DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and ap3d1

DIOPT Version :9

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:XP_009294538.1 Gene:ap3d1 / 563359 ZFINID:ZDB-GENE-050208-437 Length:1270 Species:Danio rerio


Alignment Length:690 Identity:157/690 - (22%)
Similarity:294/690 - (42%) Gaps:179/690 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|:..:..|:.:.|.|...   .|...||||.::.:||:|:.:.....|.::||:|::.
Zfish    29 KEDEAKYISTCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDVSWAAFNIVEVMSSSKFTY 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |:||||..|...:..:|:|.|....|:.||.|.|.....:||..::...:.|:|...:|:|..|:
Zfish    91 KRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
Zfish   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
Zfish   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
Zfish   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETN--------LRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMC 409
            .:.|        ::||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|.
Zfish   315 SDQNCEPSVNACMKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMV 376

  Fly   410 DRGNAEEIVQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYV 469
            .:.|..|||::::.:::.|: .:.|:|::.|:..:..    :|.|::.||:.:::.|.|:.|...
Zfish   377 SKKNLMEIVKKLMLHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRH 441

  Fly   470 SEEVWYRVIQIVINREEVQGYAA-------------------KTVFEALQAPACHENMVKVGGYI 515
            ...:..:::.:.|..:.::.:|.                   ..:.|.|.|.|          :|
Zfish   442 GHLIASQMLDVAIRVKAIRAFAVAQMATLLDNAHLLTGNTQRNGICEVLYAAA----------WI 496

  Fly   516 LGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRT---NIQDVFRQ 577
            .|||..                     ||..||   |.|...::     |::.|   :||.|:.|
Zfish   497 CGEFAE---------------------HLEDPM---LTLEAMLR-----PKVATLPGHIQAVYVQ 532

  Fly   578 HSN---------------------------------LRSADAELQQRASEYLQL----------S 599
            ::.                                 ::||:.|:|:|||..|||          :
Zfish   533 NAAKLFATVLQKHEGETDSQAAQETSQLLIDRLPLFVQSANLEVQERASCILQLVKYIQKLQQKN 597

  Fly   600 IVASTDVLATVLEEM-PSFPERESSILAVLKKKKPGRVPE 638
            :..:.:|.|....|: |..|:.:        ||.|  :||
Zfish   598 VEVAEEVTALFAGELNPVAPKAQ--------KKVP--IPE 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..598 CDD:279882 143/634 (23%)
Alpha_adaptinC2 730..839 CDD:197886
Alpha_adaptin_C 839..947 CDD:280460
ap3d1XP_009294538.1 Adaptin_N 32..588 CDD:279882 145/636 (23%)
HEAT repeat 151..172 CDD:293787 5/22 (23%)
Cnd1 155..265 CDD:289487 30/132 (23%)
HEAT repeat 185..209 CDD:293787 8/23 (35%)
HEAT repeat 221..250 CDD:293787 6/44 (14%)
HEAT repeat 258..293 CDD:293787 10/47 (21%)
HEAT repeat 302..332 CDD:293787 6/29 (21%)
HEAT repeat 343..372 CDD:293787 8/29 (28%)
BLVR 669..813 CDD:283923
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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