229/1059 - (21%)
• Similarity: 429/1059 - (40%)
• Gaps: 270/1059 - (25%)

  Fly    36 SKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYS 100
            ||..|...|.:||:.::.:.....| ...|.::.:.:.::..:||:|..|.::.|:.|.......
Zfish    41 SKHDEESLIKQELSAMKEQVSAPST-SMKQMREIMVRSMYCEMLGYDASFSYIHAIKLAQQGGVM 104

  Fly   101 EKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKL 165
            ||::|||.:|:.::...:|:.|::.::..||||.|.:...:||..:|.:..:||       ||.:
Zfish   105 EKRVGYLAVSLFLSEGHELLLLLVNTVLKDLQSTNLIEACMALTVVAQVFPKDM-------IPAV 162

  Fly   166 L-VSGDTM----DVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIH-----LLNDQHMGVVTAATS 220
            | :..|.:    :::::.|.|.|.:.:..:|:.:       :.||     .|.|:..||:|::..
Zfish   163 LPLVEDKLSHPKEIIRRKAVLALYKFYLIAPNQV-------QHIHAKFRKALCDKDPGVMTSSLH 220

  Fly   221 LIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEE 285
            :...|::.:||.||......|:.|.::|.....  .|:.|:.||||||.::|||:|....  .::
Zfish   221 IYLQLIQESPDAYKDLTGSFVTILKQVVGGKLP--LDFNYHSVPAPWLQIQLLRILSLLG--RDD 281

  Fly   286 AGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLI--IHSDSEPNLLVRACNQLGQ 348
            ......:.|.|:..|.:|:        .:.|...|:|||.:..:  ||..:|  ||.:|...:|.
Zfish   282 QSTSELMYEVLDESLRRAE--------MNHNITYAILFECVKAVYTIHPKAE--LLEKAARCIGN 336

  Fly   349 FLSNRETNLRYLALESMCHLATSEFSHEE--VKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDR 411
            |:.:.:.||:||.|:::.::.    .|:.  ..:||..:|..:. ..|.::::..::||:.:.:.
Zfish   337 FVLSPKINLKYLGLKALTYVV----QHDAKLALQHQMTIIECLD-HSDFTIKRETLELLFRITNA 396

  Fly   412 GNAEEIVQEMLNYLET-ADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWY 475
            .|...||::||::|.: :|......:..|||.||||:|.|.:|::..:.::..|.||.:.:::..
Zfish   397 QNVSVIVEKMLDFLRSCSDEHTIIHLAGKVAELAEKFAPDNSWFIQTMNDVFSIGGDLLQQDISN 461

  Fly   476 RVIQIVI----NREE---VQGYAAKTVFEALQAPACH--ENMVKVGGYILGEFGNL-IAGDSRSA 530
            ..::::.    ::||   ::.||..:....|...|.|  :..::|..:::||:.:| ...|....
Zfish   462 NFLRLLAEGSESKEEDDQLRLYAVDSYLTLLNGDASHLPQRFIQVMSWVVGEYSHLQECVDQSEV 526

  Fly   531 PLVQFKLLHSKYHLCSPMTRALLLSTYIK--------FINLFPEIRTNIQDVFRQHSN-LR--SA 584
            ..:..|||..|  ..|..||..:||...|        .:.|...|.::...:.||.:: ||  |.
Zfish   527 IRLLMKLLEQK--SVSSETRVWILSALTKISDGQTDLILELAESISSSQDTILRQQAHELRHLSL 589

  Fly   585 DAELQQ----RASEYLQLSIVASTDVLATVLEE-------------------------------- 613
            |::|.:    |.:.:..:.:.:|...|...:.|
Zfish   590 DSKLHEWVLPRGAAWDDMEVDSSLSFLDGFVSEALAAGAAPYKPPHQRQEELCEQRALNLEPYSF 654

  Fly   614 -MP------SFPERES-SILAV----------LKKK----------------KPGRVPENEIRES 644
             :|      |..:|.| ::|:|          |.:|                |.|.:|:.|...:
Zfish   655 SLPVSLSSCSITDRHSPTLLSVSSGLSGNSTELSQKAGASTLILEGVKRVWGKDGYLPQKETAVT 719

  Fly   645 KSPAPLTSAA-----QNNA-----------LVNNSHSKLNNS-------NANTDLLGLSTPP--- 683
            .||....|||     |..|           ...|...:|.:|       .::|.|||.|..|
Zfish   720 ASPVDEPSAAVQPVGQQEAAERLEPQPEPSTQTNDKQQLASSLFVGLSTQSSTSLLGKSEAPPPR 784

  Fly   684 --------SNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYN-TKKFLFKNNGVLFENEMLQI- 738
                    .:::.|.|:|.:           |..:::|...:| |..||:   |.|.|.|....
Zfish   785 FRKKPRPHGSSLSSSSSSGT-----------SEKSSSSRTSHNTTDSFLY---GSLLEEEPAGFD 835

  Fly   739 ---------------GVKSEFRQNLGR-LG----------LFYGNKTQVPLTNFNP--------- 768
                           .||.:.|.|..: ||          :.:...|...||...|
Zfish   836 HTPKSITANGLGQNKDVKEDRRTNTSQILGSDMVIVRPNTIQHNPSTSSDLTTLLPADLKDLPHS 900

  Fly   769 -VLQWSAEDALKLN---------------VQMKVVEPTLEAGAQI--QQLLT-------AECIE- 807
             |:..:::.:|.::               :.........:...|:  .||.|       .:|:|
Zfish   901 DVISLTSDPSLSVSSCRVFRDEALLLVIFISNSTETDIRDVAVQLNCDQLETVSLRGNIVDCLEG 965

  Fly   808 ------DYA---DAPTIEISFRYN-------GTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKN 856
                  .||   |.|...:||..:       |.....|....||...|..|..:..:.:...|.:
Zfish   966 RSVSVCHYALLMDDPHTNVSFTGSVSYQIQPGHTNTLSFSGTLSTADFIRPLVVTTDEYGKLWLS 1030

  Fly   857 LSGEQQRSQKVF-KAAQPL 874
            ||.:.:::.|:. .|..||
Zfish  1031 LSHDVKQNLKLLTDAGDPL 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	146/597 (24%)
		Alpha_adaptinC2	730..839	CDD:197886	31/186 (17%)
		Alpha_adaptin_C	839..947	CDD:280460	9/37 (24%)
ap4e1	XP_699042.2	Adaptin_N	45..592	CDD:279882	144/582 (25%)
		AP4E_app_platf	1016..1116	CDD:291473	8/34 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910