DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and g

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	205/921 - (22%)
Similarity:	381/921 - (41%)	Gaps:	199/921 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYS 100
            :|:.|.|.|:..:..|:.:.:.|..   ..|...|.||.:|.:||:||.:.....:.::||::::
  Fly    29 NKDNEAKYISTCIEEIKQELRQDNI---SVKCNAVAKLTYIQMLGYDISWAGFNIIEVMSSSRFT 90

  Fly   101 EKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKL 165
            .|:||||..|...:.:|:|:.|....|:.||.|:|.....:||..::...|.|::...:|:|..|
  Fly    91 CKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPDLSRDLANDIMTL 155

  Fly   166 LVSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRN 229
            :.|  |...::..|.|.:.::|...|:.: |.   ..::...|.|...||.:||.::|..|.::|
  Fly   156 MSS--TKPYLRMKAVLMMYKVFLRYPEALRPA---FPKLKEKLEDPDPGVQSAAVNVICELARKN 215

  Fly   230 PDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNE 294
            |..|.....:    ..:::|.|..:            |:.:|:::|.....|:....|  .:|.|
  Fly   216 PKNYLPLAPI----FFKLMTTSTNN------------WMLIKIIKLFGALTPLEPRLG--KKLIE 262

  Fly   295 TLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLS 351
            .|..::             ||.:..::|:|.||.:|.     |...||  ..::.|.| |...:.
  Fly   263 PLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIE 314

  Fly   352 NRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEE 416
            :.:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..|
  Fly   315 DSDQNLKYLGLLAMSKILKTH--PKSVQAHKDLILACLD-DKDESIRLRALDLLYGMVSKKNLME 376

  Fly   417 IVQEMLNYLETADYS-IREEMVLKV-AILAEK---YATDYTWYVDVILNLIRI-AGDYVSEEVWY 475
            ||:.:|.::|.|:.| .|:|::.|| .|.|:.   |.|::.||:.|::.||:: ||......:..
  Fly   377 IVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAE 441

  Fly   476 RVIQIVINREEVQGYAAKTVFEAL-------QAPACHENMVKVGGYILGEFGNLIAGDSRSAPLV 533
            :::.:.|....|:.:|...:...|       |:.:.:| ::....:|:|||    ||:...|.
  Fly   442 QLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYE-VLYAAAWIVGEF----AGELEDAE-- 499

  Fly   534 QFKLLHSKYHLCSPMTRALLLSTYIK------FINLFPEIRT---NIQDV------------FRQ 577
              |.|:.       :.|..||..:|:      .|.||..:.|   .:||:            ..|
  Fly   500 --KTLNI-------LLRPRLLPGHIQGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQ 555

  Fly   578 HSNLRSADAELQQRAS------EYLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGR- 635
            |.| .|:|.|:|:||:      |.|:..:..|||.:|.........|.....|:..:.....|.
  Fly   556 HFN-GSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGEL 619

  Fly   636 VPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGL----STPPSNNIGSGSNSNST 696
            :|.....:.|.|.|                         |.|.|    :.||..:..|.|:|...
  Fly   620 IPVAPKAQRKVPLP-------------------------DGLDLDEWINAPPPEDAASSSSSEHD 659

  Fly   697 LIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQV 761
                ..:::.|.:...:.|....|:           .:.|::..:...||.:.||         :
  Fly   660 ----KDELFVSATQAGTGADGGEKR-----------RQSLELTPEQLERQRMARL---------I 700

  Fly   762 PLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQ 826
            ..:| ||....|...|               :||.     .|:..::..|.|..|:.....|. .
  Fly   701 EQSN-NPHYLKSTPTA---------------SGAS-----NADQYDNIDDIPITELPLDMEGV-A 743

  Fly   827 KFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLL 891
            ...:.:....:|:.:..:....|...:.|:..|::.:.              |:|| :.:.....
  Fly   744 ALRVGITKRSDKYLQEQQAAQGSKDGKKKHKKGKKSKK--------------AKNK-VAYNSSSE 793

  Fly   892 DQVDPNPDNMV 902
            .:.:|.|.::|
  Fly   794 SEGEPKPLHIV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	155/606 (26%)
		Alpha_adaptinC2	730..839	CDD:197886	17/108 (16%)
		Alpha_adaptin_C	839..947	CDD:280460	9/64 (14%)
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	153/603 (25%)
		HEAT repeat	152..173	CDD:293787	6/22 (27%)
		HEAT repeat	185..213	CDD:293787	8/30 (27%)
		Cnd1	<193..266	CDD:289487	21/90 (23%)
		HEAT repeat	221..263	CDD:293787	8/59 (14%)
		HEAT repeat	272..290	CDD:293787	5/17 (29%)
		HEAT repeat	302..331	CDD:293787	9/28 (32%)
		BLVR	687..840	CDD:283923	26/164 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810